Lifestyle Modification in Prediabetes and Diabetes: A Large Population Analysis DOI Open Access

Michael L. Dansinger,

Joi A. Gleason,

Julia Maddalena

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1333 - 1333

Опубликована: Апрель 11, 2025

Background/Aims: Diabetes mellitus is a major cause of atherosclerotic cardiovascular disease (ASCVD). We examined large population and tested the efficacy voluntary lifestyle program in prediabetic diabetic subjects. Methods: Of 133,764 subjects, 56.3% were healthy, 36.2% prediabetic, 7.5% diabetic. Fasting serum measurements glucose, insulin, adiponectin, glycosylated hemoglobin (HbA1c), high-sensitivity C-reactive protein (hs-CRP), glycated (GSP), fibrinogen, myeloperoxidase (MPO), lipoprotein-associated phospholipase A2 (LpPLA2), as well standard lipids, direct low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C) performed using automated assays. Follow-up sampling at 6–12 months occurred 20.1% 22.2% subjects; these, 12.2% 9.7% subjects participated voluntary, real-world, digital dietitian-directed lifestyle-modification with 10-year diabetes risk being calculated biochemical model (Framingham). Results: Prediabetic had significantly elevated triglycerides, sdLDL-C, hs-CRP decreased HDL-C. They insulin resistant compared to healthy but only diabetics significant reductions production. Lifestyle modification reduced by 45.6% prediabetics increased (2.4-fold) percentage that remission follow-up (8.2% versus 3.4%) weight loss (6.5 2.0 pounds). intervention resulted favorable effects on many metabolic markers. Conclusions: The measurement fasting glucose essential for detection production diabetics. A can have ASCVD factors status.

Язык: Английский

Lifestyle Modification in Prediabetes and Diabetes: A Large Population Analysis DOI Open Access

Michael L. Dansinger,

Joi A. Gleason,

Julia Maddalena

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1333 - 1333

Опубликована: Апрель 11, 2025

Background/Aims: Diabetes mellitus is a major cause of atherosclerotic cardiovascular disease (ASCVD). We examined large population and tested the efficacy voluntary lifestyle program in prediabetic diabetic subjects. Methods: Of 133,764 subjects, 56.3% were healthy, 36.2% prediabetic, 7.5% diabetic. Fasting serum measurements glucose, insulin, adiponectin, glycosylated hemoglobin (HbA1c), high-sensitivity C-reactive protein (hs-CRP), glycated (GSP), fibrinogen, myeloperoxidase (MPO), lipoprotein-associated phospholipase A2 (LpPLA2), as well standard lipids, direct low-density lipoprotein cholesterol (LDL-C), small dense LDL-C (sdLDL-C) performed using automated assays. Follow-up sampling at 6–12 months occurred 20.1% 22.2% subjects; these, 12.2% 9.7% subjects participated voluntary, real-world, digital dietitian-directed lifestyle-modification with 10-year diabetes risk being calculated biochemical model (Framingham). Results: Prediabetic had significantly elevated triglycerides, sdLDL-C, hs-CRP decreased HDL-C. They insulin resistant compared to healthy but only diabetics significant reductions production. Lifestyle modification reduced by 45.6% prediabetics increased (2.4-fold) percentage that remission follow-up (8.2% versus 3.4%) weight loss (6.5 2.0 pounds). intervention resulted favorable effects on many metabolic markers. Conclusions: The measurement fasting glucose essential for detection production diabetics. A can have ASCVD factors status.

Язык: Английский

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