SARS-CoV-2 seroprevalence and associated factors, based on HIV serostatus, in young people in Sofala province, Mozambique

BMC Infectious Diseases, Год журнала: 2023, Номер 23(1)

Опубликована: Ноя. 17, 2023

In Sofala province (Mozambique), young people living with HIV (YPLHIV) are estimated at 7% among aged 15-24 years. Even though the COVID-19 pandemic threatened health services, data on impact of YPLHIV lacking. This study aimed exploring seroprevalence SARS-CoV-2 and associated factors based their status.A cross-sectional was conducted, including 18-24 attending a visit one adolescent-friendly services in between October November 2022. People vaccinated against SARS-COV-2 or WHO stage III-IV were excluded. A antibodies qualitative test questionnaire investigating socio-demographic clinical characteristics proposed. calculated Clopper-Pearson method. The odds ratio (OR) positive through multivariable binomial logistic regression.In total, 540 65.8% women 16.7% participated survey.. mean age 20.2 years (SD 2.0). Almost all sample (96.1%) reported adopting least preventive measure for COVID-19. weighted whole 46.8% (95%CI 42.6-51.2) 35.9% 25.3-47.5) YPLHIV. adjusted OR testing higher students compared to workers (aOR:2.02[0.95CI 1.01-4.21]) those symptoms (aOR:1.52[0.95CI 1.01-2.30]). There no differences status(aOR:0.663[95%CI 0.406-1.069]). Overall, by 68 (28.2%) serological 7 (21.7%) (p = 0.527). No required hospitalization.SARS-CoV-2 without risk infection presentation status. result may be influenced exclusion advanced disease. suggests schools' role spreading virus. It's important continue monitoring better understand its effect screening adherence treatment.

Язык: Английский

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Malaria and Autoimmunity

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 675 - 691

Опубликована: Янв. 1, 2024

Язык: Английский

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Health behavior and social crisis in the era of COVID-19 in Malawi: A decolonizing approach to a qualitative study

Nursing Outlook, Год журнала: 2024, Номер 73(1), С. 102317 - 102317

Опубликована: Ноя. 23, 2024

The rapid spread and severity of COVID-19 brought major health challenges dealt a heavy blow to key services daily life in Africa, including Malawi.

Язык: Английский

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“Kuteteza”: A community-engaged COVID-19 Prevention and Protection Initiative in Southern Malawi

Wellcome Open Research, Год журнала: 2024, Номер 9, С. 24 - 24

Опубликована: Фев. 12, 2024

Background The COVID-19 epidemic in Malawi involved almost 90,000 recorded cases and 2,638 deaths. Data suggest that the developed largely urban settings, but extent of rural spread – exposing older adults particular is unclear. This concern led us, to develop ‘Kuteteza’ partnership project: a community-based Public Health intervention involving shielding additional strategies mitigate impacts Malawi. We now present results realist project evaluation. Methods Clinicians, professionals, researchers collaborated with government district level staff two districts. After engagement local structures, willing (>60 years) their communities made arrangements for supported 'shielding'. Masks, handwashing stations, soap were also provided, partnerships allowed support vulnerable groups. Finally, context-responsive community reinforced prevention during peak risk periods. Our evaluation included collation anonymised descriptive data qualitative structured observations focus groups members volunteers each setting. Results 25 villages. Multi-level stakeholder was pivotal developing establishing work, strong District Office integral implementation. Team contributed national meetings, aligning guidance actions. Established relevant ministries resulted incorporation response plan. In Kuteteza villages, stations used, there awareness measures. Further experiences are presented, including learning points future outbreak responses. Conclusions Through effective contribution strategy, raised populations at critical time pandemic. These approaches can be incorporated emergency responses.

Язык: Английский

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Healthcare-seeking behavior among people with HIV undergoing TB screening during the COVID-19 pandemic

Deleted Journal, Год журнала: 2024, Номер 1(7), С. 323 - 325

Опубликована: Июль 1, 2024

Язык: Английский

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“Kuteteza”: A community-engaged COVID-19 Prevention and Protection Initiative in Southern Malawi

Wellcome Open Research, Год журнала: 2024, Номер 9, С. 24 - 24

Опубликована: Окт. 2, 2024

Background The COVID-19 epidemic in Malawi involved almost 90,000 recorded cases and 2,638 deaths. In response to early concerns about vulnerable older people rural areas, we developed ‘Kuteteza’: a mitigation project. Clinicians, public health professionals, researchers collaborated with government district-level staff two Southern districts. Interventions included supported ‘shielding’ of – minimising social mixing whilst having their daily needs supported. Additional strategies provision masks, handwashing stations, soap. Government partnerships allowed additional support for groups. We present the findings realist project evaluation, assessing feasibility this approach. Methods collated anonymised descriptive data on Kuteteza procedures conducted qualitative structured observations villages initiative. carried out three focus groups involving community members, frontline staff, volunteers each setting. These provided deeper insights into experiences pandemic impacts intervention, including suggested opportunities during future outbreaks. Results 25 across districts, 1,087 over age 60 voluntarily participating ‘shielding’. Supplies food, water, cooking fuel were mostly arranged within family. villages, stations soap widely used, there was awareness some observance prevention measures. project, supplies, greatly appreciated by communities, but wider contextual constraints namely widespread economic insecurity presented persisting challenges. Suggestions improvement largely concerned enhancements extensions. Conclusions Through effective stakeholder engagement contribution national strategy, helped raise populations at critical time pandemic. approaches welcomed locally may be incorporated responses. Supported should paired government-led measures mitigate hardship.

Язык: Английский

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The COVID-19 pandemic and economic recovery: The mediating role of governance, a global perspective

Heliyon, Год журнала: 2024, Номер 10(22), С. e39869 - e39869

Опубликована: Окт. 28, 2024

The COVID-19 pandemic, arguably the most extensive economic shock after Great Depression, has drawn attention from policy custodians over past three years. Governments' response brought to limelight role that governance plays in mitigating shrinking effects of a pandemic. This study investigated mediating post-pandemic recovery process using structural equation modelling cross-sectional data 125 countries for years 2020 and 2021. results show did not mediate at global level. However, regional analysis reveals full mediation effect Africa low-income Disaggregating by indicators complete control corruption, government effectiveness, regulatory quality, rule law. Achieving sustainable requires strengthening local structures encouraging international cooperation. research motivates establishment institutions spirit United Nations-driven frameworks. can be complemented country-specific, multi-agency, cross-sector collaborations led state, development systems reduce mistrust among stockholders, investment artificial intelligence e-governance systems.

Язык: Английский

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Kinetics of naturally induced binding and neutralising anti-SARS-CoV-2 antibody levels and potencies among SARS-CoV-2 infected Kenyans with diverse grades of COVID-19 severity: an observational study

Wellcome Open Research, Год журнала: 2024, Номер 8, С. 350 - 350

Опубликована: Дек. 2, 2024

Background Given the low levels of coronavirus disease 2019 (COVID-19) vaccine coverage in sub-Saharan Africa (sSA), despite high natural severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exposures, strategies for extending breadth and longevity naturally acquired immunity are warranted. Designing such will require a good understanding immunity. Methods We measured whole-spike immunoglobulin G (IgG) spike-receptor binding domain (RBD) total immunoglobulins (Igs) on 585 plasma samples collected longitudinally over five successive time points within six months COVID-19 diagnosis 309 patients. antibody-neutralising potency against wild-type (Wuhan) SARS-CoV-2 pseudovirus subset 51 patients three points. Binding neutralising antibody potencies were then tested correlations with severities. Results Rates seroconversion increased from day 0 (day PCR testing) to 180 (six months) (63.6% 100 %) (69.3 % 97%) anti-spike-IgG anti-spike-RBD Igs, respectively. Levels these antibodies peaked at 28 (p<0.01) subsequently maintained without significant decay (p>0.99). Similarly, but declined by three-fold, after (p<0.01). highly correlated all analysed (r>0.60, p<0.01). severity. Conclusions Most generated specific that remained stable first infection. However, respective decayed three-fold month-six suggesting they short-lived, consistent what has been observed elsewhere world. Thus, regular vaccination boosters required sustain anti-SARS-CoV-2 our population.

Язык: Английский

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Kinetics of naturally induced binding and neutralizing anti-SARS-CoV-2 antibody levels and potencies among Kenyan patients with diverse grades of COVID-19 severity

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Окт. 5, 2022

Abstract Background Given the low levels of COVID-19 vaccine coverage in Sub-Saharan Africa, despite high natural SARS-CoV-2 exposures, strategies for extending breadth and longevity naturally acquired immunity are warranted. Designing such will require a good understanding immunity. Methods We used ELISA to measure whole-spike IgG spike-receptor binding domain (RBD) total immunoglobulins (Igs) on 585 plasma samples collected longitudinally over five successive time points within six months diagnosis 309 patients. measured antibody neutralizing potency against wild-type (Wuhan) pseudo-virus subset 51 patients three points. Binding potencies were then tested correlations with severities, graded according National Institute Health (NIH), USA criteria. Results Rates sero-conversion increased from Day 0 (day PCR testing) 180 (six months) (63.6% 100 %) (69.3 % 97%) anti-spike anti-spike-RBD Igs, respectively. Levels these antibodies peaked at 28 (P<0.0001) subsequently maintained without significant decay (p>0.99). Similarly, (p<0.0001) but had decreased by three-folds, after (p<0.0001). highly correlated all analyzed (r>0.6, P<0.0001). disease severity. Conclusion Most Africa generate specific that remain stable during first infection. Although directly correlated, respective decayed three-fold sixth month suggesting they short-lived, consistent what has been observed elsewhere. Thus, just like other populations, regular vaccination boosters be required broaden sustain predominantly anti-SARS-CoV-2 antibodies.

Язык: Английский

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What Happened to Ethiopian Youth during the Covid-19 Pandemic?

Comparative Sociology, Год журнала: 2022, Номер 21(6), С. 651 - 676

Опубликована: Дек. 15, 2022

Abstract The purpose of this qualitative study was to investigate Ethiopian urban youth’s changing risk beliefs, contributing factors, and global south lessons in relation the COVID -19 pandemic. Researchers conducted in-depth interviews focus group discussions with youth Ethiopia’s East-Gojjam district. findings revealed three major stages perception: high perceived stage associated early pandemic outbreaks, steady decline economic stress that outweighed health risk, zero when all safety measures appear have been completely abandoned. government’s self-contradictory rhetoric practice, contradiction between religious teachings scientific messages, misinformation social media are factors for evolved beliefs. A lesson from is active participation key stakeholders bridging gap government society.

Язык: Английский

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