Linking Immunological Parameters and Recovery of Patient’s Motor and Cognitive Functions In The Acute Period of Ischemic Stroke
General Reanimatology,
Год журнала:
2024,
Номер
20(1), С. 4 - 14
Опубликована: Фев. 19, 2024
Objective
.
To
evaluate
the
relationship
between
immunological
parameters
and
functional
outcome
in
patients
with
varying
severity
of
ischemic
stroke
based
on
statistical
methodology.
Materials
methods.
The
prospective
study
included
78
diagnosed
stroke,
who
were
distributed
into
two
groups:
group
1
—
38
mild
patients,
NIHSS
score
<
5,
2
40
moderate
5–15.
Signs
severity,
degree
disability,
cognitive
decline,
activities
daily
living
chosen
as
criteria
to
estimate
by
calculating
difference
NIHSS,
mRS,
MoCA,
BI
scales
at
time
admission
Day
12
hospital
stay.
Lab
tests
assessment
plasma
concentrations
CXC
CC
subfamilies
cytokines,
interleukins
TNF-a
Machine
learning
algorithms,
Python
programming
language,
Pandas
SciPy
libraries,
discriminant
analysis
used
for
processing.
Results.
following
found
significant:
IL-1b
MPIF-1/CCL23
1,
IL-16,
MPIF-1/CCL23,
Eotaxin-2/CCL24,
Gro-a/CXCL1
IL-8/CXCL8
patients.
Positive
correlation
was
established
dynamics
(
R
=0.227,
P
=0.001),
=0.380,
=0.00061)
=0.211,
=0.00001),
changes
mRS
=0.277,
=0.00006),
=0.0075)
IL-16
=0,
211,
=0.00001).
There
a
significant
negative
dysfunction
Eotaxin-2/CCL24
=–0.378,
=0.00075),
=–0.313,
=0.0035),
IP-10/CXCL1
=–0.214,
=0.00023),
limited
(IB)
=–0.345,
=0.0024)
=–0.210,
Conclusion.
Chemokines
form
family
CXC-Gro-a/CXCL1
clusters
are
principal
cytokines
associated
patient’s
motor
functions
recovery
acute
period
stroke.
Although
obtained
results
demonstrate
effect
increased
Gro-a/CXCL1,
improvement
impairments,
further
studies
needed
verify
chemokines
prognostic
markers
Язык: Английский
Immunological status of patients in the acute period of ischemic stroke
Russian neurological Journal,
Год журнала:
2024,
Номер
29(3), С. 24 - 31
Опубликована: Июль 24, 2024
The
purpose
of
this
study
was
to
assess
immunological
status
and
correlations
cytokines
diff
erent
groups
in
patients
the
acute
period
ischemic
stroke
(IS).
Material
methods.
80
with
IS
(treatment
group)
20
cardiovascular
diseases
(control
were
examined.
All
assessed
for
comorbidity,
cognitive
function
demographic
characteristics.
following
IS:
subtype,
functional
using
Barthel
Index
(BI),
Ranking
scale
(mRS),
National
Institutes
Health
Stroke
Scale
(NIHSS),
neuroimaging
parameters.
Laboratory
diagnosis
included
assessment
serum
concentrations
interleukins,
interferons,
CXC-
CC-chemokines,
MIF,
GM-CSF
TNF-α.
Statistical
analyses
performed
Python
its
libraries
Pandas
SciPy.
Results.
Higher
levels
IFN-γ,
CXCL1,
CCL23
determined
IS.
CXCL1
found
correlate
BI,
NIHSS,
MoCA,
foci
size;
IL
—
6
presence
diabetes,
overweight;
IFN-γ
hyperlipidemia,
NIHSS.
associated
mRS
at
day
14,
atherosclerosis,
atherothrombotic
subtype
IS;
CCL2
leukoaraiosis,
hypertension;
CXCL8
diabetes.
Conclusion.
research
level
differential
expression
is
an
actual
direction
clinical
medicine.
verifi
cation
CXCL8,
CCL23,
CCL2,
IL-6
as
potential
biomarkers
severity,
course
outcomes
AI
requires
clarifi
through
further
studies.
Язык: Английский