Osteonecrosis of the femoral head in post-COVID-19 patients: a retrospective comparative study

Journal of Orthopaedic Surgery and Research, Год журнала: 2025, Номер 20(1)

Опубликована: Апрель 10, 2025

Abstract Background The COVID-19 pandemic has claimed many lives and continues to impact individuals through post-COVID-19 conditions. Osteonecrosis of the femoral head (ONFH) is increasingly recognized as a major complication, yet most studies are limited case reports small series. This study aimed evaluate COVID-19-related factors potentially contributing ONFH development in patients. Methods A retrospective analysis was conducted on 84 patients with confirmed history COVID-19. Baseline characteristics were collected, categorized into following groups for comparative analysis: (1) vaccinated vs. unvaccinated, (2) unilateral bilateral ONFH, (3) dexamethasone (DEX) methylprednisolone (MPS) DEX therapy, (4) Association Research Circulation Osseus (ARCO) stage 2 3. Group differences associations analyzed. Results MPS-treated group had greater extent lung involvement compared DEX-treated (59.2% 36.3%, p = 0.002), well longer hospital stays both general ward (14.2 days 10.6 days, 0.018) ICU (5.4 3 0.017). also duration steroid therapy (19.3 12.3 < 0.001) received higher DEX-equivalent cumulative doses (380 mg 125 mg, 0.001). Notably, symptoms developed earlier (7.5 months 12 months, 0.004). Multivariable logistic regression identified dose sole predictor severity (OR: 1.015, 95% CI: 1.001–1.028, 0.032), ARCO receiving than (240 126 0.018). Conclusions Our demonstrated that primary determinant Additionally, combined use corticosteroids may accelerate onset highlighting need cautious management

Язык: Английский

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Calcified Cartilage Zone Remodeling Induced by IL-1β Derived from Necrotic Subchondral Bone Initiates Cartilage Degeneration in Patients with Glucocorticoids-induced Osteonecrosis of the Femoral Head

Inflammation, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

Язык: Английский

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OSTEONECROSIS: A DISABLING DISEASE NOT TO BE IGNORED IN ASTHMA AND ATOPIC CONDITIONS

Annals of Allergy Asthma & Immunology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Язык: Английский

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Comparing Modified Light Bulb with Multiple Drilling Methods in Treating Non-Traumatic Femoral Head Osteonecrosis: A Cohort Study

Journal of Orthopaedic Reports, Год журнала: 2024, Номер unknown, С. 100503 - 100503

Опубликована: Окт. 1, 2024

Язык: Английский

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