Microencapsulation of glutathione through water/oil emulsification and complex coacervation: Improved encapsulation efficiency, physicochemical stability, and sustained release effect
Jingyang Yu,
Ge Du,
Yishun Yao
и другие.
Food Research International,
Год журнала:
2025,
Номер
202, С. 115723 - 115723
Опубликована: Янв. 10, 2025
Язык: Английский
Red emitting carbon dots for detection of endogenous glutathione with fluorescence enhancement and cell imaging
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy,
Год журнала:
2025,
Номер
333, С. 125901 - 125901
Опубликована: Фев. 13, 2025
Язык: Английский
Magnesium ions enhance biogenic amine degradation by Pichia kudriavzevii MZ5: Insights from transcriptomics and novel recombinant enzyme expression
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 141617 - 141617
Опубликована: Фев. 1, 2025
Язык: Английский
Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 403 - 403
Опубликована: Март 13, 2025
Background:
Carotenoids
are
bioactive
tetraterpenoid
C40
pigments
that
actively
synthesized
by
plants,
bacteria,
and
fungi.
Compounds
such
as
α-carotene,
β-carotene,
lycopene,
lutein,
astaxanthin,
β-cryptoxanthin,
fucoxanthin,
zeaxanthin
have
attracted
increasing
attention
for
their
antiaging
properties.
They
exhibit
antioxidant,
neuroprotective,
anti-inflammatory
properties,
contributing
to
the
prevention
treatment
of
age-related
diseases.
Objectives:
The
aim
this
study
was
comprehensively
analyze
pharmacological
potential
biological
mechanisms
carotenoids
associated
with
disorders
evaluate
application
in
nutraceuticals,
pharmaceuticals,
cosmeceuticals.
Methods:
A
systematic
review
studies
published
over
past
two
decades
conducted
using
databases
PubMed,
Scopus,
Web
Science.
selection
criteria
included
clinical,
silico,
vivo,
vitro
investigating
therapeutic
effects
carotenoids.
Results:
demonstrate
a
variety
health
benefits,
including
macular
degeneration,
cancer,
cognitive
decline,
metabolic
disorders,
skin
aging.
Their
role
nutraceuticals
is
well
supported
ability
modulate
oxidative
stress
inflammatory
pathways.
In
show
promising
results
formulations
targeting
neurodegenerative
diseases
disorders.
cosmeceuticals,
they
improve
protecting
it
against
UV
radiation
damage.
However,
bioavailability,
optimal
dosages,
toxicity,
interactions
other
compounds
remain
critical
factors
maximize
efficacy
still
require
careful
evaluation
scientists.
Conclusions:
interventions
applications
fields.
Further
research
needed
optimize
formulas,
confirm
long-term
safety
effectiveness,
especially
aging
population.
Язык: Английский
A new one-pot technique for obtaining potential indapamide metabolites by oxidation and conjugation on MALDI target
Опубликована: Март 22, 2025
Introduction.
Metabolic
activation
of
xenobiotics,
including
pharma
drugs,
is
considered
to
be
one
the
main
mechanisms
for
development
idiosyncratic
reactions.
Accordingly,
potential
bioactivation
a
xenobiotic
should
carefully
evaluated
in
early
stages
drug
development.
In
this
regard,
search
new
rapid
and
effective
screening
techniques
reactive
metabolites
xenobiotics
presents
particular
interest.
Objective
.
Development
technique
modeling
processes
biotransformation
vitro
identify
indapamide.
Materials
methods
Non-enzymatic
instrumental
methods,
such
as
electrochemical
oxidation
(ECO)
photocatalytic
(PCO)
volume,
were
used
comparison
methods.
The
second
phase
metabolism
was
modeled
by
incubating
products
indapamide
with
trapping
agent
(glutathione,
GSH).
products,
well
their
conjugates
GSH,
then
analyzed
high-performance
liquid
chromatography–tandem
mass
spectrometry
(HPLC–MS/MS).
developed
one-pot
based
on
UV-induced
PCO
presence
GSH
surface
target
functionalized
titanium
dioxide
followed
detection
matrix-assisted
laser
desorption/ionization
(MALDI).
Results.
use
ECO
resulted
5
3
adducts
while
volume
allowed
7
1
adduct
GSH.
detected
8
addition
number
known
total
4
previously
unstudied
each
three
Conclusions.
proposed
analytical
showed
its
higher
informativity
combined
simplicity
rapidity,
which
makes
it
promising
candidate
preclinical
studies
drugs
predicting
toxicity
pharmaceutical
objects,
studying
various
xenobiotics.
Язык: Английский
Knockdown of SLC7A5 inhibits malignant progression and attenuates oxaliplatin resistance in gastric cancer by suppressing glycolysis
Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Март 25, 2025
Abstract
Background
Chemotherapy
resistance
is
a
major
challenge
in
the
treatment
of
intermediate
and
advanced
gastric
cancer
(GC).
This
study
aimed
to
recognize
oxaliplatin
resistance-related
genes
(OXARGs)
GC
explore
their
role
mechanism
GC.
Methods
OXARGs
with
prognostic
value
were
analyzed
using
data
from
GEO
TCGA
databases.
RT-qPCR
WB
assay
applied
verify
expression
MT2A,
NOTCH1
SLC7A5
oxaliplatin-resistant
cells
(HGC27R
MKN45R).
The
effect
on
malignant
phenotype
was
verified
by
CCK-8,
EDU,
TUNEL,
colony
formation,
wound
healing,
transwell
assay,
tumor
bearing
experiments
assay.
Results
Bioinformatics
analysis
experimental
validation
indicate
that
target
for
oxaliplatin-resistance
Knockdown
obviously
decreased
viability,
migration,
invasion
vitro
growth
vivo.
It
also
increased
apoptosis
levels
BAX
expression,
reduced
BCL2,
MMP
2
MMP9.
Additionally,
knockdown
enhanced
sensitivity
both
Furthermore,
downregulated
HK2,
LDHA,
Glut1,
PDK1
vivo
vitro,
leading
extracellular
glucose
lactate
levels.
However,
glutathione
significantly
attenuated
regulatory
cells.
Trial
registration
Not
Applicable.
Conclusion
inhibits
progression
attenuates
suppressing
glycolysis.
Язык: Английский
Alcohol exposure alters the diversity and composition of oral microbiome
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 7, 2025
Introduction
Alcohol
exposure
has
been
shown
to
have
complex,
and
sometimes
paradoxical,
associations
with
various
serious
diseases.
Currently,
there
is
no
knowledge
about
the
effects
of
alcohol
on
dynamics
oral
microbial
communities.
Objective
The
study
aims
investigate
chronic
consumption
diversity
composition
rat
microbiota
using
16S
rRNA
gene
amplicon
sequencing.
Methods
In
our
study,
were
2
groups,
including
a
control
group
(C
group)
an
(A
group),
10
rats
in
every
group.
For
ten
weeks,
A
treated
intragastrically
day,
whereas
C
got
water.
After
serum
levels
alanine
aminotransferase
(ALT)
aspartate
(AST)
measured.
Oral
swabs
taken
from
both
total
DNA
was
extracted
for
high-throughput
sequencing
gene.
Results
According
results
obtained
significant
differences
observed
relative
abundances
Alpha
measures
statistically
significantly
higher
(P
<
0.05)
compared
At
genus
level,
altered
abundance
several
microbes,
increased
unidentified_Chloroplast,
Acinetobacter,
Vibrio,
Romboutsia,
Pseudoalteromonas,
Aeromonas,
Ralstonia,
Turicibacter,
Shewanella
,
Bacteroides
.
Conversely,
Haemophilus
Streptococcus
less
abundant
Conclusion
associated
microbiome.
These
findings
contribute
understanding
potential
role
bacteria
alcohol-related
systemic
diseases,
providing
foundational
work
future
prevention
intervention
studies.
Язык: Английский
Identification of QTLs and candidate genes screening for hypoxia tolerance in Pacific white shrimp (Litopenaeus vannamei)
Aquaculture Reports,
Год журнала:
2025,
Номер
42, С. 102824 - 102824
Опубликована: Апрель 19, 2025
Язык: Английский
Nanozyme-mediated glutathione depletion for enhanced ROS-based cancer therapies: a comprehensive review
Nanomedicine,
Год журнала:
2024,
Номер
20(3), С. 279 - 290
Опубликована: Дек. 27, 2024
Nanozymes
can
improve
reactive
oxygen
species
(ROS)-based
cancer
therapies
by
targeting
cells'
antioxidant
defense
mechanisms,
particularly
glutathione
(GSH)
depletion,
to
overcome
ROS-resistant
cells.
Nanozymes,
innovative
enzyme-mimetic
nanomaterials,
generate
ROS,
alter
the
tumor
microenvironment
(TME),
and
synergize
with
photodynamic
therapy
(PDT),
chemodynamic
(CDT),
radiotherapy,
immunotherapy.
This
review
shows
how
nanozymes
catalyze
ROS
generation,
selectively
deplete
GSH,
target
elimination,
offering
clear
advantages
over
standard
therapies.
defenses
PDT,
CDT,
radiation
To
maximize
nanozyme-based
treatment
efficacy,
biodistribution,
biocompatibility,
heterogeneity
must
be
assessed.
treatment,
multifunctional,
stimuli-responsive
synergistic
combination
drugs
should
developed.
Язык: Английский