A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease DOI Creative Commons
A.J. Mateo Orobia,

José Manuel Benítez del Castillo,

Margarita Calonge

и другие.

Acta Ophthalmologica, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder significantly impacts patients' quality of life, with prevalence rates ranging from 5% to 50% higher incidence in women. DED involves tear film instability, inflammation neurosensory abnormalities, making its management challenging due diverse underlying mechanisms. Conventional treatments typically focus on symptom relief, but new approaches targeting disease's pathogenesis are emerging. Alpha‐lipoic acid (ALA) gaining attention for potential treating OSD DED. ALA acts as potent antioxidant, neutralizing reactive oxygen species. It protects cell membranes by interacting vitamin C glutathione, potentially recycling E. Its antioxidative properties particularly relevant meibomian gland dysfunction, condition implicated By scavenging free radicals modulating redox status glands, can reduce oxidative damage, preserve glandular function decrease inflammation. In diabetic patients DED, administration has been found improve parameters, corneal defects, enhance antioxidant prevent retinopathy keratopathy. therapeutic effects especially polyneuropathy other neuropathies, primarily anti‐inflammatory metal‐chelating properties. summary, holds promise agent could be promising treatment option keratopathy, although further research needed confirm efficacy.

Язык: Английский

A narrative literature review about alpha‐lipoic acid role in dry eye and ocular surface disease DOI Creative Commons
A.J. Mateo Orobia,

José Manuel Benítez del Castillo,

Margarita Calonge

и другие.

Acta Ophthalmologica, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Abstract Ocular surface diseases (OSD) include various conditions that affect the eye's surface, causing discomfort and pain. One such condition, dry eye disease (DED), is a multifactorial disorder significantly impacts patients' quality of life, with prevalence rates ranging from 5% to 50% higher incidence in women. DED involves tear film instability, inflammation neurosensory abnormalities, making its management challenging due diverse underlying mechanisms. Conventional treatments typically focus on symptom relief, but new approaches targeting disease's pathogenesis are emerging. Alpha‐lipoic acid (ALA) gaining attention for potential treating OSD DED. ALA acts as potent antioxidant, neutralizing reactive oxygen species. It protects cell membranes by interacting vitamin C glutathione, potentially recycling E. Its antioxidative properties particularly relevant meibomian gland dysfunction, condition implicated By scavenging free radicals modulating redox status glands, can reduce oxidative damage, preserve glandular function decrease inflammation. In diabetic patients DED, administration has been found improve parameters, corneal defects, enhance antioxidant prevent retinopathy keratopathy. therapeutic effects especially polyneuropathy other neuropathies, primarily anti‐inflammatory metal‐chelating properties. summary, holds promise agent could be promising treatment option keratopathy, although further research needed confirm efficacy.

Язык: Английский

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