The Interplay of Microbiota, Long COVID, and Musculoskeletal Pain: A Narrative Review DOI Creative Commons
Leila Simorgh, Rozita Hedayati,

Mina Sadat Mirshoja

и другие.

Deleted Journal, Год журнала: 2024, Номер 1(2)

Опубликована: Сен. 1, 2024

Context: Long COVID, a condition that persists after the acute phase of COVID-19, poses significant burden, with 10 - 45% recovered patients experiencing persistent symptoms. Among these, approximately 46% report musculoskeletal pain. This narrative review explores potential connections between gut microbiota, and pain, aiming to introduce new therapeutic avenues preventive strategies for managing symptoms in COVID patients. Evidence Acquisition: A comprehensive search was conducted using Google Scholar, Lens.org, ConnectedPaper.com identify relevant articles published 2019 2024. Keywords related pain were used. Articles selected based on predefined inclusion exclusion criteria, their quality assessed. Data from synthesized provide an overview interplay Results: Recent research highlights role microbiota modulating immune responses systemic inflammation. Dysbiosis has been linked severity progression COVID-19 persistence Individuals often experience new-onset manifestations, such as joint myalgia, chronic Additionally, dysbiosis associated conditions like lower back knee osteoarthritis. suggests relationship problems general may also extend patients, indicating broader implications outcomes. Therapeutic targeting probiotics, prebiotics, dietary interventions, have shown promise these improving overall health Conclusions: The evidence underscores importance understanding microbiota-musculoskeletal nexus COVID. Gut contributes inflammation, exacerbating associations other emphasize need microbiota-targeted strategies. Future should focus elucidating mechanisms linking exploring gut-brain axis, developing personalized approaches modulate microbiota. Advancing our this can pave way innovative address complex challenges posed by conditions.

Язык: Английский

New-Onset Chronic Musculoskeletal Pain Following COVID-19 Infection Fulfils the Fibromyalgia Clinical Syndrome Criteria: A Preliminary Study DOI Creative Commons
Omar Khoja, Matthew R Mulvey, Sarah Astill

и другие.

Biomedicines, Год журнала: 2024, Номер 12(9), С. 1940 - 1940

Опубликована: Авг. 23, 2024

New-onset chronic musculoskeletal (MSK) pain (>3 months duration) is a common symptom of post-COVID-19 syndrome (PCS). This study aimed to characterise new-onset MSK in patients with PCS and its overlap Fibromyalgia Syndrome (FMS). We enrolled assessed the nature associated symptoms using C19-YRS (Yorkshire Rehabilitation Scale). The FMS assessment was conducted as part standard clinical examination American College Rheumatology (ACR) 2010 criteria: (1) Widespread Pain Index (WPI) ≥ 7 severity (SS) score 5, or WPI between 3 6 SS 9, (2) consistent for at least months, (3) no alternative diagnosis. Of eighteen (average age 49.6 (SD 11.8) years; BMI 31.7 8.6)), twelve were female. average duration 27.9 6.97) post-infection. Thirteen (72.2%) met criteria, an 8.8 8.2, indicating high level significant quality life impacts. These findings support hypothesis that may develop long-term sequela viral infection, underscoring need further research into post-viral conditions.

Язык: Английский

Процитировано

2
The Interplay of Microbiota, Long COVID, and Musculoskeletal Pain: A Narrative Review DOI Creative Commons
Leila Simorgh, Rozita Hedayati,

Mina Sadat Mirshoja

и другие.

Deleted Journal, Год журнала: 2024, Номер 1(2)

Опубликована: Сен. 1, 2024

Context: Long COVID, a condition that persists after the acute phase of COVID-19, poses significant burden, with 10 - 45% recovered patients experiencing persistent symptoms. Among these, approximately 46% report musculoskeletal pain. This narrative review explores potential connections between gut microbiota, and pain, aiming to introduce new therapeutic avenues preventive strategies for managing symptoms in COVID patients. Evidence Acquisition: A comprehensive search was conducted using Google Scholar, Lens.org, ConnectedPaper.com identify relevant articles published 2019 2024. Keywords related pain were used. Articles selected based on predefined inclusion exclusion criteria, their quality assessed. Data from synthesized provide an overview interplay Results: Recent research highlights role microbiota modulating immune responses systemic inflammation. Dysbiosis has been linked severity progression COVID-19 persistence Individuals often experience new-onset manifestations, such as joint myalgia, chronic Additionally, dysbiosis associated conditions like lower back knee osteoarthritis. suggests relationship problems general may also extend patients, indicating broader implications outcomes. Therapeutic targeting probiotics, prebiotics, dietary interventions, have shown promise these improving overall health Conclusions: The evidence underscores importance understanding microbiota-musculoskeletal nexus COVID. Gut contributes inflammation, exacerbating associations other emphasize need microbiota-targeted strategies. Future should focus elucidating mechanisms linking exploring gut-brain axis, developing personalized approaches modulate microbiota. Advancing our this can pave way innovative address complex challenges posed by conditions.

Язык: Английский

Процитировано

0