Recent Advancement in the Conversion of 1,2,3‐Benzotriazin‐4(3H)‐One to Other Heterocyclic Systems and Their Applications: A Concise Review
ChemistrySelect,
Год журнала:
2025,
Номер
10(5)
Опубликована: Фев. 1, 2025
Abstract
The
nitrogen
containing
1,2,3‐benzotriazin‐4(3
H
)‐one
is
structurally
worthwhile
system
for
its
notable
applications
in
the
synthesis
of
N─
,
O
─
and
S─
heterocycles
bears
pivotal
significant
usage
pharmaceutical
industrial
chemicals.
Today
most
common
items
like
dyes,
cosmetics,
sanitizers,
insecticides
plastics
are
based
on
heterocyclic
moieties.
Different
starting
materials
used
industrially
formation
diverse
but
a
valuable
structure
to
prepare
numerous
products.
These
conversions
radiation
or
metal‐catalyzed
denitrogenation
annulation
type
reactions
provide
easy,
one‐step
atom‐economical
route.
vast
significance
their
cheap
make
this
subject
interesting
scientific
researchers
industrialists.
This
mini
review
summarizes
recent
developments
transformation
ring
various
other
structures
phenanthridinones,
isoquinolones,
coumarin‐1‐imines,
benzamides,
pyrroloquinazolinones,
indolin‐1‐ones,
1,2‐benzisoselenazol‐3(2
)‐ones
benzofuranones.
Some
emerging
drugs
ebselen,
losartan,
irbesartan,
luotonin
A,
deoxyvasicinone
mackinazolinone
have
been
successfully
synthesized
from
differently
substituted
benzotriazinones.
Язык: Английский
Overcoming High Reduction Potentials via Consecutive Mechanical-Force-Induced Electron Transfer Strategy
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Abstract
Mechanical-force-induced
redox
catalysis
has
recently
advanced
rapidly,
emerging
as
a
green
and
innovative
tool
in
synthetic
chemistry.
The
foundation
of
this
strategy
lies
the
single
electron
transfer
(SET)
from
polarized
piezoelectric
materials
to
substrates,
which
is
initiated
by
potential
generated
through
mechanical
agitation.
magnitude
primarily
influenced
intrinsic
properties
material.
In
certain
circumstances,
however,
may
be
insufficient
trigger
SET
process,
akin
limitations
visible-light
excitation
photocatalytic
reactions.
This
challenge
motivated
us
explore
effective
solutions.
work,
we
establish
catalytic
system
that
utilizes
consecutive
mechanical-force-induced
(ConMET)
strategy.
novel
employs
mechanochemical
catalysts,
with
9-phenyl-dihydroacridine
(
D1)
serving
sacrificial
donors,
facilitating
produce
significantly
more
powerful
reductive
species
during
grinding.
Our
approach
effectively
promotes
reduction
aryl
iodides,
bromides
even
electron-rich
chlorides,
possess
potentials
high
−
2.8
V
(vs.
SCE),
leading
formation
radicals.
Ultimately,
enables
anti-Markovnikov
hydroarylation
alkenes
dehalogenative
deuteration
aromatic
halides
(Cl,
Br)
under
mild
conditions.
Язык: Английский
Mechanoredox-Enabled Isothiocyanation of Primary Amines Using Piezoelectric Material as the Redox Catalyst
The Journal of Organic Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
A
novel
mechanoredox-enabled
synthesis
of
aromatic
and
aliphatic
isothiocyanates
from
primary
amines
carbon
disulfide
under
ball
milling
conditions
using
a
piezoelectric
material
(BaTiO3)
as
the
redox
catalyst
has
been
developed.
This
method
displays
several
features,
such
short
reaction
time,
operational
simplicity,
room
temperature
air
conditions,
minimal
solvent,
broad
substrate
scope,
recyclable
cheap
catalyst.
Preliminary
mechanistic
studies
revealed
that
highly
polarized
acted
single-electron
transfer
(SET)
oxidation
reagent
for
key
desulfurization
process.
Язык: Английский
Mechanochemical Radical Transformations in Organic Synthesis
Chemistry - A European Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 22, 2024
Abstract
Organic
synthesis
has
historically
relied
on
solution‐phase,
polar
transformations
to
forge
new
bonds.
However,
this
paradigm
is
evolving,
propelled
by
the
rapid
evolution
of
radical
chemistry.
Additionally,
organic
witnessing
a
simultaneous
resurgence
in
mechanochemistry,
formation
bonds
solid‐state,
further
contributing
shift
status
quo.
The
aforementioned
advances
chemistry
have
predominantly
occurred
solution
phase,
while
majority
mechanochemical
feature
transformations.
Herein,
we
discuss
rapidly
advancing
area
synthesis:
reactions.
Solid‐state
reactions
offer
improved
green
metrics,
better
reaction
outcomes,
and
access
intermediates
products
that
are
difficult
or
impossible
reach
solution.
This
review
explores
these
context
small
molecule
synthesis,
from
early
findings
current
state‐of‐the‐art,
underscoring
pivotal
role
solid‐state
likely
play
sustainable
chemical
synthesis.
Язык: Английский