Optical brain pulse monitoring of microvascular blood flow during endovascular treatment for acute ischemic stroke

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Abstract Background Endovascular treatment (EVT) of large vessel occlusion (LVO) strokes improves patient outcomes. However, significant challenges remain including detection microvascular no reflow phenomena, emboli to new territories and improving neuro-prognostication. Real time monitoring the brain microcirculation could assist in addressing these challenges. This first-in-human cohort study evaluated Optical Brain Pulse Monitoring (OBPM) blood flow during EVT. Methods OBPM is a non-invasive device using red infrared light capture pulse waveforms, reflecting relative arteriole venous pressure levels driving flow. classes – Arterial, Hybrid, Venous I, II Monotonous represent continuum states from normal (Arterial) critically low (Monotonous). sensors were positioned bilaterally over middle cerebral artery LVO stroke patients undergoing Data on demographics, imaging clinical outcomes collected. Results Eleven (mean age 71, NIHSS 13) enrolled. The most common class at presentation was I (64%). associated with hypoperfused tissue volume (p = 0.005). following EVT long-term outcomes, length hospital stay 0.04), modified Rankin Score 0.06) death 0.02). In one patient, detected an embolization territory that occurred internal carotid stenting. Conclusion waveforms demonstrated circulation features presenting stroke. These also such as size presentation, LOS mortality. improve intra-procedural evaluation reflow, complications has potential simple method for earlier detection. Clinical trial registration URL: https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=384769&isReview=true ; Unique identifier: ACTRN12622001320741

Язык: Английский

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A Point-of-Care Noninvasive Technique for Surrogate ICP Waveforms Application in Neurocritical Care

Neurocritical Care, Год журнала: 2023, Номер 40(1), С. 170 - 176

Опубликована: Июль 12, 2023

Язык: Английский

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Evaluating the effectiveness of non-invasive intracranial pressure monitoring via near-infrared photoplethysmography using classical machine learning methods

Biomedical Signal Processing and Control, Год журнала: 2024, Номер 96, С. 106517 - 106517

Опубликована: Июнь 14, 2024

Язык: Английский

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An ultrasensitive multimodal intracranial pressure biotelemetric system enabled by exceptional point and iontronics

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Ноя. 5, 2024

The accurate monitoring of vital physiological parameters, exemplified by heart rate, respiratory and intracranial pressure (ICP), is paramount importance, particularly for managing severe cranial injuries. Despite the rapid development implantable ICP sensing systems over past decades, they still suffer from, example, wire connection, low sensitivity, poor resolution, inability to monitor multiple variables simultaneously. Here, we propose an ultrasensitive multimodal biotelemetric system that amalgamates iontronic transducer with exceptional point (EP) operation signals. proposed can exhibit extraordinary performance regarding detection minuscule fluctuation, demonstrated sensitivity 115.95 kHz/mmHg resolution down 0.003 mmHg. Our excels not only in quantification levels but also distinguishing respiration cardiac activities from signals, thereby achieving ICP, respiratory, rates within a single system. work may provide pragmatic avenue real-time wireless thus hold great potential be extended other indicators. parameters importance. authors rate.

Язык: Английский

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Cerebrovascular Responses in a Patient with Lundberg B Waves Following Subarachnoid Haemorrhage Assessed with a Novel Non-Invasive Brain Pulse Monitor: A Case Report

Medical Devices Evidence and Research, Год журнала: 2024, Номер Volume 17, С. 73 - 87

Опубликована: Фев. 1, 2024

Subarachnoid haemorrhage (SAH) can trigger a range of poorly understood cerebrovascular responses that may play role in delayed cerebral ischemia.The brain pulse monitor is novel non-invasive device detects photoplethysmography signal provides information on intracranial pressure (ICP), compliance, blood flow and tissue oxygen saturation.We monitored the patient with Lundberg B waves following SAH.The presented Fischer grade 4 SAH required urgent left posterior communicating artery aneurysm coiling ventricular drain insertion.On hospital day oscillations or spikes invasive ICP were noted, consistent waves.Brain monitoring demonstrated concurrent waveform features reduced compliance raised over both hemispheres.Oxygen levels also slow correlated spikes.Brief infrequent episodes absent pulses noted right hemisphere.Our findings suggest holds promise for early detection ischemia could offer insights into vascular mechanisms at play. Plain Language Summary:In this study, we examined serious bleed, known as subarachnoid hemorrhage (SAH).Patients suffer from vasospasm consequent (DCI), which happen to 14 days after initial bleeding.Detecting treating DCI difficult because methods are imperfect, discontinuous technically difficult.We used new, various health.This helps us understand inside skull, flow, saturation surface brain.In patient, found evidence of:• Brain signals directly related acute changes pressure.• Specific patterns indicate local reduction flow.• Signs breakdown brain's ability regulate injured hemisphere.• The changes.These results promising they new help identify when someone's condition getting worse.This guide development improved care protocols, aid clinical decision-making.Further research needed population additional forms generalizability our findings.

Язык: Английский

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Earlier Detection of Brain Injury Using Optical Brain Pulse Monitoring in Critically Ill Patients Following Cardiac Arrest

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract IMPORTANCE Point-of-care, non-invasive brain monitoring in critically ill patients following cardiac arrest could provide earlier detection of neurological injury and, when combined with treatments, limit injury. Point-of-care also enable better neuro-prognostication. OBJECTIVES The study assessed the time to using optical pulse (OBPM) compared routine monitoring. association OBPM signals more severe forms was assessed. DESIGN Retrospective analysis enrolled an observational study. SETTING Critical care unit a tertiary academic hospital. PARTICIPANTS Adult requiring mechanical ventilation critical arrest. MAIN OUTCOMES AND MEASURES uses red and infrared light capture waveforms whose morphology reflects relative arteriole venous pressure levels driving microvascular blood flow brain. sensors were placed bilaterally on anterior temporal region scalp, over middle cerebral artery territories. Time defined as period from first by or RESULTS Twelve enrolled, three required veno-arterial extra-corporeal membrane oxygenator support. In-hospital mortality 83% eight developed global hypoxic-ischemic median 57 hours (P < 0.01). In injured morphologies changed often different between hemispheres, high amplitude respiratory waves present. Known poor prognostic waveform present some CONCLUSIONS RELEVANCE detected Earlier improve patient outcomes through treatment KEY POINTS Question Can point-of-care monitoring? Findings this 12 Meaning

Язык: Английский

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Prospective comparative clinical trials of novel non-invasive intracranial pressure pulse wave monitoring technologies: preliminary clinical data

Interface Focus, Год журнала: 2024, Номер 14(6)

Опубликована: Дек. 6, 2024

Intracranial pressure (ICP) monitoring is crucial in the management of traumatic brain injury (TBI) and other neurological conditions. Elevated ICP or too low intracranial compliance (ICC) can compromise perfusion. Simultaneous ICC needed to optimize patient-specific perfusion pathological Surrogate changes be extracted by analysis pulse wave morphology. Non-invasive, fully passive sensor are needed. This study introduces Archimedes, a novel, passive, non-invasive monitor that utilizes mechanical pulsatile movement eyeball assess waveforms. Preliminary findings indicate high correlation r = [0.919; 0.96] between invasive morphologies, demonstrating device’s potential for accurate waveform monitoring. Additionally, discern changes, providing valuable insights TBI normal tension glaucoma patients according shape measured wave. The k-nearest neighbours algorithm used preliminary studies yielded promising diagnostic performance, with an accuracy 0.89, sensitivity 0.82, specificity 1.0 area under curve 0.91. Ethical approvals ongoing have been secured. Initial results Archimedes real-time safe, cost-effective alternative conventional techniques.

Язык: Английский

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The Development of Non-Invasive Optical Brain Pulse Monitoring: A Review

Medical Devices Evidence and Research, Год журнала: 2024, Номер Volume 17, С. 491 - 511

Опубликована: Дек. 1, 2024

Abstract: Early detection of neurological deterioration in serious acute brain injury is seen as an important goal to reduce death and disability, but monitoring for remains challenging. Routine methods, such examination imaging, often identify injuries only after they have progressed irreversible stage. Alternate approaches invasive monitoring, are complex, costly carry inherent risks. The optical pulse monitor (OBPM) a novel, non-invasive, safe, continuous device designed provide earlier address the limitations traditional approaches. This review presents development, technical aspects, clinical results from past ongoing trials over last five years. Keywords: monitor, injury, oxygen, cerebral blood flow, critical care, stroke

Язык: Английский

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Microwave Technique Based Noninvasive Monitoring of Intracranial Pressure Using Realistic Phantom Models

Communications in computer and information science, Год журнала: 2024, Номер unknown, С. 413 - 425

Опубликована: Янв. 1, 2024

Abstract Microwave technology is emerging as a promising candidate in the field of medical diagnosis and imaging has paved way for transition from invasive to non-invasive methods monitoring various biological phenomena inside human body. Intracranial Pressure (ICP) considered be very important parameter by practitioners assessing health subject. Accurate, prolonged, noninvasive measurement ICP still an open area research with no clinical success so far. Therefore, this paper, microwave-based method proposed. The setup utilizes flexible, thin, small, lightweight planner antennas that are suitable skin without compromising comfort proposed microwave tested on realistic head phantom model which imitates functioning hydrodynamics real head. results verified using pressure sensors. It deduced numerous trials system can detect small changes its response analogous actual values measured

Язык: Английский

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Are Intracranial Pressure Waveforms the New Frontier for Noninvasive Assessment of Intracranial Pressure?

Neurocritical Care, Год журнала: 2023, Номер 40(1), С. 48 - 50

Опубликована: Июль 12, 2023

Язык: Английский

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