A new perspective on the regulation of neuroinflammation in intracerebral hemorrhage: mechanisms of NLRP3 inflammasome activation and therapeutic strategies
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 27, 2025
Intracerebral
hemorrhage
(ICH),
a
specific
subtype
within
the
spectrum
of
stroke
disorders,
is
characterized
by
its
high
mortality
and
significant
risk
long-term
disability.
The
initiation
progression
neuroinflammation
play
central
critical
role
in
pathophysiology
ICH.
NOD-like
receptor
family
pyrin
domain-containing
3
(NLRP3)
inflammasome,
protein
complex
involved
initiating
inflammation,
focus
this
article.
Microglia
astrocytes
roles
inflammatory
damage
process
associated
with
neuroinflammation.
NLRP3
inflammasome
expressed
both
types
glial
cells,
activation
drives
these
cells
toward
pro-inflammatory
phenotype,
which
exacerbates
brain.
However,
regulatory
relationship
between
two
cell
remains
to
be
explored.
Targeting
inflammasomes
microglia
or
may
provide
an
effective
approach
mitigate
following
This
article
first
provides
overview
composition
mechanisms
inflammasome.
Subsequently,
it
summarizes
recent
research
findings
on
novel
signaling
pathways
that
regulate
activity.
Finally,
we
reviewed
progress
inhibitors,
highlighting
clinical
translation
potential
certain
candidates.
These
inhibitors
hold
promise
as
innovative
strategies
for
managing
inflammation
Язык: Английский
A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage
Brain Hemorrhages,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Active Cryptococcus neoformans glucuronoxylomannan production prevents elimination of cryptococcal CNS infection in vivo
Vanessa Enriquez,
Melissa E. Munzen,
Luz M. Porras
и другие.
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Март 4, 2025
Cryptococcus
neoformans
(Cn)
causes
life-threatening
meningoencephalitis
in
individuals
with
AIDS.
Cn's
polysaccharide
capsule
is
mainly
composed
of
glucuronoxylomannan
(GXM)
and
plays
a
key
role
the
dysregulation
immunity,
resistance
to
antifungal
drugs,
systemic
dissemination,
including
CNS
invasion.
Although
recent
studies
have
begun
elucidate
involvement
microglia
cryptococcosis,
our
knowledge
these
resident
phagocytes
control
cryptococcosis
limited.
We
investigated
microglial
responses
Cn
infection
effect
active
capsular
production
by
comparing
wild-type
H99
acapsular
mutant
cap59
strains
using
CX3CR1-EGFP
transgenic
mouse
stereotaxic
intracerebral
model.
Microglia
had
difficulty
combating
infection.
Active
secretion
material
altered
morphology
distribution
around
cryptococcomas
or
fungal
brain
lesions.
It
also
affected
infiltration
peripheral
immune
cells
Moreover,
RNA
sequencing
analyses
supported
importance
modulation.
Chemotaxis
assays
demonstrated
that
H99,
especially
GXM,
impaired
motility
phagocytosis.
Our
findings
suggest
may
not
be
able
cryptococcal
release
contribute
progression
persistence
cerebral
cryptococcosis.
Язык: Английский
Exploring the correlation between innate immune activation of inflammasome and regulation of pyroptosis after intracerebral hemorrhage: From mechanism to treatment
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117382 - 117382
Опубликована: Сен. 6, 2024
Язык: Английский