BCL6 Promotes Transcription of GPR61 to Suppress IL‐1β‐Induced Osteoarthritis Progression in C28/I2 Cells DOI

Guangxuan Zeng,

Yizhou Xu, Zhengnan Li

и другие.

Microbiology and Immunology, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

Abstract Osteoarthritis (OA) is the most common joint disease and its pathogenic mechanism remains to be ensured. This study focused on regulatory relation between B‐cell lymphoma 6 (BCL6) G‐protein‐coupled receptor 61 (GPR61) underlying IL‐1β in OA. Real‐time quantitative polymerase chain reaction western blot were performed for mRNA protein detection. Oxidative injury was assessed by reactive oxygen species (ROS), malondialdehyde (MDA), glutathione (GSH) via kits. Fe 2+ level measured an iron assay kit. Relation analysis BCL6 GPR61 implemented employing ChIP dual‐luciferase reporter assay. downregulated OA samples IL‐1β‐induced C28/I2 cells. cell inflammation, extracellular matrix (ECM) degradation, oxidative stress, ferroptosis all returned overexpression of GPR61. downregulation detected patients IL‐1β‐exposed could promote transcription suppressed progression upregulating The BCL6/GPR61 axis activated PKA/CREB pathway IL‐1β‐treated above results suggested that mitigated induced enhancing BCL6/GPR61/PKA/CREB may considered as a novel OA, has potential act target

Язык: Английский

Research Trends and Dynamics in Single-cell RNA Sequencing for Musculoskeletal Diseases: A Scientometric and Visualization Study DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

International Journal of Medical Sciences, Год журнала: 2025, Номер 22(3), С. 528 - 550

Опубликована: Янв. 1, 2025

Background: Worldwide, approximately 1.7 billion people are afflicted with musculoskeletal (MSK) diseases, posing significant health challenges. The introduction of single-cell RNA sequencing (scRNA-seq) technology provides novel insights and approaches to comprehend the onset, progression, treatment MSK diseases. Nevertheless, there is a remarkable lack analytical descriptive studies regarding trajectory, essential research directions, current situation, pivotal focuses, upcoming perspectives. Therefore, aim this present comprehensive overview advancements made in scRNA-seq for disorders over past 15 years. Methods: It utilizes robust dataset derived from Web Science Core Collection, encompassing January 1, 2009, through September 6, 2024. To achieve this, advanced methodologies were applied conduct thorough scientometric visual analyses. Results: findings underscore preeminent role China, which contributes 63.49% total publications, thereby exerting substantial impact within domain. Notable contributions came institutions such as Shanghai Jiao Tong University, Sun Yat-sen Harvard Medical School, Liu Yun being leading contributor. Frontiers Immunology published greatest number papers field. This study identified joint bone neoplasms, fractures, intervertebral disc degeneration main focuses. Conclusion: extensive analysis benefits both experienced novice researchers by facilitating immediate access critical data, fostering innovation

Язык: Английский

Процитировано

3
Deciphering Epigenetic and Post-Translational Modifications in Ferroptosis: A Scientometric and Visualization Study DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

International Journal of Medical Sciences, Год журнала: 2025, Номер 22(3), С. 508 - 527

Опубликована: Янв. 1, 2025

Background: Recent research emphasizes the significant regulatory functions of epigenetic alterations and post-translational modifications (PTMs) in ferroptosis process. Despite existing volume literature, there is a remarkable shortage comprehensive analyses that systematically trace evolution research, map key investigative routes, evaluate current situation field, determine central themes, predict future directions. This study intends to offer summary progress achieved during past 12 years comprehending how PTMs regulate ferroptosis. Methods: The dataset originated from Web Science, covering period January 1, 2012, May 21, 2024. By employing advanced analytical tools, we carried out an extensive scientometric assessment combination with detailed visual data analysis. Results: results emphasize crucial role China, which contributes 69.59% global output, thereby demonstrating its influence on trajectory this domain. Remarkable productivity manifested at institutions such as Central South University, Shanghai Jiao Tong Zhejiang University. Liu Shuang Tang Daolin stand most productive authors field. journal Cell Death & Disease leads terms publication volume, having published greatest number articles related area. identified hepatocellular carcinoma, mitochondrial diseases, iron overload prominent diseases explored Conclusion: meticulous beneficial both experienced researchers newcomers by providing essential information facilitating derivation innovative concepts

Язык: Английский

Процитировано

2
A bibliometric worldview of breast-conserving surgery for breast cancer from 2013 to 2023 DOI Creative Commons
Siyang Cao, Yihao Wei, Jing Huang

и другие.

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Июль 19, 2024

Over the last decade, significant advancements have been made in breast-conserving surgery (BCS) for breast cancer. However, there is a lack of analytical and descriptive investigations on trajectory, essential research directions, current scenario, pivotal investigative focuses, forthcoming perspectives. The objective this to provide thorough update progress BCS cancer over preceding decade. Retrieved from Web Science database, data span January 1, 2013, November 30, 2023. Utilizing set advanced instruments, we conducted comprehensive bibliometric visual analyses. findings underscore predominant influence USA, representing 35.77% overall publications playing role shaping within field. Notable productivity was evident at various institutions, including Memorial Sloan Kettering Cancer Center, University Texas MD Anderson Toronto.

Язык: Английский

Процитировано

9
A Scientometric Worldview of Artificial Intelligence in Musculoskeletal Diseases Since the 21st Century DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

Journal of Multidisciplinary Healthcare, Год журнала: 2024, Номер Volume 17, С. 3193 - 3211

Опубликована: Июль 1, 2024

Over the past 24 years, significant advancements have been made in applying artificial intelligence (AI) to musculoskeletal (MSK) diseases. However, there is a lack of analytical and descriptive investigations on trajectory, essential research directions, current scenario, pivotal focuses, future perspectives. This aims provide thorough update progress AI for MSK diseases over last years.

Язык: Английский

Процитировано

6
Uncovering the Scientific Landscape: A Bibliometric and Visualized Analysis of Artificial Intelligence in Traditional Chinese Medicine DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

Heliyon, Год журнала: 2024, Номер unknown, С. e37439 - e37439

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

5
Mapping the evolution and research landscape of ferroptosis-targeted nanomedicine: insights from a scientometric analysis DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Сен. 25, 2024

Notable progress has been made in "ferroptosis-based nano drug delivery systems (NDDSs)" over the past 11 years. Despite ongoing absence of a comprehensive scientometric overview and up-to-date scientific mapping research, especially regarding evolution, critical research pathways, current landscape, central investigative themes, future directions.

Язык: Английский

Процитировано

4
A scientometric and visualization analysis of 3D printing scaffolds for vascularized bone tissue engineering over the last decade DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

Regenerative Therapy, Год журнала: 2024, Номер 26, С. 1099 - 1116

Опубликована: Июнь 1, 2024

Язык: Английский

Процитировано

4
Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and ameliorates osteoarthritis progression DOI Creative Commons
Siyang Cao, Yihao Wei,

Ao Xiong

и другие.

Journal of Orthopaedic Translation, Год журнала: 2024, Номер 50, С. 1 - 13

Опубликована: Ноя. 24, 2024

Язык: Английский

Процитировано

1
Association of autoimmune diseases with the occurrence of osteoarthritis: a gene expression and Mendelian randomization study DOI Creative Commons

Dan Jing,

Huai Min Lu,

Xun Zhou

и другие.

Frontiers in Medicine, Год журнала: 2024, Номер 11

Опубликована: Сен. 5, 2024

Observational studies have indicated a potential association between autoimmune diseases and the occurrence of Osteoarthritis (OA), with an increased risk mortality among affected patients. However, whether causal relationship exists two remains unknown.

Язык: Английский

Процитировано

0
Bioinformatics Identification and Experimental Verification of Disulfidptosis-Related Genes in the Progression of Osteoarthritis DOI Creative Commons
Siyang Cao, Yihao Wei, Yaohang Yue

и другие.

Biomedicines, Год журнала: 2024, Номер 12(8), С. 1840 - 1840

Опубликована: Авг. 13, 2024

Osteoarthritis (OA) is a disabling and highly prevalent condition affecting millions worldwide. Recently discovered, disulfidptosis represents novel form of cell death induced by the excessive accumulation cystine. Despite its significance, systematic exploration disulfidptosis-related genes (DRGs) in OA lacking.

Язык: Английский

Процитировано

0