Pharmacotherapeutics of Musculoskeletal Orofacial Pain

Journal of the California Dental Association, Год журнала: 2025, Номер 53(1)

Опубликована: Янв. 7, 2025

Язык: Английский

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Effects of Adding Tizanidine on Stimulants in Treatment of ADHD: A Randomized, Double-Blind, Placebo-Controlled Trial

Journal of Comprehensive Pediatrics, Год журнала: 2025, Номер 16(1)

Опубликована: Янв. 26, 2025

Background: Attention deficit hyperactivity disorder (ADHD) is defined as a neurodevelopmental and one of the most common psychiatric disorders in children adolescents. Various treatments have been recommended to manage this disorder, including stimulants non-stimulants. Stimulants are first-line treatment strategy for ADHD; however, approximately 30% patients exhibit drug resistance or sensitivity these medications. Consequently, other groups, such Alpha2 agonists, used cases. Clonidine guanfacine Food Drug Administration (FDA)-approved drugs ADHD, they belong group. Tizanidine an agonist that has not yet studied disorder. Objectives: Due lack information studies area, purpose study investigate effects adding tizanidine ADHD. Methods: This research was double-blind, placebo-controlled, randomized trial conducted outpatient units admission wards university hospitals. Forty aged 6 18 years, with at least month unsuccessful ADHD lisdexamfetamine (Vyvanse), participated study. The participants received either Vyvanse (group 1, n = 20) alone 2, 19) 8-week period. Symptom severity improvement assessed using CONNERS' Parent Rating Scale-48 (CPRS-48) Swanson, Nolan, Pelham Scale (SNAP-IV). Safety measurements were pulse rate, blood pressure, electrocardiogram (ECG) changes during Results: During follow-up, SNAP-IV measures did change significantly two groups. A significant within-group observed only conduct domain CPRS-48 (P < 0.05). Conclusions: Adding effective but demonstrates sufficient safety use pediatric age

Язык: Английский

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Back pain: empirical and personalized approach to drug therapy. Conclusion of the Expert Council of the Russian Society for the Study of Pain

Russian Journal of Pain, Год журнала: 2025, Номер 23(1), С. 92 - 92

Опубликована: Март 13, 2025

Objective. To present the recommendations of expert council Russian Society for Study Pain on “Dorsumio” drug in treatment chronic nonspecific back pain (CNBP). Key points. Currently, CNBP is leading disease associated with disability worldwide. Patients often experience concomitant depressive and anxiety symptoms complicating course therapy, as well worsening quality life working capacity. Various problems care include not only impact pathogenesis pain, but also depression, anxiety, insomnia, assessment compatibility various drugs patient adherence to therapy. The new (mirtazapine 15 mg + tizanidine 6 mg) can influence mechanisms provide effective therapy patients due complex analgesic, muscle relaxant, antidepressant anti-anxiety effects.

Язык: Английский

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Myofascial Pain Syndrome: An Update on Clinical Characteristics, Etiopathogenesis, Diagnosis, and Treatment

Muscle & Nerve, Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

ABSTRACT Myofascial pain syndrome (MPS) is a chronic regional condition characterized by trigger points—hyperirritable spots within taut bands of muscle fibers that cause both localized and referred pain. The pathogenesis, diagnostic criteria, classification MPS are still under investigation, which complicates the development standardized treatment protocols. Although tools have improved, often remains underrecognized due to symptom overlap with other disorders, such as fibromyalgia, neuropathic pain, joint disorders. Factors contributing its onset persistence include overuse, postural imbalance, systemic conditions, psychological behavioral influences. This narrative review explores primary risk factors, current hypotheses on diagnosis differential diagnosis, conventional emerging treatments. Sufficient evidence supports use local anesthetic injections for MPS. Some suggests dry needling, acupuncture, magnetic stimulation, ultrasound therapy, laser extracorporeal shock wave manual therapy may be effective, particularly compared sham or placebo. However, non‐steroidal anti‐inflammatory drugs, diclofenac, botulinum toxin, transcutaneous electrical nerve stimulation show insufficient evidence, while effectiveness relaxants, antidepressants, gabapentin, opioids, topical lidocaine, capsaicin, EMLA cream, kinesio taping inconclusive. Effective management requires patient‐centered approach integrates empirically supported evidence‐based treatments tailored individual needs. synthesizes understanding highlights need high‐quality research improve clinical decision‐making in managing this complex condition.

Язык: Английский

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Multivalent effect on chronic back pain: results of randomized clinical trials of Dorsumio

Russian Journal of Pain, Год журнала: 2024, Номер 22(3), С. 63 - 63

Опубликована: Янв. 1, 2024

Язык: Английский

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