Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell DOI Creative Commons
Ioannis Paraskevaidis, Christos Kourek, Dimitrios Farmakis

и другие.

Biomolecules, Год журнала: 2024, Номер 14(12), С. 1534 - 1534

Опубликована: Ноя. 29, 2024

Myocardial cells and the extracellular matrix achieve their functions through availability of energy. In fact, mechanical electrical properties heart are heavily dependent on balance between energy production consumption. The produced is utilized in various forms, including kinetic, dynamic, thermal Although total remains nearly constant, contribution each form changes over time. Thermal increases, while dynamic kinetic decrease, ultimately becoming insufficient to adequately support cardiac function. As a result, toxic byproducts, unfolded or misfolded proteins, free radicals, other harmful substances accumulate within myocardium. This leads failure crucial processes such as myocardial contraction–relaxation coupling, ion exchange, cell growth, regulation apoptosis necrosis. Consequently, both micro- macro-architecture altered. Energy consumption depend heart’s metabolic resources functional state structure, cardiomyocytes, non-cardiomyocyte cells, energetic behavior. Mitochondria, which intracellular organelles that produce more than 95% ATP, play critical role fulfilling all these requirements. Therefore, it essential gain deeper understanding anatomy, function, homeostatic properties.

Язык: Английский

Mitochondria and the Repurposing of Diabetes Drugs for Off-Label Health Benefits DOI Open Access
Joyce Yip, Grace Shu Hui Chiang,

I Lee

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(1), С. 364 - 364

Опубликована: Янв. 3, 2025

This review describes our current understanding of the role mitochondria in repurposing anti-diabetes drugs metformin, gliclazide, GLP-1 receptor agonists, and SGLT2 inhibitors for additional clinical benefits regarding unhealthy aging, long COVID, mental neurogenerative disorders, obesity. Metformin, most prominent these diabetes drugs, has been called “Drug Miracles Wonders,” as trials have found it to be beneficial human patients suffering from maladies. To promote viral replication all infected cells, SARS-CoV-2 stimulates liver cells produce glucose export into blood stream, which can cause COVID patients, reduces levels blood, was shown cut incidence rate half recovering SARS-CoV-2. Metformin leads phosphorylation AMP-activated protein kinase AMPK, accelerates import via transporter GLUT4 switches starvation mode, counteracting virus. Diabetes also stimulate unfolded response thus mitophagy, is healthy aging health. were mimic exercise help reduce body weight.

Язык: Английский

Процитировано

0
Empagliflozin Plays Vasoprotective Role in Spontaneously Hypertensive Rats via Activation of the SIRT1/AMPK Pathway DOI Creative Commons
Monika Kloza, Anna Krzyżewska, Hanna Kozłowska

и другие.

Cells, Год журнала: 2025, Номер 14(7), С. 507 - 507

Опубликована: Март 29, 2025

Empagliflozin (EMPA), a sodium-glucose co-transporter 2 (SGLT2) inhibitor, prevents endothelial dysfunction, but its effects on vascular tone in hypertension remain unclear. This study investigated whether EMPA modulates vasomotor via sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) pathways spontaneously hypertensive rats (SHR) controls (Wistar Kyoto rats, WKY). Functional (wire myography, organ bath) biochemical (Western blot) studies were conducted the third-order of superior mesenteric arteries (sMAs) and/or aortas. induced concentration-dependent relaxation preconstricted sMAs both groups. In SHR, enhanced acetylcholine (Ach)-induced aortas reduced constriction by phenylephrine (Phe) U46619 sMAs. The SIRT1 inhibitor (EX527) abolished EMPA’s Ach-mediated U46619-induced vasoconstriction, while AMPK inhibition Phe-induced vasoconstriction. SHR showed increased SGLT2 expression decreased pAMPK/AMPK levels conclusion, might exert vasoprotective enhancing endothelium-dependent reducing AMPK/SIRT1 pathways. These properties could improve health patients with related conditions. Further are needed to explore new indications for inhibitors.

Язык: Английский

Процитировано

0
The Role of SGLT1 in Atrial Fibrillation and Its Relationship with Endothelial-Mesenchymal Transition DOI

Zhi-Hong Ning,

Xianding Wang,

Huifang Tang

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 748, С. 151338 - 151338

Опубликована: Янв. 14, 2025

Язык: Английский

Процитировано

0
Mitochondrial Dysfunction in Cardiac Disease: The Fort Fell DOI Creative Commons
Ioannis Paraskevaidis, Christos Kourek, Dimitrios Farmakis

и другие.

Biomolecules, Год журнала: 2024, Номер 14(12), С. 1534 - 1534

Опубликована: Ноя. 29, 2024

Myocardial cells and the extracellular matrix achieve their functions through availability of energy. In fact, mechanical electrical properties heart are heavily dependent on balance between energy production consumption. The produced is utilized in various forms, including kinetic, dynamic, thermal Although total remains nearly constant, contribution each form changes over time. Thermal increases, while dynamic kinetic decrease, ultimately becoming insufficient to adequately support cardiac function. As a result, toxic byproducts, unfolded or misfolded proteins, free radicals, other harmful substances accumulate within myocardium. This leads failure crucial processes such as myocardial contraction–relaxation coupling, ion exchange, cell growth, regulation apoptosis necrosis. Consequently, both micro- macro-architecture altered. Energy consumption depend heart’s metabolic resources functional state structure, cardiomyocytes, non-cardiomyocyte cells, energetic behavior. Mitochondria, which intracellular organelles that produce more than 95% ATP, play critical role fulfilling all these requirements. Therefore, it essential gain deeper understanding anatomy, function, homeostatic properties.

Язык: Английский

Процитировано

1