Protective effect of ginseng seed oil nanoemulsion against human coronavirus OC43 through modulation of ABCG transporters DOI Creative Commons

Sanjeevram Dhandapania,

Rongbo Wang, Abdus Samad

и другие.

Journal of Functional Foods, Год журнала: 2024, Номер 117, С. 106240 - 106240

Опубликована: Май 20, 2024

Recent studies have highlighted the potential of unsaturated fatty acids in natural oils to influence virus replication. This study extracted ginseng seed oil (GSO) and evaluated its physiochemical parameters, lipid class, oxidation stability. GSO was then synthesized into an oil/water nanoemulsion (NE) through optimized formulation, time, temperature, storage conditions. GSO-NE showed no cytotoxicity up 5 µg/mL but effectively inhibited HCoV-OC43 replication suppressed proinflammatory biomarkers infected cells. RNA sequencing revealed significant alterations gene expression profile by treatment, particularly implicating ABC transporters signaling pathway. Notably, downregulated ABCG subfamily membrane proteins, crucial for regulation virus-infected The downregulation these genes (ABCG1, ABCG2, ABCG4, ABCG5/8) reversed GSO-NE, as demonstrated qRT-PCR. Furthermore, ABCG1 ABCG5/8 confirmed using immunoblotting techniques. These findings suggest a promising avenue future research or therapeutic applications.

Язык: Английский

Effect of Chitosan/jojoba oil/ZnO nanocomposite Capsules Applications on Some Chemical Properties of Polluted Soils DOI Open Access

Doaa Eissa

Egyptian Journal of Soil Science, Год журнала: 2024, Номер 64(2), С. 673 - 698

Опубликована: Март 9, 2024

Using chitosan/jojoba oil and oil/ZnO nanocomposite capsules, this study looked at how to get rid of Fe2+ Ni2+ ions from soil in areas with high levels heavy metals like ions, which pose environmental risks the ecosystem. The created adsorbents were characterized using scanning electron microscopy (SEM), Fourier transform infrared (FTIR), particle size measurements transmission (TEM). A batch experiment was performed determine effects contact time, adsorbate concentration, temperature, solution pH. At pH 3.3 5.3, composite materials demonstrated adsorption efficiencies 90% for 69.8% aqueous solutions. According isotherm investigations, polymer nanocomposites satisfy Langmuir Freundlich models. But model more accurately experimental data. results suggested that capsules serve as practical removing These can be utilized fertilizers, especially soils contaminated Fe Ni, while providing Mallow plant (Corchorus olitorius) nutrients Zn.

Язык: Английский

Процитировано

0
Role of diet in the development of oxidative stress DOI

Rubia Farid,

Salma Siddiqui,

Zeba Haque

и другие.

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 43 - 60

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Protective effect of ginseng seed oil nanoemulsion against human coronavirus OC43 through modulation of ABCG transporters DOI Creative Commons

Sanjeevram Dhandapania,

Rongbo Wang, Abdus Samad

и другие.

Journal of Functional Foods, Год журнала: 2024, Номер 117, С. 106240 - 106240

Опубликована: Май 20, 2024

Recent studies have highlighted the potential of unsaturated fatty acids in natural oils to influence virus replication. This study extracted ginseng seed oil (GSO) and evaluated its physiochemical parameters, lipid class, oxidation stability. GSO was then synthesized into an oil/water nanoemulsion (NE) through optimized formulation, time, temperature, storage conditions. GSO-NE showed no cytotoxicity up 5 µg/mL but effectively inhibited HCoV-OC43 replication suppressed proinflammatory biomarkers infected cells. RNA sequencing revealed significant alterations gene expression profile by treatment, particularly implicating ABC transporters signaling pathway. Notably, downregulated ABCG subfamily membrane proteins, crucial for regulation virus-infected The downregulation these genes (ABCG1, ABCG2, ABCG4, ABCG5/8) reversed GSO-NE, as demonstrated qRT-PCR. Furthermore, ABCG1 ABCG5/8 confirmed using immunoblotting techniques. These findings suggest a promising avenue future research or therapeutic applications.

Язык: Английский

Процитировано

0