BMC Endocrine Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 18, 2024
Abstract
Objective
Infertility
is
associated
with
obesity.
The
Body
Roundness
Index
(BRI)
a
body
measurement
index
related
to
obesity
that
more
accurately
assesses
and
visceral
fat
levels.
However,
the
relationship
between
BRI
infertility
remains
unclear.
Therefore,
this
study
aims
determine
infertility.
Methods
This
utilized
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2013
2018
included
3,528
women
aged
18–45
years.
Multivariate
logistic
regression
was
employed
investigate
association
Restricted
cubic
spline
(RCS)
analysis
explored
linear
or
non-linear
Interaction
analyses
were
conducted
on
subgroups
validate
findings.
To
verify
robustness
of
results,
we
performed
several
sensitivity
analyses,
including
propensity
score
matching(PSM)
multiple
imputations
for
missing
data.
Furthermore,
predictive
capabilities
various
anthropometric
indices—including
BRI,
weight-adjusted
waist
(WWI),
mass
(BMI),
weight—on
incidence
assessed
using
Receiver
Operating
Characteristic
(ROC)
curve
analysis.
Results
There
significant
positive
After
adjusting
covariates,
each
unit
increase
in
there
12%
probability
(
P
<
0.001).
correlation
persisted
when
categorized
into
quartiles.
Moreover,
as
increased,
trend
towards
higher
prevalence
dose-response
indicated
infertility,
risk.
subgroup
imputations.
ROC
revealed
had
superior
capability
compared
traditional
indices,
an
area
under
(AUC)
0.618
(95%
CI,
0.588–0.648).
Conclusion
results
show
strong
Clinical
trial
number
Not
Applicable.
Journal of Diabetes Investigation,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
ABSTRACT
Objective
To
investigate
the
relationship
between
four
metabolic
indices—visceral
adiposity
index
(VAI),
lipid
accumulation
product
(LAP),
triglyceride
glucose
(TyG)
index,
and
cholesterol‐HDL‐glucose
(CHG)
index—and
presence
of
diabetic
nephropathy
(DN)
retinopathy
(DR)
in
patients
with
long‐standing
type
2
diabetes
mellitus
(T2DM).
Materials
Methods
This
prospective
cross‐sectional
study
included
175
T2DM
disease
duration
>10
years
who
attended
an
endocrinology
outpatient
clinic
July
2021
January
2022.
DR
was
assessed
via
fundus
photography,
DN
defined
using
urinary
albumin‐to‐creatinine
ratio
eGFR.
VAI,
LAP,
TyG,
CHG
indices
were
calculated
anthropometric
biochemical
parameters.
Logistic
regression
used
to
identify
independent
predictors.
Results
The
mean
age
60
±
10.1
years;
63.4%
female.
observed
50.3%
38.9%
patients,
respectively.
TyG
significantly
higher
but
not
DR.
elevated
both
(
P
<
0.05),
only
predictor
=
0.005).
Notably,
proliferative
vs
non‐proliferative
0.009),
unlike
other
indices.
Conclusions
While
associated
nephropathy,
linked
Its
integration
glycemic
parameters
may
offer
greater
sensitivity
for
microvascular
risk
stratification
T2DM.
Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 18, 2024
Objective
The
correlation
between
surrogate
insulin
resistance
(IR)
indices
and
sarcopenic
obesity
(SO)
remains
uncertain.
This
study
aimed
to
assess
the
association
six
IR
surrogates—triglyceride-glucose
(TyG),
TyG-waist
circumference
(TyG-WC),
TyG-waist-to-height
ratio
(TyG-WHtR),
triglyceride-to-high-density
lipoprotein-cholesterol
(TG/HDL),
metabolic
score
for
(METS-IR),
Chinese
visceral
adiposity
index
(CVAI)—and
SO
risk
in
a
middle-aged
older
population
China.
Methods
employed
longitudinal
data
obtained
from
China
Health
Retirement
Longitudinal
Study
(CHARLS)
2011
2015,
involving
6,395
participants.
We
used
multivariate
logistic
regression
models
examine
link
surrogates
SO.
Nonlinear
relationships
were
evaluated
using
restricted
cubic
spline
analysis,
subgroup
analyses
conducted
validation.
Receiver
operating
characteristic
(ROC)
curves
predictive
capabilities.
Results
Over
course
of
4-year
follow-up
period,
319
participants
(5.0%)
developed
In
fully
adjusted
model,
all
significantly
associated
with
odds
ratios
(ORs)
95%
confidence
interval
(95%
CI)
per
standard
deviation
increase
1.21
(1.08–1.36)
TyG,
1.56
(1.39–1.75)
TyG-WC,
2.04
(1.81–2.31)
TyG-WHtR,
1.11
(1.01–1.21)
TG/HDL,
1.67
(1.50–1.87)
METS-IR,
1.74
(1.55–1.97)
CVAI.
Notably,
CVAI
exhibited
nonlinear
correlations
Conversely,
TG/HDL
did
not
exhibit
significant
during
analysis.
Furthermore,
TyG-WHtR
had
larger
area
under
receiver
curve
than
other
indices.
Conclusion
results
indicated
that
positively
incidence.
Meanwhile,
showed
Specifically,
may
be
most
appropriate
indicator
predicting
among
adults.
JMIR Public Health and Surveillance,
Год журнала:
2024,
Номер
10, С. e57799 - e57799
Опубликована: Ноя. 29, 2024
Abstract
Background
Anthropometric
indexes
offer
a
practical
approach
to
identifying
metabolic
syndrome
(MetS)
and
its
components.
However,
there
is
scarcity
of
research
on
anthropometric
tailored
predict
MetS
in
populations
from
resource-limited
regions.
Objective
This
study
aimed
examine
the
association
between
8
easy-to-collect
MetS,
determine
most
appropriate
identify
presence
for
adults
areas.
Methods
A
total
10,520
participants
aged
18‐85
years
Ningxia
Hui
Autonomous
Region,
China,
were
included
this
cross-sectional
study.
Participants
recruited
through
stratified
sampling
January
1,
2020,
December
31,
2021.
was
defined
using
International
Diabetes
Federation
(IDF)
criteria.
Eight
examined,
including
BMI,
waist-to-height
ratio
(WHtR),
weight-adjusted
waist
index
(WWI),
conicity
index,
body
shape
(ABSI),
lipid
accumulation
products
(LAP),
visceral
obesity
(VAI),
triglyceride-glucose
(TyG)
index.
Logistic
regression
analysis
restricted
cubic
splines
(RCSs)
applied
indexes.
The
receiver
operating
characteristic
curve
area
under
(AUC)
analyzed
compare
discriminative
power
MetS.
Youden
used
range
optimal
diagnostic
thresholds.
Results
3324
(31.60%)
diagnosed
with
After
adjusting
age,
ethnicity,
current
residence,
education
level,
habitual
alcohol
consumption,
tobacco
use,
all
positively
correlated
risks
(
P
<.05).
LAP
presented
highest
adjusted
odds
ratios
(adjOR
35.69,
95%
CI
34.59‐36.80),
followed
by
WHtR
29.27,
28.00‐30.55),
11.58,
10.95‐12.22),
TyG
5.53,
5.07‐6.04),
BMI
3.88,
3.71‐4.05),
WWI
3.23,
3.02‐3.46),
VAI
2.11,
2.02‐2.20),
ABSI
1.71,
1.62‐1.80).
Significantly
nonlinear
associations
risk
(all
<.001)
observed
RCSs.
strongest
predictor
males
(AUC
0.91,
0.90-0.92;
cutoff
0.53).
females
0.89,
0.89-0.90;
28.67).
Statistical
differences
present
other
7
among
overall
In
females,
AUC
values
WWI,
ABSI,
VAI,
significantly
different
<.001).
No
statistical
difference
females.
Conclusions
According
lipid-related
indices,
it
suggested
that
are
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Июль 25, 2024
Excessive
visceral
adipose
tissue
(VAT)
is
associated
with
a
spectrum
of
diseases,
including
diabetes,
cancer,
and
cardiovascular
diseases.
Remnant
cholesterol
(RC),
denoting
within
triglyceride-rich
lipoproteins
their
metabolic
byproducts,
has
been
identified
as
key
contributor
to
diseases
related
mortality.
However,
the
association
between
VAT
RC
remains
unclear.
In
this
study,
objective
provide
new
evidence
regarding
concentrations.
Heliyon,
Год журнала:
2024,
Номер
10(17), С. e36683 - e36683
Опубликована: Авг. 23, 2024
To
investigate
sex-specific
differences
in
associations
of
abdominal
obesity
indexes,
systemic
factors,
and
diabetic
retinopathy
(DR)
type
2
diabetes
mellitus
(T2DM)
subjects
with
normal
body
mass
index
(BMI).
International Journal of General Medicine,
Год журнала:
2024,
Номер
Volume 17, С. 5681 - 5696
Опубликована: Дек. 1, 2024
Purpose:
The
purpose
of
this
study
is
to
investigate
the
association
between
Chinese
Visceral
Adipose
Index(CVAI)
and
brachial-ankle
pulse
wave
velocity
(baPWV)
in
type
2
diabetes
(T2D)
patients,
order
provide
scientific
evidence
for
prevention
treatment
macrovascular
complications
T2D.
Patients
Methods:
This
research
adopts
cross-sectional
design.
Anthropometric
assessment,
baPWV
assessment
biochemical
were
performed
2906
T2D
patients.
CVAI
was
calculated
from
combination
triglycerides,
age,
high-density
lipoprotein
cholesterol,
waist
circumference,
body
mass
index.
Multivariate
regression
analysis
generalized
additive
model
used
analyze
bapwv
CVAI.
Subgroup
interaction
influencing
factors.
Results:
After
adjustment
covariates,
tended
increase
quartiles
In
males,
As
increases
by
a
unit,
increased
0.28
cm/s
(95%
CI:
−
0.05,
0.61
P=0.0934).
females,
1.60
1.07,
2.14).
A
non-linear
connection
males
linear
females
revealed.
we
found
that
interacted
with
different
duration
(P
=
0.0052),
alcohol
consumption
status
0.0375).
glycated
hemoglobin
0.0003),
systolic
blood
pressure
0.0001),
diastolic
interaction<
0.0014),
use
or
non-use
glucose-lowering
drugs
0.0006),
antihypertensive
0.0004),
females'
menopausal
0.0012).
Conclusion:
relationship
patients
positively
females.
all
subjects,
influenced
duration.
drinking
affected
relationship,
It
pressure,
glycemic
control,
status,
hypotensive
drug,
highlighting
complex
interplay
visceral
fat
arterial
stiffness
population.
Keywords:
adipose
index,
stiffness,
BMC Endocrine Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 18, 2024
Abstract
Objective
Infertility
is
associated
with
obesity.
The
Body
Roundness
Index
(BRI)
a
body
measurement
index
related
to
obesity
that
more
accurately
assesses
and
visceral
fat
levels.
However,
the
relationship
between
BRI
infertility
remains
unclear.
Therefore,
this
study
aims
determine
infertility.
Methods
This
utilized
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2013
2018
included
3,528
women
aged
18–45
years.
Multivariate
logistic
regression
was
employed
investigate
association
Restricted
cubic
spline
(RCS)
analysis
explored
linear
or
non-linear
Interaction
analyses
were
conducted
on
subgroups
validate
findings.
To
verify
robustness
of
results,
we
performed
several
sensitivity
analyses,
including
propensity
score
matching(PSM)
multiple
imputations
for
missing
data.
Furthermore,
predictive
capabilities
various
anthropometric
indices—including
BRI,
weight-adjusted
waist
(WWI),
mass
(BMI),
weight—on
incidence
assessed
using
Receiver
Operating
Characteristic
(ROC)
curve
analysis.
Results
There
significant
positive
After
adjusting
covariates,
each
unit
increase
in
there
12%
probability
(
P
<
0.001).
correlation
persisted
when
categorized
into
quartiles.
Moreover,
as
increased,
trend
towards
higher
prevalence
dose-response
indicated
infertility,
risk.
subgroup
imputations.
ROC
revealed
had
superior
capability
compared
traditional
indices,
an
area
under
(AUC)
0.618
(95%
CI,
0.588–0.648).
Conclusion
results
show
strong
Clinical
trial
number
Not
Applicable.
