Future Science OA, Год журнала: 2024, Номер 10(1)
Опубликована: Ноя. 14, 2024
Aim: Early biomarkers of phenoconversion to neurodegeneration are crucial identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4+ T cells exhibit a peculiar transcription pattern.
Язык: Английский
The Lancet Neurology, Год журнала: 2024, Номер 23(9), С. 925 - 937
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
12
GeroScience, Год журнала: 2025, Номер unknown
Опубликована: Янв. 8, 2025
Язык: Английский
Процитировано
0
Nature Reviews Neurology, Год журнала: 2025, Номер unknown
Опубликована: Май 12, 2025
Язык: Английский
Процитировано
0
Frontiers in Neurology, Год журнала: 2025, Номер 16
Опубликована: Июнь 4, 2025
Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and it has an unclear pathogenesis lacks validated, specific biomarker-based diagnostic approaches, particularly in PD patients with rapid eye movement (REM) sleep behavior disorder (PD-RBD). Methods Using untargeted liquid chromatography-mass spectrometry (LC–MS) metabolomics, serum profiles of 41 drug-naïve [including 19 PD-RBD 22 without RBD (PD-nRBD) patients] 20 healthy controls (HCs) were analyzed. Results Comparative analyses revealed 144 dysregulated metabolites versus HCs, 7 metabolites—sodium deoxycholate, S-adenosylmethionine, L-tyrosine, 3-methyl-L-tyrosine, 4,5-dihydroorotic acid, (6Z)-octadecenoic allantoin—demonstrating high classification accuracy [area under curve (AUC) > 0.93]. Compared PD-nPBD patients, exhibited distinct metabolic profiles, characterized by 21 differentially expressed metabolites, including suberic methyl (indol-3-yl) acetate (AUC 0.86). Notably, 3-methyl-L-tyrosine displayed dual dynamics, reflecting dopaminergic depletion compensatory adaptations PD-RBD. Pathway enrichment analysis implicated central carbon metabolism (CCM) disruption peroxisome proliferator-activated receptor (PPAR) signaling pathway inactivation Conclusion These findings reveal potential serum-based biomarkers for PD-RBD, highlight CCM PPAR pathways as therapeutic targets, underscore role dysregulation pathophysiology.
Язык: Английский
Процитировано
0
Brain and Behavior, Год журнала: 2024, Номер 14(3)
Опубликована: Март 1, 2024
Abstract Rapid eye movement behavior disorder (RBD) is a parasomnia characterized by the loss of skeletal muscle atonia during rapid (REM) sleep phase. On other hand, idiopathic RDB (iRBD) considered prelude various α‐synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. Consequently, over 40% patients eventually develop PD. Recent neuroimaging studies utilizing structural magnetic resonance imaging (s‐MRI), diffusion‐weighted (DWI), functional (fMRI) graph theoretical analysis have demonstrated that iRBD extensive brain abnormalities. Thus, it crucial to identify new biomarkers aid in determining underlying physiopathology group. This review was conducted systematically on included full‐text articles s‐MRI, DWI, fMRI using iRBD, per procedures recommended Preferred Reporting Items for Systematic Reviews Meta‐Analyses (PRISMA). The literature search through PubMed Google scholar databases concentrating from September January 2022. Based three perspectives integration, segregation, centrality, reviewed associated segregation disorders frontal limbic regions. Moreover, this study highlighted need additional longitudinal multicenter better understand potential metrics as identifying
Язык: Английский
Процитировано
3
Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102373 - 102373
Опубликована: Июль 2, 2024
Язык: Английский
Процитировано
2
IEEE Open Journal of Engineering in Medicine and Biology, Год журнала: 2024, Номер 5, С. 859 - 866
Опубликована: Янв. 1, 2024
Goal: REM Sleep Behavior Disorder (RBD) is a parasomnia that associated to high risk of developing ⍺-synucleinopathies, as Parkinson's disease (PD) or dementia with Lewy bodies, over time. This study aims at investigating the presence autonomic dysfunctions in RBD subjects, and without PD, by assessing their sleep structure autonomous nervous system activity along different stages. Methods: To this aim, an innovative framework combining transition model, Markov chains, instantaneous assessment state dynamics statistical modeling heart rate variability (HRV) through point-process approach, was introduced. Results: In general, groups showed lower HRV than controls across all stages, well higher probabilities transitioning towards lighter Subjects also affected PD present even HRV, but better continuity. Conclusions: patients suffer from fragmentation overall dysfunction, mainly due activation Coexistence seems improve quality, possibly sleep-related relief symptoms.
Язык: Английский
Процитировано
1
Movement Disorders Clinical Practice, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 7, 2024
Patients with Parkinson's Disease (PD) frequently exhibit non-motor symptoms, particularly sleep disturbances. Sleep disorders in PD patients are intricately linked to the pathogenesis and progression of itself, exacerbating neurodegenerative processes worsening patient quality life.
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 388 - 404
Опубликована: Окт. 4, 2023
Язык: Английский
Процитировано
2
Journal of Clinical Medicine, Год журнала: 2023, Номер 12(16), С. 5271 - 5271
Опубликована: Авг. 13, 2023
Healthy sleep is indissolubly linked to both physical and mental health, as pointed out by evidence showing the negative impact of poor on neurological, psychiatric, cardiovascular, respiratory, metabolic, immune systems, among others [...].
Язык: Английский
Процитировано
1