Role of Metabolism in Supporting Immune Responses
Опубликована: Янв. 1, 2025
Язык: Английский
Immuno-cell metabolic changes in HIV-1 infection
Infectious Diseases & Immunity,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
Recent
research
has
shown
that
metabolic
processes
within
immune
cells
are
essential
for
both
human
immunodeficiency
virus
1
(HIV-1)
infection
and
the
response.
Throughout
HIV-1
infection—from
acute
stages
to
chronic
viral
latency—immune
experience
shifts
in
energy
demands
pathways,
paralleling
T-cell
exhaustion.
Dysregulated
metabolism
compromises
cell
function,
leading
dysfunction
persistent
inflammation.
Therefore,
alterations
constitute
a
critical
mechanism
progression
This
review
specifically
explores
profiles
roles
of
T
cells,
monocytes-macrophages,
dendritic
natural
killer
B
at
different
infection,
emphasizing
effects
on
pathways
diverse
types.
These
insights
offer
valuable
therapeutic
strategies
aimed
inhibiting
replication,
restoring
controlling
disease
progression.
Язык: Английский
An excitatory amino acid transporter 1 acts as a novel glutamine transporter and immune modulator in the oyster Crassostrea gigas
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 143127 - 143127
Опубликована: Апрель 1, 2025
Язык: Английский
Enhanced ROS Production and Mitochondrial Metabolic Shifts in CD4+ T Cells of an Autoimmune Uveitis Model
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(21), С. 11513 - 11513
Опубликована: Окт. 26, 2024
Equine
recurrent
uveitis
(ERU)
is
a
spontaneously
occurring
autoimmune
disease
and
one
of
the
leading
causes
blindness
in
horses
worldwide.
Its
similarities
to
autoimmune-mediated
humans
make
it
unique
spontaneous
animal
model
for
this
disease.
Although
many
aspects
ERU
pathogenesis
have
been
elucidated,
remains
not
fully
understood
requires
further
research.
CD4+
T
cells
particular
focus
In
previous
study,
we
showed
metabolic
alterations
from
cases,
including
an
increased
basal
oxygen
consumption
rate
(OCR)
elevated
compensatory
glycolysis.
To
investigate
underlying
reasons
consequences
these
changes,
quantified
reactive
species
(ROS)
production
cases
compared
healthy
controls,
revealing
significantly
higher
ROS
ERU-affected
horses.
Additionally,
aimed
define
mitochondrial
fuel
oxidation
glucose,
glutamine,
long-chain
fatty
acids
(LCFAs)
identified
significant
differences
between
controls.
lower
dependency
on
glucose
greater
flexibility
LCFAs,
indicating
enhanced
ability
switch
alternative
fuels
when
necessary.
Язык: Английский
Research Progress on Energy Metabolism Regulating the Activation of γδT Cells
Pharmacy Information,
Год журнала:
2024,
Номер
13(04), С. 334 - 340
Опубликована: Янв. 1, 2024
Язык: Английский
Unraveling the genetic mysteries of sarcopenia: A bioinformatics approach
Technology and Health Care,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Objective
To
study
the
genetic
expression
of
sarcopenia
using
bioinformatics
methods.
Methods
A
Weighted
Gene
Coexpression
Network
Analysis
(WGCNA)
was
conducted
to
construct
coexpression
networks,
along
with
protein-protein
interaction
networks.
Diagnostic
biomarker
potential
evaluated
receiver
operating
characteristic
curves.
An
analysis
Single-Sample
Set
Enrichment
(ssGSEA)
performed
in
order
determine
amount
immune
cell
infiltration.
We
analyzed
Kyoto
Encyclopedia
Genes
and
Genomes
(KEGG)
pathways
Ontology
(GO)
enrichment
KEGG.
Results
WGCNA
identified
modules
linked
bone
metabolism,
ssGSEA
showed
unique
gene
patterns,
268
genes
were
found
be
differentially
expressed
sarcopenia.
Fourteen
co-expression
related
metabolism
identified,
one
showing
a
strong
positive
correlation.
KEGG
pathway
indicated
downregulation
renin-angiotensin
system
Alzheimer's
disease
pathways.
The
primarily
involved
adipocyte
differentiation.
Conclusion
This
analyzes
changes
patterns
sarcopenia,
providing
insights
into
its
causes
diagnostic
markers
for
future
research
on
treatments.
Язык: Английский