Magnetic Resonance Enterography and Intestinal Ultrasound for the Assessment and Monitoring of Crohn’s Disease

Journal of Crohn s and Colitis, Год журнала: 2024, Номер 18(9), С. 1450 - 1463

Опубликована: Март 30, 2024

Magnetic resonance enterography [MRE] and intestinal ultrasound [IUS] have developed rapidly in the past few decades, emerging as primary non-invasive options for both diagnosing monitoring Crohn's disease [CD]. In this review, we evaluate pertinent data relating to use of MRE IUS CD. We summarise key imaging features CD activity, highlight their increasing role clinical research settings, discuss how these modalities fit within diagnostic pathway. they can be used assess activity treatment responsiveness, including emergence scores standardised reporting. Additionally, address areas controversy such contrast agents, diffusion-weighted imaging, point-of-care ultrasound. also exciting new developments, applications artificial intelligence. Finally, provide suggestions future priorities.

Язык: Английский

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Investigating Whether Dissemination in Time Is Essential to Diagnose Relapsing Multiple Sclerosis

Neurology, Год журнала: 2025, Номер 104(7)

Опубликована: Март 4, 2025

The diagnosis of multiple sclerosis (MS) requires evidence both dissemination in space (DIS) and time (DIT); oligoclonal bands (OCBs) the CSF can substitute for DIT on MRI. We investigated whether (or positive CSF) is necessary to make a MS patients who fulfil high number DIS criteria. prospectively recruited with first demyelinating event evaluated brain spinal cord MRI within 3 months onset. were followed up clinically retrospectively applied criteria requiring lesions ≥2/4, ≥3/4, or 4/4 regions typically affected (periventricular, cortical/juxtacortical, infratentorial, cord) ≥2/5, ≥3/5, ≥4/5, 5/5 (including optic nerve) baseline assessments. performance each set using 2017 McDonald criteria, (lesions ≥2/4 regions) plus (gadolinium-enhancing nonenhancing lesions, new T2 at follow-up) CSF-specific OCBs, as gold standard. included 244 (mean age 32.5 years, 154 [63%] female); 187 (77%) diagnosed over mean follow-up 11.2 years. alone, regions, exhibited reducing sensitivity (84%, 58%, 26%, respectively) increasing specificity (91%, 98%, 100%) an diagnosis. In 112 (46%) nerve assessment orbital visual evoked potentials, also resulted (96%, 83%, 61%, 30%) (44%, 100%, propose diagnostic algorithm based fulfilled. event, ≥4 highly specific, indicating extremely low risk false-positive results, misdiagnosis. Using would reduce need examination all suspected MS, streamlining process. Limitations include over-representation neuritis onset, rate examination, lack optical coherence tomography data.

Язык: Английский

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Advances in image‐based diagnosis of nail disorders

Journal of the European Academy of Dermatology and Venereology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 4, 2024

Abstract This paper provides a comprehensive overview of image‐based techniques, particularly focusing on their applications and advancements in the context nail disorders. Nowadays, high‐resolution digital cameras dermoscopes enable dermatologists to capture detailed images abnormalities, facilitating early diagnosis meticulous tracking disease progression. Onychoscopy is now routine technique with well‐known criteria for diagnosis, but recent developments allow us visualize certain diseases better. Imaging modalities like high‐frequency ultrasound, magnetic resonance imaging, optical coherence tomography confocal microscopy are being increasingly adopted superior diagnostic capabilities. These techniques described technology, scanning protocols, normal findings, advantages limitations. Moreover, integration technology patient education has fostered more informed population, capable actively participating monitoring treatment regimens. Proper training, validation, regulation ethical considerations are, however, essential when integrating into healthcare practices. technologies that present potential add critical anatomical information clinical diagnoses within reasonable costs available worldwide ones will probably be used most.

Язык: Английский

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Identification of key elements in MRI reporting of intracranial meningiomas based on a nationwide survey of clinical experts in Germany

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 7, 2025

Язык: Английский

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Gadopiclenol Enables Reduced Gadolinium Dose While Maintaining Quality of Pulmonary Arterial Enhancement for Pulmonary MRA

Investigative Radiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Rationale and Objectives Pulmonary magnetic resonance angiography (MRA) is an imaging method with proven utility for the exclusion of pulmonary embolism avoids need ionizing radiation iodinated contrast agents. High-relaxivity gadolinium-based agents (GBCAs), such as gadopiclenol, can be used to reduce required gadolinium dose MRA. The aim this study was compare enhancement performance gadopiclenol established gadobenate dimeglumine–enhanced MRA protocol. Materials Methods In retrospective single-center study, data from 152 patients who underwent at 1.5 T were analyzed. Imaging performed either 0.05 mmol/kg (n = 75) or 0.1 dimeglumine 77), using dedicated multiphasic protocols precontrast, arterial phase, immediate delayed a low flip-angle T1-weighted spoiled gradient echo acquisition. Subjective image quality evaluation blinded by 2 radiologists on 5-point Likert scale. For estimation interrater reliability, Cohen weighted κ calculated. semiquantitative assessment, signal intensities measured in arteries, relative Data groups compared Mann-Whitney U tests Bonferroni corrections. Results Signal precontrast first-pass phase higher (20.0-fold ± 5.6-fold vs 17.8-fold 5.8-fold; P 0.015). Readers observed no difference subjective rating terms intravascular contrast, peripheral vessel depiction, diagnostic confidence substantial reliability (Cohen 0.73 [95% interval: 0.57–0.89], 0.65 [0.55–0.75], 0.74 [0.65–0.84], all 's < 0.001). No severe adverse events recorded any clinical examination. Conclusions high-relaxivity agent facilitate reduction 50% without compromising This approach may enhance safety sustainability long term.

Язык: Английский

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Sub-1-min relaxation-enhanced non-contrast non-triggered cervical MRA using compressed SENSE with deep learning reconstruction in healthy volunteers

European Radiology Experimental, Год журнала: 2025, Номер 9(1)

Опубликована: Фев. 18, 2025

Abstract Background We evaluated the acceleration of a three-dimensional isotropic flow-independent magnetic resonance angiography (MRA) (relaxation-enhanced without contrast and triggering, REACT) neck arteries using compressed SENSE (CS) combined with deep learning (adaptive intelligence, AI)-based reconstruction (CS-AI). Methods Thirty-four volunteers received 3-T REACT MRA, acquired threefold: (i) CS factor 7 (CS7), scan time 1:20 min:s; (ii) 10 (CS10), 0:55 (iii) CS-AI (CS10-AI), min:s. Two radiologists rated image quality seven arterial segments overall noise. Additionally, pairwise forced-choice comparison was conducted. Apparent signal-to-noise ratio (aSNR) contrast-to-noise (aCNR) were measured, sharpness assessed edge-rise distance (ERD). Multiple t -tests nonparametric tests Bonferroni correction performed for to CS7 as reference standard. Results Compared CS7, CS10 showed lower ( p < 0.001) while CS10-AI obtained higher scores = 0.010). Image noise similar between 0.138) yielded 0.008). Forced choice revealed preferences over 0.001), but no preference > 0.999). aSNR aCNR in ERD longer 0.004), provided better difference 0.776). Conclusion Sub-1-min cervical MRA compromising quality. Relevance statement The implementation fast reliable non-contrast has potential reduce costs increasing patient comfort safety. Clinical studies evaluating diagnostic performance stenosis or dissection are needed. Trial registration DRKS00030210 (German Trials Register; https://drks.de/ ) Key Points Deep enables sub-1-min non-contrast-enhanced extracranial arteries. Acceleration causes inferior exceeds, part, clinical Graphical abstract

Язык: Английский

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A General Overview of Transthyretin Cardiac Amyloidosis and Summary of Expert Opinions on Pre-Symptomatic Testing and Management of Asymptomatic Patients with a Focus on Transthyretin V122I

Hearts, Год журнала: 2025, Номер 6(1), С. 6 - 6

Опубликована: Фев. 26, 2025

Transthyretin cardiac amyloidosis (TTR-CA) is a pathological condition characterized by the accumulation of misfolded transthyretin (TTR) protein in heart, leading to restrictive cardiomyopathy. TTR-CA has gained increasing recognition recent years due its significant impact on morbidity and mortality. It typically diagnosed when symptoms heart failure appear. However, with advancements non-invasive imaging, early precise diagnosis now possible, enabling clinicians take advantage current therapeutic interventions that are more effective initiated at an earlier stage disease. Moreover, genetic testing can assist identifying asymptomatic individuals who risk developing disease before clinical features manifest. In this review, we provide general overview summarize expert opinions pre-symptomatic management patients, particular focus V122I mutation. This article aims better understanding best practices for managing patients predisposition.

Язык: Английский

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Diagnostic Accuracy of Non-Contrast Magnetic Resonance Imaging in Diagnosing Pituitary Micro-Adenoma, Taking Histopathology as Gold Standard

Pakistan Journal of Medicine and Dentistry, Год журнала: 2025, Номер 14(1), С. 74 - 80

Опубликована: Янв. 10, 2025

Background: Pituitary microadenomas (PMs) are common benign tumors that often not visualized even when they present due to their asymptomatic nature. The objective of the study was evaluate diagnostic accuracy non-contrast magnetic resonance imaging (MRI) in diagnosis pituitary using histopathology as a gold standard. Methods: This cross-sectional validation (IRB Approval No. IRB/18/2024/01) included 121 patients presenting with severe headaches and focal brain lesions on CT scans at Doctors Hospital, Lahore from September 2024 November 2024. In this study, non-probability consecutive sampling technique used. A standardized protocol used for MRI findings were interpreted by experienced radiologists. comparison made against reference 2×2 contingency table calculate sensitivity, specificity, positive predictive value negative value, overall SPSS version 25. Results: Of (mean age 40.74 ± 10.35 years), 70 (57.9%) females. Non-contrast showed sensitivity specificity 37.25% (38/102) 89.47% (17/19) respectively. Specificity is high, meaning modality reliable eliminating false positives, but low, which means it won’t find true positives correctly. percentage 45.5% (55/121) had room significant improvement. Conclusion: can be clinicopathologically screened an initial radiation-free minimal ionizing contrast agents-based risk being valuable long-term monitoring.

Язык: Английский

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Gadolinium-based MRI contrast agent effects on calcium signaling and actin-dependent cell functions.

Опубликована: Фев. 1, 2025

Язык: Английский

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Diagnostic Impact of DWI Absence on Prostate Lesion Assessment using PI-RADS 2.1

Current Problems in Diagnostic Radiology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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