Nanoparticle-Based Delivery Systems for Phytochemicals in Cancer Therapy: Molecular Mechanisms, Clinical Evidence, and Emerging Trends

Drug Development and Industrial Pharmacy, Год журнала: 2025, Номер unknown, С. 1 - 31

Опубликована: Март 21, 2025

This review examines recent advancements in nanoparticle-based delivery systems for phytochemicals, focusing on their role overcoming multidrug resistance, improving therapeutic efficacy, and facilitating clinical translation. highlights advances nanoparticle-enabled phytochemical to enhance bioavailability, improve outcomes, enable targeted applications. By comparing various nanoparticle systems, formulation methods, efficacy data, it identifies gaps current research guides the development of more effective, next-generation phytochemical-loaded nanocarriers. A systematic literature published between 2000 2024 was conducted using PubMed, Scopus, Web Science. Articles cancer therapy were included. Compounds such as curcumin, resveratrol, quercetin, epigallocatechin gallate demonstrate enhanced anti-cancer when encapsulated nanoparticles, leading improved increased tumor cell targeting, reduced toxicity. Clinical trials indicate regression fewer adverse effects. Emerging approaches-such nanogels, hybrid combination therapies with immune checkpoint inhibitors-further refine treatment efficacy. Nanoparticle-based significantly potential making them promising candidates safer, effective treatments. However, challenges related regulatory guidelines, scalability, long-term safety must be addressed fully realize potential.

Язык: Английский

---

Formation and stabilization mechanism of Ginsenoside Rg3 inclusion complexes based on molecular simulation

Pharmaceutical Development and Technology, Год журнала: 2025, Номер unknown, С. 1 - 18

Опубликована: Янв. 2, 2025

The formation of inclusion complexes between Ginsenoside Rg3 and cyclodextrins represents a promising strategy to enhance the solubility G-Rg3. Nevertheless, molecular mechanisms underlying interaction G-Rg3 have yet be fully elucidated. In this study, we employed combination simulation experimental methodologies identify most effective solubilizing carriers among G-Rg3, β-cyclodextrin (β-CD), 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), 2,6-dimethyl-β-cyclodextrin (DM-β-CD). formed with HP-β-CD demonstrates superior stability water compared those β-CD DM-β-CD. preparation process for was optimized through an orthogonal testing approach. optimal conditions were determined mass ratio 1:125, time 2 h, temperature 30 °C. confirmed using DSC, Fourier Transform Infrared FTIR, XRD techniques. vitro tests indicated that 2.9 times greater than Molecular dynamics (MD) simulations provided insights into stabilize their solubility. primary force identified as van der Waals force.

Язык: Английский

---

Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota

Frontiers in Pharmacology, Год журнала: 2025, Номер 15

Опубликована: Янв. 8, 2025

Minor ginsenosides have demonstrated promising anticancer effects in previous reports. Total minor (TMG) were obtained through the fermentation of major with Lactiplantibacillus plantarum, and potential TMGs on mouse colon cancer cell line CT26.WT, vitro vivo, investigated. We employed Cell Counting Kit-8 (CCK-8), TdT-mediated dUTP nick end labeling (TUNEL), Western blot analysis to explore anti-proliferative pro-apoptotic functions TMG CT26.WT cells. In a xenograft model was established by subcutaneously injecting mice cells administering dose 100 mg/kg/day tumor-bearing mice. The level apoptosis expression various proteins tumor tissues detected immunohistochemistry blot. High-throughput 16S rRNA sequencing used determine alterations gut microbiota. studies that significantly inhibited proliferation promoted Interestingly, induced affecting Bax/Bcl-2/caspase-3 pathway. Furthermore, result transplanted indicated substantially enhanced activities Bax caspase-3, reduced activity Bcl-2, suppressed Raf/MEK/ERK protein levels. Fecal revealed reconstructed microbiota colorectal cancer-affected augmenting abundance advantageous bacterium Lactobacillus decreasing harmful Proteus. can exhibit potent anti-colorectal diverse apoptotic mechanisms, their mode action closely related regulation

Язык: Английский

---

Changes in the chemical composition and medicinal effects of black ginseng during processing

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 11, 2024

To study the changes in chemical composition and medicinal effects of black ginseng during processing.

Язык: Английский

---

Research Progress of Effects of GRg3 on Intestinal Flora in Patients with Radiotherapy for Rectal Cancer

Advances in Clinical Medicine, Год журнала: 2024, Номер 14(12), С. 214 - 219

Опубликована: Янв. 1, 2024

Язык: Английский

---