Circulating Microrna-146a as A Biomarker Related To Inflammation in Thalasemia Patients DOI Creative Commons

Heba Hani Hamzah,

Nawal Khinteel Jabbar

Academia Open, Год журнала: 2023, Номер 9(2)

Опубликована: Окт. 11, 2023

This study delves into the intricate realm of microRNAs (miRNAs), non-coding RNA molecules that wield significant influence in pathogenesis various disorders. With advent advanced technologies, accurate quantification miRNA abundance across diverse tissues is now attainable. Notably, extracellular circulating microparticles have emerged as robust, stable indicators for blood-based disease diagnostics. investigation explores dynamic interplay between and clinical phenotypes, offering valuable insights intricacies. The research narrows its focus to recent developments employing biomarkers prevalent inflammatory disorders, including infections endemic thalassemia patients city Diwaniyah, Iraq. Current findings paint a promising future utilization management diseases. In conclusion, this comprehensive exploration miRNA's regulatory role globin gene expression has potential revolutionize landscape thalassemia, ameliorating manifestations symptoms debilitating hemoglobinopathy. identification miRNAs implicated disease's pathophysiology not only paves way novel diagnostic markers but also opens new horizons therapeutic interventions. Highlights : MiRNA Significance: MicroRNAs play pivotal mechanisms. Circulating Microparticles: Extracellular are indicators, holding promise diagnostics management, especially context Thalassemia Insights: highlights impact on expression, avenues diagnosis treatment Keywords Microparticles, Thalassemia, Inflammatory Disorders, Disease Diagnostics

Язык: Английский

Nursing interventions for improving quality of life among parents with major Thalassemic children: a scoping review DOI Creative Commons
Ai Mardhiyah, Iyus Yosep, Sri Hendrawati

и другие.

BMC Nursing, Год журнала: 2025, Номер 24(1)

Опубликована: Март 26, 2025

Язык: Английский

Процитировано

0
Effectiveness of the application of an educational program based on the Theory of Planned Behavior (TPB) in adopting preventive behaviors among mothers who have thalassemia children in Iran: a randomized controlled trial DOI Creative Commons
Iraj Zareban,

Zahra Oudi-Akbari,

Mohammad Saeed Jadgal

и другие.

Egyptian Journal of Medical Human Genetics, Год журнала: 2024, Номер 25(1)

Опубликована: Апрель 2, 2024

Abstract Background Thalassemia is one of the most common chronic diseases, which cause many problems for patients, families, and health system. The aim this study was to evaluate effectiveness application an educational program based on Theory Planned Behavior in adopting preventive behaviors from thalassemia. Methods This randomized controlled trial associated with participation 160 mothers children suffering thalassemia major, who were divided into two groups including intervention control. Demographic information, knowledge, data related constructs collected. Data analyzed using SPSS16 software descriptive analytical tests. Results mean scores perceived behavioral control, intention, behavior group pre-intervention phase 9.83 ± 1.45, 9.1 21.32, 2.1 18.42, respectively. stage after increased 12.00 0.00, 11.51 0.59, 5 0.37.95, respectively, difference means stages significant ( P value < 0.0001). But no change observed control > 0.05). Conclusion results showed effect training promotion major.

Язык: Английский

Процитировано

2
Gender Disparities in Psychological Disturbances and Quality of Life Among Adolescent and Adult Patients with Thalassemia: A Review DOI Creative Commons
Pandji Irani Fianza, Anita Rahmawati, Indra Wijaya

и другие.

Journal of Multidisciplinary Healthcare, Год журнала: 2024, Номер Volume 17, С. 1663 - 1669

Опубликована: Апрель 1, 2024

Thalassemia is a chronic disease caused by impaired globin chain synthesis, leading to ineffective erythropoiesis, hemolysis, and anemia.The treatment of patients with thalassemia, including blood transfusion combined chelation therapy has progressed improved their survival prognosis.However, thalassemia-related psychological problems health-related quality life (QoL) challenges still exist.Gender one the factors that been suggested, contribute disparities in outcomes.This review article examined evidence for gender differences disturbances QoL adolescent adult thalassemia.A non-systematic search literature was conducted PubMed Google Scholar English full-text available from 2013 2023.We identified 23 studies sample size ≥ 100 anxiety, depression, thalassemia (mean prevalence female = 53.1%;mean age 28 years).Our shows there are distress thalassemia.Statistically significant were demonstrated 62% outcomes 16 studies.Female had higher poorer some studies.However, further sufficient power design necessary confirm existence outcomes.

Язык: Английский

Процитировано

1
Exploring experiences of mothers of children with thalassemia major in Indonesia: A descriptive phenomenological study DOI Creative Commons
Nelly Hermala Dewi, Setyowati Setyowati, Enie Novieastari

и другие.

Belitung Nursing Journal, Год журнала: 2024, Номер 10(5), С. 585 - 592

Опубликована: Окт. 15, 2024

Thalassemia is a hereditary blood disorder that poses significant challenges for affected children and their families. Caregivers, particularly mothers, often experience difficulties in managing child's condition. Understanding current crucial improving care support.

Язык: Английский

Процитировано

1
Effect of Educational Program Based on the Precede-Proceed Planning Model on Quality of Life of Children with Thalassemia DOI Open Access

Hanan Nabawy Elaaser,

Hanaa Tharwat Mohamed El-shahat,

Reda Mohamed Abduallah

и другие.

Journal of Nursing Science Benha University/Journal of Nursing Science Benha University , Год журнала: 2023, Номер 4(2), С. 124 - 146

Опубликована: Окт. 1, 2023

Background: Thalassemia is an inherited blood disorder affecting hemoglobin synthesis that can actually affect the quality of life children due to disease and provided treatment. Aim study was evaluate effect educational program based on precede-proceed planning model with thalassemia. Design: A quasi-experimental design used. Setting: This conducted at Pediatric Hematology Unit out-Patient Clinic Benha Specialized Hospital affiliated Egyptian Ministry Health Population Secretory Medical Centers City. Subjects: purposive sample 125 children. Tools data collection: Two tools were used; Tool I: structured interviewing questionnaire involving five parts; Part (1) Characteristics studied children, (2) history (3) Predisposing factors assessment questionnaire, (4) Reinforcement (5) Enabling II: Quality Life Inventory Generic core scale. Results: Less than one quarter less three quarters had high pre-and post-intervention phases respectively. While, 12.8% them low Conclusion: Children thalassemia higher scores after implementation precede–proceed model. Recommendations: Integrating in designing intervention programs pediatric hematology units.

Язык: Английский

Процитировано

2
Investigation of the Relationship between Thalassemia and Depression to Predict a Base for Rehabilitation Measures DOI Creative Commons

Maryam Maryam,

Abdur Rahman, Sajjad Haider

и другие.

Deleted Journal, Год журнала: 2024, Номер 3(5)

Опубликована: Май 22, 2024

This study examines the relationship between thalassemia, an inherited blood disorder, and depression, a psychologically debilitating illness. Thalassemia, which is characterized by insufficient hemoglobin production, significantly affects quality of life well-being patients. As more effective treatment even cure for thalassemia have become possible, attention being drawn to assessment common among those affected. In addition investigating depression this research also aims provide basis patient rehabilitation. The conducted with sample 60 subjects consisting non-thalassemia children aged 4 14 years from different areas province. Beck Depression Inventory scale’s second revision has been used purpose. results confirmed hypothesis that there positive correlation depression. Statistical analysis was performed using SPSS t -test revealed significant level comorbidity calculated coefficient alpha 0.768, mean 41.40, standard deviation (SD) 2.009, Cohen’s d 0.188, significance 0.50. These are consistent previous Iranshahr Institute (2014-2015) indicating marked occurrence in needed overall understand mental health problems thalassemia. However, scope limited local hospital challenges such as language barriers cultural stigma. Despite these limitations, highlights need further on patients suggests avenues future therapeutic rehabilitation interventions. addition, topic can be researched, diseases pose great dealing It help parents support suffering child coping psychological burden physical

Язык: Английский

Процитировано

0
A Questionnaire Study to Compare The Role of Nursing and Medical Laboratory Staff in Promoting Awareness About Thalassemia DOI Open Access

Muh. Resky Febriyanto Zul Fadli Mustafa

Journal of Scientific Research in Medical and Biological Sciences, Год журнала: 2024, Номер 5(2), С. 01 - 12

Опубликована: Май 15, 2024

Introduction: One of the most common genetically transmitted blood disorders is thalassemia. Hematology a matter great concern, warranting global awareness and understanding among healthcare professionals. We aim to highlight roles nursing medical laboratory employees in task spreading information about thalassemia through this research, which has taken self-reporting survey. Methods: More staff also were interviewed evaluate their knowledge thalassemia, perception role care, level involvement with education activities on issue. Data analysis, for example, correlation hypothesis testing, been done study look group differences. Results: The results demonstrated that levels lab very varied themselves. Medical had greater there nurses who considered job caring more positively. Conclusions: Increased increased educational seminars would help increase provide better patient care services. can be used training personnel comprehensive patients.

Язык: Английский

Процитировано

0
Impact of Dedicated Thalassemia Day Care Services: Pediatric Hematologist’s Perspective DOI
Ritika Khurana, Purva Kanvinde,

Parth Ganatra

и другие.

Indian Journal of Hematology and Blood Transfusion, Год журнала: 2024, Номер 41(1), С. 102 - 106

Опубликована: Июль 27, 2024

Язык: Английский

Процитировано

0
The Correlation Between Family Support with The Quality of Life of School-Age Children with Thalassemia DOI Creative Commons

Kili Astarani,

Laurensia Yuli F.W,

Sutik

и другие.

Babali Nursing Research, Год журнала: 2024, Номер 5(3), С. 484 - 494

Опубликована: Июль 31, 2024

Introduction: Thalassemia is a severe disease affecting many school-aged children, characterized by symptoms such as weakness and paleness due to low hemoglobin levels. These children often require routine blood transfusions, which can lead several side effects impacting their quality of life. Generally, the life for with thalassemia lower than that healthy peers. Family support one factor influence thalassemia. This study investigated relationship between family in at Immanuel Way Halim Hospital, Bandar Lampung.Methods: The research design was descriptive-analytic cross-sectional approach. sample included all patients Edelweiss Hospital room Halim, totaling 28 respondents. sampling technique used purposive sampling, inclusion criteria being (ages 7 18 years) who could communicate well. Data analysis conducted using Chi-square test.Results: results indicated 19 respondents (67.9%) had positive support, 14 (50%) high Statistical showed p-value 0.027 (<0.05).Conclusion: There significant Lampung.

Язык: Английский

Процитировано

0
Hubungan Antara Tingkat Kesadaran Orang Tua dengan Perilaku Pencegahan Berulang Thalasemia DOI Creative Commons
Ai Mardhiyah, Aat Sriati, Ayu Prawesti

и другие.

Jurnal Obsesi Jurnal Pendidikan Anak Usia Dini, Год журнала: 2023, Номер 7(4), С. 4848 - 4856

Опубликована: Сен. 1, 2023

Prevalensi penyakit thalassemia di Jawa Barat mengalami peningkatan setiap tahunnya. Program pencegahan sekunder thalasemia yaitu pada keluarga yang beresiko atau dicurigai sebagai pembawa sifat untuk mencegah terjadi kembali kelahiran dengan mayor. Tujuan penelitian ini mengidentifikasi hubungan antara kesadaran orang tua anak penderita prilaku thalasemia. Desain adalah cross-sectional study sampel sejumlah 114 Pengumpulan data menggunakan instrumen dan dalam talasemia. Analisis uji korelasional melalui Chi Square. Hasil menunjukkan bahwa tidak terdapat thalassemia, kemungkinan adanya faktor-faktor penghambat hampir setengahnya sudah mempunyai tetapi berprilaku dikarenakan biaya, kurang memahami prosedur, takut, masih berharap punya kembali. Saran perlu meningkatkan mengembangkan intervensi strategi konseling peer support group tua.

Процитировано

0