Soybean Sprout Peptides Alleviate Obesity via PI3K-Akt and JAK-STAT Pathway Modulation, Gut Microbiota Regulation, and Metabolic Reprogramming

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Obesity is a growing global health concern associated with severe metabolic disorders, necessitating the development of safer and more effective therapeutic strategies. Soybean sprout peptides (SSPs), derived from germinated soybeans, are bioactive compounds potential antiobesity effects. This study aimed to investigate molecular mechanisms SSPs through an integrated approach combining network pharmacology, docking, in vivo experiments. SSP sequences were identified using UPLC-Orbitrap-MS/MS, their bioactivity was predicted PeptideRanker. Network pharmacology key targets, including AKT1, SRC, STAT3, ESR1, FOS, NFKB1, which implicated PI3K-Akt JAK-STAT pathways. Molecular docking validated strong interactions between these targets. In vivo, administration significantly reduced body weight gain, abdominal fat accumulation, serum lipid abnormalities high-fat-diet-induced obese mice while modulating gut microbiota composition by restoring Firmicutes-to-Bacteroidetes ratio reducing pathogenic taxa. Fecal metabolomics revealed that alleviated oxidative stress improved amino acid metabolism, contributing its These findings suggest holds promise as functional food ingredient or nutraceutical for obesity prevention management.

Язык: Английский

Copper oxide nanoparticles induce non-alcoholic fatty liver disease by disrupting bile acid homeostasis and perturbing the intestinal microbial homeostasis

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136416 - 136416

Опубликована: Ноя. 5, 2024

Язык: Английский

Cassia mimosoides L. decoction improves non-alcoholic fatty liver disease by modulating the pregnane X receptor

Journal of Ethnopharmacology, Год журнала: 2024, Номер unknown, С. 119199 - 119199

Опубликована: Дек. 1, 2024

Язык: Английский