The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases DOI Creative Commons
Yuxin Zhang, Meijuan Zou, Hao Wu

и другие.

Neurobiology of Disease, Год журнала: 2024, Номер 202, С. 106710 - 106710

Опубликована: Окт. 28, 2024

Neurodegenerative diseases (NDs) are a type of common chronic progressive disorders characterized by damage to specific cell populations in the nervous system, ultimately leading disability or death. Effective treatments for these still lacking, due limited understanding their pathogeneses, which involve multiple cellular and molecular pathways. The triggering an immune response is feature neurodegenerative disorders. A critical challenge intricate interplay between neuroinflammation, neurodegeneration, responses, not yet fully characterized. In recent years, cyclic GMP-AMP synthase (cGAS)-stimulator interferon gene (STING) pathway, crucial intracellular DNA sensing, has gradually gained attention. However, roles this pathway within types such as cells, glial neuronal its contribution ND pathogenesis, remain elucidated. review, we systematically explore how cGAS-STING signaling links various with related effector pathways under context NDs multifaceted therapeutic directions. We emphasize discovery condition-dependent heterogeneity integral diverse responses potential targets. Additionally, review pathogenic role activation Parkinson's disease, ataxia-telangiectasia, amyotrophic lateral sclerosis. focus on complex bidirectional Alzheimer's Huntington's sclerosis, revealing double-edged nature disease progression. objective elucidate pivotal pathogenesis catalyze new insights facilitating development novel strategies.

Язык: Английский

Lysosome-Mitochondrial Crosstalk in Cellular Stress and Disease DOI Creative Commons

Szilvia Kiraly,

Jack Stanley, Emily R. Eden

и другие.

Antioxidants, Год журнала: 2025, Номер 14(2), С. 125 - 125

Опубликована: Янв. 22, 2025

The perception of lysosomes and mitochondria as entirely separate independent entities that degrade material produce ATP, respectively, has been challenged in recent years not only more complex roles for both organelles, but also an unanticipated level interdependence are being uncovered. Coupled lysosome mitochondrial function dysfunction involve crosstalk between the two organelles which goes beyond quality control lysosome-mediated clearance damaged through mitophagy. Our understanding these essential metabolic transformed by major advances field membrane contact sites biology. We now know play central inter-organelle communication. This importance mitochondria–lysosome contacts (MLCs) cellular homeostasis, evinced growing number diseases have associated with their dysregulation, is starting to be appreciated. How MLCs regulated how coordination other pathways lysosome–mitochondria achieved subjects ongoing scrutiny, this review explores current governing its impact on stress disease.

Язык: Английский

Процитировано

0
The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellular and molecular mechanisms in neurodegenerative diseases DOI Creative Commons
Yuxin Zhang, Meijuan Zou, Hao Wu

и другие.

Neurobiology of Disease, Год журнала: 2024, Номер 202, С. 106710 - 106710

Опубликована: Окт. 28, 2024

Neurodegenerative diseases (NDs) are a type of common chronic progressive disorders characterized by damage to specific cell populations in the nervous system, ultimately leading disability or death. Effective treatments for these still lacking, due limited understanding their pathogeneses, which involve multiple cellular and molecular pathways. The triggering an immune response is feature neurodegenerative disorders. A critical challenge intricate interplay between neuroinflammation, neurodegeneration, responses, not yet fully characterized. In recent years, cyclic GMP-AMP synthase (cGAS)-stimulator interferon gene (STING) pathway, crucial intracellular DNA sensing, has gradually gained attention. However, roles this pathway within types such as cells, glial neuronal its contribution ND pathogenesis, remain elucidated. review, we systematically explore how cGAS-STING signaling links various with related effector pathways under context NDs multifaceted therapeutic directions. We emphasize discovery condition-dependent heterogeneity integral diverse responses potential targets. Additionally, review pathogenic role activation Parkinson's disease, ataxia-telangiectasia, amyotrophic lateral sclerosis. focus on complex bidirectional Alzheimer's Huntington's sclerosis, revealing double-edged nature disease progression. objective elucidate pivotal pathogenesis catalyze new insights facilitating development novel strategies.

Язык: Английский

Процитировано

3