TFAP2A facilitates the metastasis and radioresistance of esophageal cancer by promoting EGFR transcription

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Язык: Английский

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Exploring the genetic link between gastroesophageal reflux disease and pancreatic cancer: insights from Mendelian randomization

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Апрель 18, 2025

Gastroesophageal reflux disease (GERD) is increasingly recognized for its associations with extragastric diseases, yet potential role in pancreatic cancer (PC) etiology remains underexplored. This study investigates the genetic causal relationship between GERD and PC using Mendelian randomization (MR), a method designed to reduce confounding factors. A two-sample MR analysis was conducted genome-wide association studies (GWAS) data. The inverse variance weighted (IVW) applied, additional sensitivity analyses performed evaluate pleiotropy heterogeneity. IVW demonstrated significant signature predisposing an increased risk of (OR: 1.36, 95% CI: 1.04-1.80, P = 0.03). There no evidence (P 0.71) or heterogeneity 0.94). Our provides robust supporting that predisposition associated PC. These findings emphasize necessity integrating into assessments encourage further research elucidate underlying biological mechanisms. insight holds inform strategies early detection, prevention, personalized management patients.

Язык: Английский

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The roles of exosomes in esophageal cancer

Discover Oncology, Год журнала: 2024, Номер 15(1)

Опубликована: Авг. 27, 2024

The incidence and mortality rate of esophageal cancer (EC) are higher worldwide. Exosomes nanoscale vesicles derived from various types cells, exhibiting a stable presence in bodily fluids, contain plethora bioactive components including proteins, DNA, RNA. can mediate cell-to-cell communication signaling. Numerous studies conducted both domestically internationally have indicated the significant involvement exosomes tumor development their potential as novel diagnostic prognostic biomarkers for liquid biopsy. This review seeks to consolidate role substances progression EC elaborate on opportunities challenges associated with clinical application EC.

Язык: Английский

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Extracellular Vesicles and Their Applications in Tumor Diagnostics and Immunotherapy

Cells, Год журнала: 2024, Номер 13(23), С. 2031 - 2031

Опубликована: Дек. 9, 2024

Extracellular vesicles (EVs) are cell-derived nanoparticles that have attracted significant attention in the investigation of human health and disease, including cancer biology its clinical management. Concerning cancer, EVs been shown to influence numerous aspects oncogenesis, tumor proliferation metastasis. can augment immune system implicated virtually all innate adaptive immunity. With immunotherapy changing landscape treatment across multiple disease sites, it is paramount understand their mechanisms action further improve upon efficacy. Despite a rapidly growing body evidence supporting utility diagnostics therapeutics, application trials involving solid tumors remains limited. To date, relatively few known incorporate this context, mainly employing them as biomarkers. help address gap, review summarizes applications provides brief overview roles play biology, immunology, proposed implications immunotherapy. The impetus leverage future correlative studies crucial, they ideally positioned synergize with advancements multi-omics research therapeutic discovery our understanding biology.

Язык: Английский

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QSOX1 exerts anti-inflammatory effects in sepsis-induced acute lung injury: regulation involving EGFR phosphorylation mediated M1 polarization of macrophages

The International Journal of Biochemistry & Cell Biology, Год журнала: 2024, Номер 176, С. 106651 - 106651

Опубликована: Сен. 7, 2024

Язык: Английский

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