
European Eating Disorders Review, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
ABSTRACT The human brain possesses a unique ability to switch between patterns of functional connectivity, known as states, which are crucial for regulating biological, cognitive, and emotional processes. These states linked numerous neurological neuropsychiatric conditions, however, their relationship clinical symptoms anorexia nervosa (AN) is not well understood. In this exploratory study, we aimed identify whole‐brain dynamic alterations in AN association with symptoms. To end, recruited 19 women diagnosed 22 healthy controls (HCs) who underwent resting‐state magnetic resonance imaging. By implementing sliding‐window approach, found that patients had limited flexibility transit different configurations compared HCs. Moreover, spent significant amount time configuration characterised by strong coupling the ventral attentional network somatomotor network. Changes these networks play role body image disturbances, interoceptive awareness, image‐body schema interaction. Interestingly, specific state showed negative mass index, along positive correlation eating disorder indices. Our study highlights potential connectivity prognostic therapeutic means spotlight maladaptive AN.
Язык: Английский