Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis

Frontiers in Immunology, Год журнала: 2025, Номер 15

Опубликована: Янв. 7, 2025

This study aimed to investigate whether tumor-associated lymphatic vessel density (LVD) could predict the survival of patients with hepato-biliary-pancreatic (HBP) cancers after radical resection. A systematic search was conducted using PubMed, Embase, and Cochrane Library from inception July 31, 2024 for literature that reported role LVD in overall (OS) recurrence-free (RFS) HBP Ten studies 761 were included meta-analysis. The results indicated a higher level associated worse OS (hazard ratio, HR = 2.87, 95% CI 1.63 5.04) RFS (HR 3.18, 1.41 7.17) cancers. Subgroup analysis based on pathological types revealed significantly related hepatocellular carcinoma (HCC) 2.35, 1.16 4.78), cholangiocarcinoma 4.65, 1.70 12.70), gallbladder cancer 4.64, 1.37 15.71). levels not pancreatic adenocarcinoma resection 1.08, 0.61 1.89). Similarly, HCC 1.92, 1.01 3.65) 4.54, 2.10 9.83). biomarker prediction hepatobiliary https://www.crd.york.ac.uk/prospero/, identifier CRD42024571167.

Язык: Английский

---

The effectiveness and safety of therapies for hepatocellular carcinoma with tumor thrombus in the hepatic vein, inferior vena cave and/or right atrium: a systematic review and single-arm meta-analysis

Expert Review of Anticancer Therapy, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

This review evaluates the efficacy and safety of therapies for hepatocellular carcinoma (HCC) with hepatic vein tumor thrombus (HVTT), inferior vena cava (IVCTT), and/or right atrium (RATT). A systematic PubMed, EMBASE, Cochrane Library, Wanfang databases was conducted literatures in this topic up to 22 August 2024, focusing on overall survival (OS), progression -free (PFS), adverse reactions. Seven studies involving 453 patients were analyzed. The therapeutic strategies included surgery alone, local ± systemic therapy, adjuvant therapy. pooled 1-, 3-, 5-year OS rates all 63.3% (95% CI 52.7%-73.9%), 21.6% 4.9%-38.2%), 8.3% 2.9%-13.8%), respectively. Surgery therapy achieved highest 1-year OS, while led best OS. PFS 56.8% 45.2%-68.4%), 9.4% 0.0%-20.0%), 1.6% 0.0%-3.8%), alone frequently had reactions ascites pleural effusion, resulted dysfunction platelet abnormalities, accompanied by peritoneal abscess. Local provided long-term manageable complications among these three HCC HVTT, IVCTT, RATT. PROSPERO, (CRD42024573152).

Язык: Английский

---

The role of histone lactylation genes in hepatocellular carcinoma prognostic models and their immune cell infiltration features: a comprehensive analysis of single-cell, spatial transcriptome, Mendelian randomization and experiment

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 10, 2025

With the increasing impact of hepatocellular carcinoma (HCC) on society, there is an urgent need to propose new HCC diagnostic biomarkers and identification models. Histone lysine lactylation (Kla) affects prognosis cancer patients emerging target in treatment. However, potential Kla-related genes poorly understood. A variety machine learning methods were used construct validate a model differentially expressed Kla with comprehensive evaluations included ROC, Kaplan‒Meier curve, Cox regression, decision curve. Immune infiltration gathered spatial transcriptome was performed using integrated data from multiple databases. Furthermore, single-cell analysis discover cell–cell communication Mendelian randomization study causal relationships between immune cell HCC. Lastly, qRT-PCR verify expression genes. We established consisting 12 that had well prognostic performance identified as independent factors. Single-cell showed CD8 T+ cells conventional dendritic enriched patients. Spatial transcriptomics indicated influenced characteristics results TBNK monocytes main risk validation Huh7 significantly higher than LO2 cells. Overall, established, which may provide strategies insights for treatment diagnosis

Язык: Английский

---

Impact of frailty on the long-term prognosis of the elderly with hepatocellular carcinoma treated with transarterial chemoembolization

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 13, 2025

Transcatheter arterial chemoembolization (TACE) is a standard treatment for unresectable, intermediate, or advanced-stage hepatocellular carcinoma (HCC), especially in elderly patients. The modified 5-item frailty index (mFI-5) concise, comorbidity-based risk stratification tool proven to effectively predict adverse outcomes. However, the prognostic capacity of mFI-5 HCC patients after TACE unclear. As such, we retrospectively analyzed clinical data from (age ≥ 65 years) who received their first between November 2018 and 2020 at Department Interventional Radiology, Affiliated Hospital Xuzhou Medical University. was calculated based on presence five co-morbidities: congestive heart failure within 30 days prior surgery; insulin-dependent noninsulin-dependent diabetes mellitus; chronic obstructive pulmonary disease (COPD) pneumonia; partially dependent totally functional health status time hypertension requiring medication. Patients were divided into two groups scores: 2 ('frail') < ('non-frail'). primary outcomes overall survival (OS) progression-free (PFS).Among 143 patients, 97 group 46 group. median OS 40.0 months (95% confidence interval [CI]: 35.0-47.0) non-frail vs. 24.0 CI: 22-NA) frail (hazard ratio [HR] = 3.343, 95% 1.802-6.201, p .001). PFS 7.0 4.0-11.0) 3.0 2.0-9.0) (HR 1.507, 0.996-2.280, .053). Cox regression identified mFI-5, alpha-fetoprotein (AFP) as independent predictors OS. useful predictor long-term treated with TACE, suggesting that incorporating assessments can optimize strategies improve

Язык: Английский

---

Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 16, 2025

Язык: Английский

---

Mechanistic link between long noncoding RNA and stability of oncogene reveals stemness and chemoresistance of hepatocellular carcinoma

World Journal of Gastroenterology, Год журнала: 2025, Номер 31(7)

Опубликована: Янв. 18, 2025

This letter comments on the recently published manuscript by Yu et al, in which authors revealed a novel mechanism m6A-modified long noncoding RNA kinesin family member 9-antisense 1 promotes stemness and sorafenib resistance of hepatocellular carcinoma (HCC) through ubiquitin-specific peptidase 1-mediated deubiquitination oncogene short stature homeobox 2. Given high mortality rate poor prognosis HCC, findings al open new avenue for overcoming HCC burden focusing 2 as prognostic markers therapeutic targets.

Язык: Английский

---

Outcomes and Prognostic Factors in Cirrhotic Patients with Acute Variceal Bleeding and Hepatocellular Carcinoma: A Nested Case–Control Study

Journal of Hepatocellular Carcinoma, Год журнала: 2025, Номер Volume 12, С. 343 - 352

Опубликована: Фев. 1, 2025

The treatment outcomes and risk factors for the prognosis of acute variceal bleeding (AVB) in hepatocellular carcinoma (HCC) patients remain unclear. Hence, we assessed clinical prognostic these patients. This study retrospectively enrolled 1532 AVB with cirrhosis from January 2016 to December 2022. Of patients, 310 had HCC, after 1:1 individual matching, 306 them were matched without HCC. Six-week mortality, one-year five-day failure recorded. In matched-pair analysis, HCC a higher rate 6-week 1-year mortality than those (6-week: 24.5% vs 7.8%, P < 0.001; 1-year: 45.9% 16.2%, 0.001). 5-day was similar between two groups (21.1% 16.7%, = 0.213). Among multivariate analysis revealed that Child-Pugh score (HR, 1.239, 95% CI, 1.121-1.370; 0.001) Barcelona Clinic Liver Cancer (BCLC) stage (C-D 0-B) 14.409; 5.758-36.055; independently associated mortality. Moreover, 60.2% who high (≥9) advanced BCLC (C-D), much low (<9) earlier (0-B) (P AVB, significantly worse without. severity liver disease are main determinants

Язык: Английский

---

Adverse events associated with hepatic arterial infusion chemotherapy and its combination therapies in hepatocellular carcinoma: a systematic review

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 3, 2025

Background Hepatic arterial infusion chemotherapy (HAIC) has emerged as a promising treatment for unresectable hepatocellular carcinoma (HCC). However, the safety profiles of HAIC and its various combination therapies remain to be systematically evaluated. Methods We searched PubMed, Embase, Cochrane Library, Web Science databases from inception November 2024. Studies reporting adverse events (AEs) monotherapy or in HCC were included. The severity frequency AEs analyzed according different protocols. Results A total 58 studies (11 prospective, 47 retrospective) demonstrated relatively mild toxicity, primarily affecting hepatobiliary (transaminase elevation 53.2%, hypoalbuminemia 57.2%) hematological systems (anemia 43.0%, thrombocytopenia 35.2%). with targeted therapy showed increased events, including characteristic reactions like hand-foot syndrome (48.0%) hypertension (49.9%). combined targeted, immunotherapy exhibited highest reaction rates (neutropenia 82.9%, transaminase 97.1%), while anti-angiogenic favorable profile. Prospective consistently reported higher incidence than retrospective studies, suggesting potential underreporting clinical practice. Conclusions Different HAIC-based regimens exhibit distinct requiring individualized management approaches. propose comprehensive framework patient selection, monitoring strategies, AE management. These recommendations aim optimize outcomes minimizing impacts on quality life.

Язык: Английский

---

Lasso-Based Nomogram for Predicting Early Recurrence Following Radical Resection in Hepatocellular Carcinoma

Journal of Hepatocellular Carcinoma, Год журнала: 2025, Номер Volume 12, С. 539 - 552

Опубликована: Март 1, 2025

Background: Hepatocellular carcinoma (HCC) is a common malignancy with high recurrence rate following curative resection. This study aimed to identify factors contributing early (within 2 years) and develop Lasso-based nomogram for individualized risk assessment. Methods: We conducted retrospective analysis of 206 hCC patients who underwent resection at Taizhou Hospital, Zhejiang Province, from January 2019 August 2022. Patients were randomly divided into training (n=144) validation (n=62) cohorts. Lasso regression was used potential among 17 candidate predictors. A Cox proportional hazards model constructed based on variables selected by Lasso. Model performance assessed using receiver operating characteristic (ROC) curves, calibration plots, decision curve (DCA). Results: Five independent predictors HCC identified: age, serum alanine aminotransferase (ALT) levels, cirrhosis, tumor diameter, microvascular invasion (MVI). The demonstrated area under the (AUC) values recurrence-free survival (RFS) 0.828 (95% confidence interval [CI]: 0.753– 0.904) 1 year, 0.799 CI: 0.718– 0.880) years, 0.742 0.642– 0.842) 5 years in cohort. corresponding AUCs cohort 0.823 0.686– 0.960), 0.804 0.922), 0.857 0.722– 0.992) 1, respectively. Calibration curves DCA confirmed nomogram's accuracy clinical utility. Conclusion: Lasso-Cox effectively predicts within two post-hepatectomy, providing valuable tool personalized postoperative management improve patient outcomes. Keywords: hepatocellular carcinoma, invasion, recurrence, nomogram,

Язык: Английский

---

SLC7A11, a disulfidptosis-related gene, correlates with multi-omics prognostic analysis in hepatocellular carcinoma

European journal of medical research, Год журнала: 2025, Номер 30(1)

Опубликована: Март 12, 2025

This study sought to establish a risk score signature based on disulfidptosis-related genes (DRGs) predict the prognosis of hepatocellular carcinoma (HCC) patients. The expression data DRGs from Cancer Genome Atlas (TCGA) and International Consortium (ICGC) was analyzed develop validate DRG prognostic (DRGPS). In vitro, experiments were conducted explore expressions roles in HCC tissues cell lines. tissue microarrays employed analyze SLC7A11 its association with clinicopathological characteristics. DRGPS consisted 5 (SLC7A11, MATN3, CLEC3B, CCNJL, PON1). survival rate patients high-risk group significantly lower than that low-risk group. also associated modulation tumor microenvironment (TME), mutation burden (TMB), stemness chemosensitivity. Furthermore, pan-cancer analysis suggested immune infiltration multiple cancers. Moreover, our had potential for predicting treatment efficacy Finally, we confirmed downregulation SLC7A11, DRG, inhibited proliferation migration cells, while high correlated advanced TNM clinical stage larger size. systematically describes novel constructed prognosis, providing new approach stratification options. It investigates function contributing further exploration molecular mechanism underlying disulfidptosis HCC, as well therapeutic implications.

Язык: Английский

---