Oxidative Stress in the Pathogenesis of Neurodegenerative Diseases DOI Creative Commons
Maria Carolina Jurcău, Anamaria Jurcău,

Radu Diaconu

и другие.

Stresses, Год журнала: 2024, Номер 4(4), С. 827 - 849

Опубликована: Дек. 2, 2024

Neurodegenerative diseases are devastating conditions with a rising incidence and prevalence due to the aging of population for which we currently do not have efficient therapies. Despite compelling evidence provided by basic research on involvement oxidative stress in their pathogenesis, most trials antioxidants failed. The reasons may relate low bioavailability used compounds or starting therapy late, when pathogenic cascades already induced irreversible damage. current review discusses sources central nervous system, reactive oxygen species pathogenesis Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, importance further improved delivery methods as well search biomarkers that could help early diagnosis hope finding more therapies these diseases.

Язык: Английский

Dysfunctional mitochondria in age-related neurodegeneration: Utility of melatonin as an antioxidant treatment DOI Creative Commons
Russel J. Reıter, Ramaswamy Sharma, Walter Manucha

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 101, С. 102480 - 102480

Опубликована: Сен. 3, 2024

Mitochondria functionally degrade as neurons age. Degenerative changes cause inefficient oxidative phosphorylation (OXPHOS) and elevated electron leakage from the transport chain (ETC) promoting increased intramitochondrial generation of damaging reactive oxygen nitrogen species (ROS RNS). The associated progressive accumulation molecular damage causes an increasingly rapid decline in mitochondrial physiology contributing to aging. Melatonin, a multifunctional free radical scavenger indirect antioxidant, is synthesized matrix neurons. Melatonin reduces ETC elevates ATP production; it also detoxifies ROS/RNS via SIRT3/FOXO pathway upregulates activities superoxide dismutase 2 glutathione peroxidase. influences glucose processing by In neurogenerative diseases, often adopt Warburg-type metabolism which excludes pyruvate mitochondria causing reduced acetyl coenzyme A production. Acetyl supports citric acid cycle OXPHOS. Additionally, required co-substrate for arylalkylamine-N-acetyl transferase, rate limits melatonin synthesis; therefore, production diminished cells that experience making more vulnerable stress. Moreover, endogenously produced diminishes during aging, further increasing components. More normal preserved aging with supplementation.

Язык: Английский

Процитировано

12
Role of environmental pollutants-induced ferroptosis in pulmonary diseases DOI Creative Commons
Long Yang, Yuan Qiao, Zeyu Huang

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 24, 2025

Respiratory diseases rank among the foremost causes of mortality and disability globally, with long-term exposure to environmental pollutants playing a critical role in their onset progression. Despite this, underlying mechanisms effective targeted treatments for these disorders remain poorly understood, highlighting an urgent need focused research. Cell death, programmed cellular response external harmful stimuli, including ferroptosis-a recently identified form iron-dependent cell death-emerges as pivotal process. Characterized by intracellular iron accumulation lipid peroxidation, ferroptosis appears intricately linked lung injury induced pollutants. This review examines triggered factors, aiming shed light on its specific pathophysiological potential therapeutic target. By deepening our understanding interactions between pollution, ferroptosis, damage, we hope inform strategies intervention.

Язык: Английский

Процитировано

0
Ferroptosis as a key player in the pathogenesis and intervention therapy in liver injury: focusing on drug-induced hepatotoxicity DOI

Bahaa Ibrahim Saeed,

Subasini Uthirapathy,

Aziz Kubaev

и другие.

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0
Melatonin supplementation attenuates cuproptosis and ferroptosis in aging cumulus and granulosa cells: potential for improving IVF outcomes in advanced maternal age DOI Creative Commons
Kuan‐Hao Tsui, Chia‐Jung Li, Li‐Te Lin

и другие.

Reproductive Biology and Endocrinology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 8, 2024

Advanced maternal age is associated with decreased oocyte quantity and quality in vitro fertilization (IVF) success rates. This study aimed to investigate whether melatonin supplementation can improve IVF outcomes women of advanced by modulating cuproptosis ferroptosis.

Язык: Английский

Процитировано

1
Oxidative Stress in the Pathogenesis of Neurodegenerative Diseases DOI Creative Commons
Maria Carolina Jurcău, Anamaria Jurcău,

Radu Diaconu

и другие.

Stresses, Год журнала: 2024, Номер 4(4), С. 827 - 849

Опубликована: Дек. 2, 2024

Neurodegenerative diseases are devastating conditions with a rising incidence and prevalence due to the aging of population for which we currently do not have efficient therapies. Despite compelling evidence provided by basic research on involvement oxidative stress in their pathogenesis, most trials antioxidants failed. The reasons may relate low bioavailability used compounds or starting therapy late, when pathogenic cascades already induced irreversible damage. current review discusses sources central nervous system, reactive oxygen species pathogenesis Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis, importance further improved delivery methods as well search biomarkers that could help early diagnosis hope finding more therapies these diseases.

Язык: Английский

Процитировано

1