The effect of targeted therapy on the quality of life of patients with polypous rhinosinusitis and comorbid bronchial asthma

Meditsinskiy sovet = Medical Council, Год журнала: 2024, Номер 9, С. 38 - 46

Опубликована: Июнь 6, 2024

Introduction . The relevance of studying the possibility using targeted therapy in treatment polypous rhinosinusitis patients with comorbid bronchial asthma is due to observed growth disease and disclosure new pathophysiological mechanisms their development. Aim Based on generalization research results analysis our own clinical observations, improve effectiveness quality life a history severe asthma, genetically engineered biological therapy. Materials methods literature eLibrary databases analyzed.RU RSCI, Medline, Scopus, Web Science for period 2011–2023. inclusion monoclonal antibodies regimen diseases that are difficult treat medication based studies meta-analysis data. A study was conducted, according SF-36 Health Status Survey, 47 receiving medical preventive institutions megalopolis. Results assessment confirmed antibodies. According SP-36 questionnaire, before treatment, low-est scores were Role-Physical Functioning scales – 51.5 points General 49.1 points, respectively. At 2 nd 16 th weeks gradually increasing positive dynamics noted all by end 52 week antibody use, values as close normal possible recorded Social Functioning, Role Emotional, Mental amounted 97.7; 98,3 98.7 points. two cases. Conclusions Knowledge immunological pathogenetic allows us open up significant prospects diagnosis treatment. Recommendations drug selection should be consistently followed within framework recommendations relevant diseases. Strict consideration development short-term long-term risks use necessary.

Язык: Английский

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The effectiveness of a polyvalent antigenic complex including bacterial lysates in the treatment and prevention of rhinosinusitis against the background of acute respiratory viral infections and COVID-19 (clinical description)

Meditsinskiy sovet = Medical Council, Год журнала: 2023, Номер 7, С. 52 - 62

Опубликована: Май 5, 2023

One of the urgent tasks Ministry Health Russian Federation, noted in State report on state sanitary and epidemiological welfare population, is improvement implementation diagnostic treatment prevention technologies. First all, this concerns continued growth respiratory viral infections, seasonal influenza epidemics, where SARS-CoV-2 coronavirus infection occupies a special place, which often cause various otorhinolaryngological complications – acute exacerbations chronic tonsillopharyngitis, rhinosinusitis, tubotitis, purulent otitis media. In bacterial sinusitis, accordance with clinical recommendations, intranasal corticosteroids, elimination therapy, herbal remedies, antibacterial drugs are used. Due to period pandemic, significant proportion patients took large doses drugs, caused an increase resistance microorganisms them. regard, it possible use immunostimulating that stimulate cellular humoral immunity, promote development specific immune response activate nonspecific defense factors such as lysozyme, mucin, lactoferrin normalize mucociliary clearance. As rule, identification agent carried out case severe course disease or from ORL other organs, agents complex therapy necessary at earliest time disease. context, immunostimulants containing polyvalent antigenic complexes, including lysates, most common pathogens justified. It preferable these cases lysates bacteria obtained by mechanical destruction cells, since they have more pronounced non-specific immunostimulatory vaccinating effect.

Язык: Английский

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Pharmacotherapeutic efficacy of the use of pelargonium sidovid root extract in the prevention and treatment of respiratory diseases

Meditsinskiy sovet = Medical Council, Год журнала: 2023, Номер 7, С. 63 - 71

Опубликована: Май 5, 2023

Relevance in research infectious and inflammatory diseases of the upper respiratory tract caused by high prevalence, variability clinical manifestations severity disease with risk developing complications. Respiratory are a cause functional morphological disorders mucosa which is protective barrier against various damaging agents. It necessary to use complex drugs that preserve restore physiological activity mucous membrane as much possible. In this regard, there great interest plant medical product (extract roots pelargonium sidovid chief active ingredient) causes stimulation nonspecific mechanisms, beating frequency cilia ciliated epithelium, NK cells, phagocytes, modulation synthesis interferon proinflammatory cytokines, expression adhesive molecules, chemotaxis. We can notice moderate direct antibacterial antiviral properties extract. The pharmacotherapeutic efficacy containing an extract was analysed our treatment diseases. There literature review about safety preparations liquid roots. effectiveness confirmed results investigation: children adults digest drug, greatly facilitates course diseases, prevents development complications, reduces duration acute infections. Extract easy dosage. All these make it possible include therapy tract.

Язык: Английский

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Phage therapy in overcoming antibiotic resistance in chronic rhinosinusitis

Russian Bulletin of Otorhinolaryngology, Год журнала: 2023, Номер 88(6), С. 48 - 48

Опубликована: Янв. 1, 2023

The relevance of the study is due to observed increase in antibiotic resistance main pathogens chronic rhinosinusitis.

Язык: Английский

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Therapeutic and diagnostic approaches in the treatment of chronic tonsillitis

Meditsinskiy sovet = Medical Council, Год журнала: 2022, Номер 20, С. 90 - 99

Опубликована: Ноя. 16, 2022

Introduction. The relevance of the treatment chronic tonsillitis is due to both high prevalence and severity course disease with variable development tonsillogenic complications, local general. Important aspects are not always effective results conservative methods treatment, including use antibacterial drugs and, as a result, decrease in quality life patients. Objective. Based on dynamics blood leukocyte indices signs tonsillitis, determine effectiveness using an antimicrobial agent plant origin patients various age groups. Materials methods. A prospective study was conducted 494 aged 8 58 years who were treated outpatient basis for more than two years. Depending form ongoing therapy, randomly divided into 4 subgroups. Results discussion. Evaluation groups carried out according formula. average values verified most patients, which manifested itself activation phagocytic process herbal preparation made it possible reduce manifestations systemic clinical symptoms tonsillitis. Conclusion. objective assessment analysis indices, inclusion shown.

Язык: Английский

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New treatment options for acute respiratory viral infections

Meditsinskiy sovet = Medical Council, Год журнала: 2022, Номер 20, С. 30 - 36

Опубликована: Ноя. 15, 2022

The treatment of acute respiratory viral infection remains an urgent public health problem. There are currently a limited number drugs used for the and prevention this pathology with proven efficacy safety. According to current views in field immunology, most important role immune protection against both viruses bacteria is played by molecules receptors that form so-called “immune synapse”, understood as contact cells involved detection antigen triggering subsequent chain reactions destroy it. A complex antiviral drug has ability modulate rather than block activity its target product containing technologically treated antibodies interferon gamma, CD4 domains main histocompatibility complex. combined action components helps reduce load on body, severity symptoms SARS during first days, duration infectious disease. pharmacological effect achieved acting key recognition pathogens bacterial origin system. In addition, direct IFN-γ, which results stopping multiplication protecting healthy from infection. use antibody-based reduces risk complications increase body’s resistance infections tract. clinical trials, shown high safety (ARI) adults. medicine paediatric COVID-19 outpatient setting being investigated multicentre, double-blind, placebo-controlled randomised trials.

Язык: Английский

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Adaptation of the hearing analyzer under vibration noise exposure in volunteers: Ways of prevention

Russian Medicine, Год журнала: 2023, Номер 29(2), С. 116 - 126

Опубликована: Апрель 28, 2023

BACKGROUND: The negative effect of impulse noise and vibration when using small arms on the auditory analyzer in athletes is less investigated justifies need for an extended study volunteers with normal hearing. initial characteristics effects sports weapons will make it possible to determine early risk factors occurrence high-frequency hearing loss shooters by number shots from recovery time function. AIMS: To conduct a comparative analysis exposure depending technical and, based results obtained, unify methods forecasting prevention. MATERIALS AND METHODS: At Department Otorhinolaryngology South Ural State Medical University Ministry Health Russia, 30 fifth-year students were examined following continuous recruitment between September 2022 November 2022. All interviewed participants gave voluntary written consent participate survey test level noise. Based current regulatory documents, all surveyed underwent audiological vestibulometric studies, as factor development presbycusis determined, ways preventing through lifestyle proposed. RESULTS: influence showed dependence weight cartridge, shots, adaptation considering changes spectrum increasing audiometry thresholds average value indicators. CONCLUSIONS: use active explanatory propaganda among young people careful attitude physiological state cochleovestibular apparatus avoids development.

Язык: Английский

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Medical and psychological reasons for getting aesthetic rhinoplasty

Meditsinskiy sovet = Medical Council, Год журнала: 2023, Номер 7, С. 196 - 202

Опубликована: Май 11, 2023

The original desire of all people is the to look more attractive by improving their appearance and most advanced direction, in achieving aesthetic superiority, cosmetic surgical interventions have been remain. leading place patient’s desires occupied facial surgery, where popular not always justified change shape external nose. To date, techniques for performing rhinoplasty reached perfection. But at stage selecting patients surgery on nose, doctors face certain difficulties. common problems plastic surgeons are created with dysmorphophobia where, example, main motive persons dysmorphomania make dissatisfaction size own which, opinion, prevents them from success personal life, building a career, etc. Other dysmorphophobic syndrome low self-esteem, ugly nose marriage In this context, an unsuccessful example patient whose anamnesis was aggravated polypous rhinosinusitis bronchial asthma uncontrolled course given. A brief review literature presented clinical examples substantiate need address number important questions stages selection planning rhinoplasty: does mental disorders; what true reasons motivating surgery; whether there any diseases upper respiratory tract, violations architectonics deep sections nasal cavity, preventing operations,

Язык: Английский

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Historical aspects of fungal sinusitis, topical issues of early diagnosis and medical care on clinical example: A review

Consilium Medicum, Год журнала: 2023, Номер 25(3), С. 179 - 186

Опубликована: Июнь 7, 2023

Inflammatory diseases of the nose and paranasal sinuses provoked by fungal contamination have been on rise over past decades. The cause infection, according to literature, is more often accidental ingestion filling material, fragments teeth small parts implant into sinuses, followed contamination. Diagnosis sinusitis, as a rule, not difficult, but if use modern technological capabilities research differential analysis refused or ignored, verification diagnosis may be erroneous routing patient will determined correctly. In context early timely treatment inflammatory course, brief historical overview reflecting importance existing problem useful for doctors, given clinical example largely help avoid mistakes.

Язык: Английский

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Immunological efficacy of cavitated solutions in the complex therapy of chronic rhinitis

Terapevt (General Physician), Год журнала: 2023, Номер 6, С. 5 - 9

Опубликована: Июнь 21, 2023

Quantitative and qualitative indicators of nasal lavages in patients with chronic rhinitis have been studied. The results the study shown that an increase number viable neutrophilic granulocytes their lysosomal activity, a decrease activity intensity phagocytosis, inhibition biocidal properties according to spontaneous HCT test, content secretory IgA are recorded rhinitis. use 0.9 % sodium chloride cavitated solution led restoration quantitative innate immunity some adaptive patients’ secretions.

Язык: Английский

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