Regulated Cell death in Acute Myocardial Infarction: Molecular Mechanisms and Therapeutic Implications
Ageing Research Reviews,
Год журнала:
2024,
Номер
104, С. 102629 - 102629
Опубликована: Дек. 5, 2024
Язык: Английский
Single-Cell WGCNA Combined with Transcriptome Sequencing to Study the Molecular Mechanisms of Inflammation-Related Ferroptosis in Myocardial Ischemia-Reperfusion Injury
Journal of Inflammation Research,
Год журнала:
2024,
Номер
Volume 17, С. 6203 - 6227
Опубликована: Сен. 1, 2024
Myocardial
ischemia-reperfusion
injury
(MIRI)
is
characterized
by
inflammation
and
ferroptosis,
but
the
precise
mechanisms
remain
unknown.
This
study
used
single-cell
transcriptomics
technology
to
investigate
changes
in
various
cell
subtypes
during
MIRI
regulatory
network
of
ferroptosis-related
genes
immune
infiltration.
Язык: Английский
Qing-Xin-Jie-Yu Granule attenuates myocardial infarction-induced inflammatory response by regulating the MK2/TTP pathway
Jianghan Qi,
Xiaoyao Gao,
Ying Han
и другие.
Pharmaceutical Biology,
Год журнала:
2025,
Номер
63(1), С. 128 - 140
Опубликована: Фев. 21, 2025
Context
Qing-Xin-Jie-Yu
Granule
(QXJYG)
has
shown
promise
in
the
treatment
of
myocardial
infarction.
However,
mechanism
action
QXJYG
underlying
its
anti-inflammation
remain
unknown.
Язык: Английский
Identification and validation of three diagnostic autophagy-related genes associated with advanced plaques and immune cell infiltration in carotid atherosclerosis based on integrated bioinformatics analyses
PeerJ,
Год журнала:
2024,
Номер
12, С. e18543 - e18543
Опубликована: Ноя. 22, 2024
Autophagy
plays
a
key
role
in
the
development
of
carotid
atherosclerosis
(CAS).
This
study
aimed
to
identify
autophagy-related
genes
(ATGs)
related
with
CAS
using
bioinformatics
analysis,
Язык: Английский
Single-cell data revealed the function of natural killer cells and macrophage cells in chemotherapy tolerance in acute myeloid leukemia
PeerJ,
Год журнала:
2024,
Номер
12, С. e18521 - e18521
Опубликована: Ноя. 21, 2024
Background
Acute
myeloid
leukemia
(AML)
is
highly
prevalent
and
heterogeneous
among
adult
acute
leukemias.
Current
chemotherapeutic
approaches
for
AML
often
face
the
challenge
of
drug
resistance,
immune
cells
play
an
important
role
in
regulation
resistance.
Thus,
it
key
significance
to
explore
regulatory
mechanisms
alleviate
chemotherapy
resistance
AML.
Methods
Based
on
single-cell
transcriptomic
data,
this
study
revealed
differences
expression
cell
subpopulations
marker
genes
patients
complete
remission
group
(CR)
compared
non-complete
(non-CR)
after
chemotherapy.
Functional
enrichment
by
clusterprofiler
functions
differentially
expressed
(DEGs)
AUCell
scores
were
used
assess
immunoregulatory
cells.
Pseudotime
analysis
was
construct
differentiation
trajectories.
CellChat
cellular
communication
elucidate
interactions
between
Survival
with
R
package
“survival”
prognosis.
Finally,
wound
healing
trans-well
assay
performed.
Results
Single-cell
clustering
that
NK/T
macrophage
significantly
higher
non-CR
than
CR
FCAR+
FCGR3A+
macrophages
more
active
correlated
processes
regulating
energy
metabolism
activity.
Differentially
NK
groups
mainly
included
HBA1
,
S100A8
S100A9
which
associated
cancer
regulation,
these
(
FCAR
FCGR3A
PREX1
)
upregulated
human
chronic
(HAP1)
silencing
affected
migration
invasion
HAP1
In
particular,
pathways
differed
from
those
group.
Cellular
analyses
showed
ligand-receptor
pairs
HLA-E-KLRK1,
HLA-E-KLRC1,
HLA-E-CD94:NKG2A,
CLEC2B-KLRB1.
addition,
LGALS9-CD45,
CCL3L1-
CCR1,
CCL3-CCR1
two
regulate
secreted
signaling
mediate
progression.
Marker
Conclusion
This
reveals
potential
chemoresistance
through
RNA
sequencing
data.
provides
new
ideas
insights
into
treatment.
Язык: Английский