Chronic fatigue syndrome, depression, and anxiety symptoms due to relapsing-remitting multiple sclerosis are associated with reactivation of Epstein-Barr virus and Human Herpesvirus 6. DOI Creative Commons
Michaël Maes, Abbas F. Almulla, Elroy Vojdani

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Relapsing-remitting multiple sclerosis (RRMS) is defined by elevated IgG/IgA/IgM responses targeting Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA) and deoxyuridine-triphosphatases (dUTPases) of Human herpsesvirus-6 (HHV-6) EBV. These suggest that the viruses are being replicated reactivated. An increased prevalence chronic fatigue syndrome, depression, anxiety associated with signs immune activation in RRMS. Nevertheless, there a lack data regarding association between viral reactivation neuropsychiatric symptoms This study investigated to EBNA, EBV HHV-6-dUTPases, 58 remitted RRMS patients 63 normal controls. The McDonald criteria were employed establish diagnosis MS. Expanded Disability Status Scale (EDSS) Multiple Sclerosis Severity Score evaluate disabilities caused We evaluated scores Hamilton Depression (HAMD) Anxiety (HAMA) Rating Scales, Fibro-Fatigue (FF) scale. One latent construct was extracted from EDSS, MSSS, FF, HAMD, HAMA scores. discovered combined effects IgG IgM-HHV-6-dUTPAses accounted for 63.7% variance this construct. Furthermore, total HAMA, HAMD substantially IgM-HHV-6-dUTPAses, accounting approximately 38.7% 51.0% variance. three rating scale also significantly correlated IgA reactivity directed both dUTPases EBNA. In conclusion, replication HHV-6 contributes as well depression due

Язык: Английский

Chronic fatigue syndrome, depression, and anxiety symptoms due to relapsing-remitting multiple sclerosis are associated with reactivation of Epstein-Barr virus and Human Herpesvirus 6. DOI Creative Commons
Michaël Maes, Abbas F. Almulla, Elroy Vojdani

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 14, 2024

Abstract Relapsing-remitting multiple sclerosis (RRMS) is defined by elevated IgG/IgA/IgM responses targeting Epstein-Barr Virus (EBV) nuclear antigen 1 (EBNA) and deoxyuridine-triphosphatases (dUTPases) of Human herpsesvirus-6 (HHV-6) EBV. These suggest that the viruses are being replicated reactivated. An increased prevalence chronic fatigue syndrome, depression, anxiety associated with signs immune activation in RRMS. Nevertheless, there a lack data regarding association between viral reactivation neuropsychiatric symptoms This study investigated to EBNA, EBV HHV-6-dUTPases, 58 remitted RRMS patients 63 normal controls. The McDonald criteria were employed establish diagnosis MS. Expanded Disability Status Scale (EDSS) Multiple Sclerosis Severity Score evaluate disabilities caused We evaluated scores Hamilton Depression (HAMD) Anxiety (HAMA) Rating Scales, Fibro-Fatigue (FF) scale. One latent construct was extracted from EDSS, MSSS, FF, HAMD, HAMA scores. discovered combined effects IgG IgM-HHV-6-dUTPAses accounted for 63.7% variance this construct. Furthermore, total HAMA, HAMD substantially IgM-HHV-6-dUTPAses, accounting approximately 38.7% 51.0% variance. three rating scale also significantly correlated IgA reactivity directed both dUTPases EBNA. In conclusion, replication HHV-6 contributes as well depression due

Язык: Английский

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