Predictors of early neurological deterioration in patients with intracerebral hemorrhage: a systematic review and meta-analysis

Journal of Neurology, Год журнала: 2024, Номер 271(6), С. 2980 - 2991

Опубликована: Март 20, 2024

Язык: Английский

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Evaluation of Prognostic Implication of Serum Mixed Lineage Kinase Domain‐Like Protein in Acute Primary Supratentorial Intracerebral Hemorrhage: A Multicenter Prospective Cohort Study

Brain and Behavior, Год журнала: 2025, Номер 15(3)

Опубликована: Март 1, 2025

Abstract Objective Mixed lineage kinase domain‐like protein (MLKL) is a key component of necroptosis. Here, serum MLKL levels were measured with the intent to assess its prognostic significance in acute intracerebral hemorrhage (ICH). Methods A collective 161 patients primary supratentorial ICH and 73 controls enlisted this multicenter prospective cohort study. Serum at admission all patients, study entry controls, on post‐ICH days 1, 3, 5, 7, 10, 15 patients. Multivariate analyses adopted relationships between levels, severity, early neurological deterioration (END), poststroke 6‐month modified Rankin Scale (mRS) scores, poor prognosis (mRS scores 3–6). Results Patients, relative had significantly promoted from until Day 15, peaking value 3 ( p < 0.001). Admission independently correlated National Institutes Health Stroke (NIHSS) (beta, 0.133; 95% confidence interval (CI), 0.088–0.178; = 0.011), hematoma volume 0.051; 95%CI, 0.037–0.064; 0.001), mRS 0.707; 0.487–0.927; 0.023), as well predicted END (odds ratio, 1.902; 1.229–2.945; 0.014) 2.286; 1.324–3.946; 0.038). linearly connected risks > 0.05) 0.05), no interactions age, gender, hypertension, so forth (all possessed similar areas under receiver operating characteristic curve NIHSS 0.05). The models integrating graphically represented by nomogram good consistency calibration curve. Conclusions are markedly increased shortly following ICH, may accurately mirror disease efficaciously anticipate six‐month bad strengthening biomarker prospect ICH.

Язык: Английский

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Lentiviral Injection of Inter-α-Trypsin Inhibitor Heavy Chain 4 Promotes Female Spinal Cord Injury Mice Recuperation by Diminishing Peripheral and Central Inflammation

Inflammation, Год журнала: 2024, Номер unknown

Опубликована: Дек. 9, 2024

Язык: Английский

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