Independent organelle and organelle—organelle interactions: essential mechanisms for malignant gynecological cancer cell survival

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 22, 2024

Different eukaryotic cell organelles (e.g., mitochondria, endoplasmic reticulum, lysosome) are involved in various cancer processes, by dominating specific cellular activities. Organelles cooperate, such as through contact points, complex biological activities that help the regulate energy metabolism, signal transduction, and membrane dynamics, which influence survival process. Herein, we review current studies of mechanisms lysosome related to three major malignant gynecological cancers, their possible therapeutic interventions drug targets. We also discuss similarities differences independent organelle organelle-organelle interactions, applications respective cancers; mitochondrial dynamics reticulum dysfunction, lysosomal regulation autophagy, regulatory death play crucial roles tumorigenesis, progression, response therapy. Finally, value research, its problems, future directions.

Язык: Английский

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Aging and Bioenergetics of Mitochondria

Advances in biochemistry in health and disease, Год журнала: 2024, Номер unknown, С. 285 - 303

Опубликована: Янв. 1, 2024

Язык: Английский

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