Harnessing Pyroptosis for Lung Cancer Therapy: The Impact of NLRP3 Inflammasome Activation
Pathology - Research and Practice,
Год журнала:
2024,
Номер
260, С. 155444 - 155444
Опубликована: Авг. 1, 2024
Язык: Английский
Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
175, С. 116667 - 116667
Опубликована: Май 3, 2024
Regulated
cell
death
(RCD)
is
a
form
of
that
can
be
regulated
by
numerous
biomacromolecules.
Accumulating
evidence
suggests
dysregulated
expression
and
altered
localization
related
proteins
in
RCD
promote
the
development
cancer.
Targeting
subroutines
with
pharmacological
small-molecule
compounds
becoming
promising
therapeutic
avenue
for
anti-tumor
treatment,
especially
hematological
malignancies.
Herein,
we
summarize
aberrant
mechanisms
apoptosis,
necroptosis,
pyroptosis,
PANoptosis,
ferroptosis
In
particular,
focus
on
relationship
between
tumorigenesis,
immunotherapy,
drug
resistance
Furthermore,
discuss
emerging
strategies
targeting
different
subroutines.
This
review
aims
to
significance
potential
malignancies,
along
utilization
pertinent
strategies.
Язык: Английский
Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3‑dependent pyroptosis in non‑small cell lung cancer cells
International Journal of Oncology,
Год журнала:
2025,
Номер
66(3)
Опубликована: Фев. 13, 2025
Non‑small
cell
lung
cancer
(NSCLC)
is
a
malignant
tumor
of
significant
clinical
relevance.
Curcumin
has
been
investigated
for
its
potential
anticancer
properties,
as
it
reported
to
act
through
multiple
cancer‑related
targets
and
pathways.
The
present
study
aimed
explore
the
effects
curcumin
in
NSCLC
using
both
vitro
vivo
models.
lines
(specifically,
A549
NCI‑H1299
cells),
mouse
model
established
subcutaneous
injection
cells,
were
utilized
evaluate
intervention.
treatment
with
on
NOD‑like
receptor
pyrin
domain‑containing
3
(NLRP3)
ubiquitination,
pyroptosis
pyroptosis‑associated
factors
also
evaluated.
In
addition,
Smad
ubiquitination
regulatory
factor
2
(Smurf2)
was
analyzed
via
series
knockdown
overexpression
experiments,
vivo,
at
investigating
association
NLRP3.
results
obtained
from
these
experiments
showed
that
inhibited
growth,
promoted
reduced
level
NLRP3
ubiquitination.
reversed
curcumin‑induced
increase
vivo.
Additionally,
Smurf2
interacted
alterations
expression
levels
influenced
pyroptosis.
Moreover,
molecular
docking
analysis
demonstrated
could
bind
directly
Smurf2,
which
subsequently
led
an
inhibition
activity.
Knockdown
enhanced
curcumin's
ability
stabilize
promote
pyroptosis,
whereas
negated
effects.
animal
model,
volumes
weights,
addition
decreased
Ki67
increased
factors.
Similarly,
or
by
overexpression,
respectively.
conclusion,
findings
activity,
thereby
promoting
NLRP3‑dependent
cells.
have
provided
mechanistic
insights
into
role
NSCLC,
opening
avenue
therapeutic
application.
Язык: Английский
Identification of key genes and biological pathways in chronic obstructive pulmonary disease using bioinformatics and next generation sequencing data analysis
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 14, 2024
Abstract
Identification
of
accurate
biomarkers
is
still
particularly
urgent
for
improving
the
poor
survival
chronic
obstructive
pulmonary
disease
(COPD)
patients.
In
this
investigation,
we
aimed
to
identity
potential
in
COPD
via
bioinformatics
and
next
generation
sequencing
(NGS)
data
analysis.
differentially
expressed
genes
(DEGs)
were
identified
using
NGS
dataset
(GSE239897)
from
Gene
Expression
Omnibus
(GEO)
database.
Subsequently,
gene
ontology
(GO)
pathway
enrichment
analysis
was
conducted
evaluate
underlying
molecular
mechanisms
involved
progression
COPD.
Protein-protein
interaction
(PPI),
modules,
miRNA-hub
regulatory
network
TF-hub
performed
determine
hub
genes,
miRNAs
TFs.
The
receiver
operating
characteristic
(ROC)
diagnostic
value
genes.
A
total
956
overlapping
DEGs
(478
up
regulated
478
down
genes)
dataset.
mainly
associated
with
GO
functional
terms
pathways
cellular
response
stimulus.
stimulus,
immune
system
neutrophil
degranulation.
There
10
(MYC,
LMNA,
VCAM1,
MAPK6,
DDX3X,
SHMT2,
PHGDH,
S100A9,
FKBP5
RPS6KA2)
by
PPI,
conclusion,
DEGs,
relative
terms,
present
investigation
might
aid
understanding
provide
targets
Язык: Английский
Pyroptosis and chemical classification of pyroptotic agents
Molecular Diversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 24, 2024
Abstract
Pyroptosis,
as
a
lytic-inflammatory
type
of
programmed
cell
death,
has
garnered
considerable
attention
due
to
its
role
in
cancer
chemotherapy
and
many
inflammatory
diseases.
This
review
will
discuss
the
biochemical
classification
pyroptotic
inducers
according
their
chemical
structure,
mechanism,
these
targets.
A
structure-activity
relationship
study
on
is
revealed
based
surveyed
inducer
chemotherapeutics.
The
shared
features
structures
current
agents
were
displayed,
including
an
essential
cyclic
head,
vital
linker,
hydrophilic
tail
that
significant
for
π-π
interactions
hydrogen
bonding.
presented
structural
open
way
design
new
hybridized
classes
or
scaffolds
potent
future,
which
may
represent
solution
apoptotic-resistance
dilemma
along
with
synergistic
chemotherapeutic
advantage.
Graphical
Язык: Английский