A systematic review and meta-analysis of randomized controlled trials for physical activity among colorectal cancer survivors: directions for future research

PeerJ, Год журнала: 2025, Номер 13, С. e18892 - e18892

Опубликована: Янв. 31, 2025

Physical activity (PA) is critically important to cancer rehabilitation. However, PA levels are generally lower in colorectal (CRC) survivors compared other survivors. The purpose of this study was examine the effectiveness interventions increasing and provide recommendations for developing CRC A systematic literature search conducted Cochrane Library, Embase, PubMed, Scopus, Web Science, China National Knowledge Infrastructure, Wan Fang Data from January 2010 March 1, 2024. Physiotherapy Evidence Database (PEDro) scale used assess methodological quality eligible studies, Grading Recommendations, Assessment, Development, Evaluations (GRADE) method evaluate certainty evidence. random-effects model meta-analysis, data were analyzed using standardized mean differences 95% confidence intervals. total 22 studies included review, all which rated as having good based on PEDro scale. In nine these involving 684 participants included, results showed that have a positive effect (Z = 2.79, p 0.005). Results subgroup analysis revealed supervised 2.82, 0.005) with multiple intervention components 3.06, 0.002) effectively increased addition, research evidence suggests daily frequency 4.28, < 0.001), Moderate-to-vigorous physical (MVPA) intensity 2.29, 0.022), aerobic combined resistance exercise type 4.19, 0.001) appropriate findings review strong supporting role improving among This offers preliminary insights into patterns (e.g., frequency, intensity, type) enhancing further high-quality clinical trials needed determine optimal timing, duration, delivery methods maximize their population.

Язык: Английский

Do Measures of Real-World Physical Behavior Provide Insights Into the Well-Being and Physical Function of Cancer Survivors? Cross-Sectional Analysis

JMIR Cancer, Год журнала: 2024, Номер 10, С. e53180 - e53180

Опубликована: Июль 15, 2024

Background As the number of cancer survivors increases, maintaining health-related quality life in survivorship is a priority. This necessitates accurate and reliable methods to assess how are feeling functioning. Real-world digital measures derived from wearable sensors offer potential for monitoring well-being physical function survivorship, but questions surrounding clinical utility these remain be answered. Objective In this secondary analysis, we used 2 existing data sets examine real-world behavior, captured with accelerometer, were related aerobic fitness self-reported sample individuals who had completed treatment. Methods Overall, 86 disease-free aged 21-85 years self-report assessments function, as well submaximal exercise test that was estimate their fitness, quantified predicted oxygen uptake (VO2). A thigh-worn accelerometer monitor participants’ behavior 7 days. Accelerometry calculate average values following behavior: sedentary time, step counts, time light moderate vigorous activity, weighted median cadence stepping bouts over 1 minute, peak 30-second cadence. Results Spearman correlation analyses indicated 6 (86%) accelerometry-derived not significantly correlated Functional Assessment Cancer Therapy-General total or linked Patient-Reported Outcomes Measurement Information System-Physical Function scores (Ps≥.08). contrast, all one VO2 (Ps≤.03). Comparing associations using likelihood ratio tests, found activity more strongly associated than minute Conclusions survivors, several function. These results highlight possibility have treatment, may provide additional information compared performance measures. To advance appropriate use oncology research, further research evaluating large, representative samples warranted. Trial Registration ClinicalTrials.gov NCT03781154; https://clinicaltrials.gov/ct2/show/NCT03781154

Язык: Английский