Remnant cholesterol inflammatory index and its association with all-cause and cause-specific mortality in middle-aged and elderly populations: evidence from US and Chinese national population surveys DOI Creative Commons
Yifei Wang, Lei Bi, Qing Li

и другие.

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 24, 2025

The remnant cholesterol inflammatory index (RCII) is a novel metric that combines and high-sensitivity C-reactive protein, reflecting the metabolic risk. This study investigates association between RCII long-term risks of all-cause cause-specific mortality in middle-aged elderly populations US China. We analyzed data from National Health Nutrition Examination Survey (NHANES) China Retirement Longitudinal Study (CHARLS), including 7,565 12,932 participants aged 45 years older, respectively. were categorized into quartiles based on natural log-transformed (lnRCII) values. Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic splines (RCS) mediation analysis used to examine relationship lnRCII outcomes, adjusting for potential covariates. mean age was 59.90 ± 10.44 58.64 9.78 with 53.28% 52.50% female, showed higher (≥ 0.79 NHANES, ≥ -0.13 CHARLS) significantly associated increased risk (p < 0.001). Each standard deviation (SD) increase corresponded mortality, hazard ratios (HRs) 95% confidence interval (CI) 1.29 (95% CI: 1.21-1.36) NHANES 1.26 1.15-1.38) CHARLS. In also elevated cardiovascular (HR = 1.21, 1.08-1.35) cancer 1.30, 1.09-1.55). RCS indicated J-shaped both linear mortality. Mediation systolic blood pressure fasting plasma glucose partially mediated these associations. Subgroup analyses suggested stronger interaction 0.010). Elevated levels are population, By integrating factors, may serve as valuable tool stratification clinical decision-making.

Язык: Английский

Remnant cholesterol inflammatory index and its association with all-cause and cause-specific mortality in middle-aged and elderly populations: evidence from US and Chinese national population surveys DOI Creative Commons
Yifei Wang, Lei Bi, Qing Li

и другие.

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 24, 2025

The remnant cholesterol inflammatory index (RCII) is a novel metric that combines and high-sensitivity C-reactive protein, reflecting the metabolic risk. This study investigates association between RCII long-term risks of all-cause cause-specific mortality in middle-aged elderly populations US China. We analyzed data from National Health Nutrition Examination Survey (NHANES) China Retirement Longitudinal Study (CHARLS), including 7,565 12,932 participants aged 45 years older, respectively. were categorized into quartiles based on natural log-transformed (lnRCII) values. Kaplan-Meier survival analysis, Cox proportional hazards models, restricted cubic splines (RCS) mediation analysis used to examine relationship lnRCII outcomes, adjusting for potential covariates. mean age was 59.90 ± 10.44 58.64 9.78 with 53.28% 52.50% female, showed higher (≥ 0.79 NHANES, ≥ -0.13 CHARLS) significantly associated increased risk (p < 0.001). Each standard deviation (SD) increase corresponded mortality, hazard ratios (HRs) 95% confidence interval (CI) 1.29 (95% CI: 1.21-1.36) NHANES 1.26 1.15-1.38) CHARLS. In also elevated cardiovascular (HR = 1.21, 1.08-1.35) cancer 1.30, 1.09-1.55). RCS indicated J-shaped both linear mortality. Mediation systolic blood pressure fasting plasma glucose partially mediated these associations. Subgroup analyses suggested stronger interaction 0.010). Elevated levels are population, By integrating factors, may serve as valuable tool stratification clinical decision-making.

Язык: Английский

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