Multiparametric MRI Radiomics With Machine Learning for Differentiating HER2-Zero, -Low, and -Positive Breast Cancer: Model Development, Testing, and Interpretability Analysis

American Journal of Roentgenology, Год журнала: 2024, Номер 224(1)

Опубликована: Окт. 16, 2024

BACKGROUND. MRI radiomics has been explored for three-tiered classification of HER2 expression levels (i.e., HER2-zero, HER2-low, or HER2-positive) in patients with breast cancer, although an understanding how such models reach their predictions is lacking. OBJECTIVE. The purpose this study was to develop and test multiparametric machine learning differentiating as well explain the contributions model features through local global interpretations use Shapley additive explanation (SHAP) analysis. METHODS. This retrospective included 737 (mean age, 54.1 ± 10.6 [SD] years) cancer from two centers (center 1 [n = 578] center 2 159]), all whom underwent had determined after excisional biopsy. Analysis entailed tasks: HER2-negative HER2-zero HER2-low) tumors HER2-positive (task 1) HER2-low 2). For each task, were randomly assigned a 7:3 ratio training set 1: n 405; task 2: 284) internal 173; 122); formed external 159; 105). Radiomic extracted early phase dynamic contrast-enhanced (DCE) imaging, T2-weighted DWI. support vector (SVM) used feature selection, score (radscore) computed using weights SVM correlation coefficients, conventional combined constructed, performances evaluated. SHAP analysis provide outputs. RESULTS. In set, 1, AUCs model, radscore, 0.624, 0.757, 0.762, respectively; 2, AUC radscore 0.754, no could be constructed. identified DCE imaging having strongest influence both tasks; also prominent role 2. CONCLUSION. findings indicate suboptimal performance noninvasive characterization expression. CLINICAL IMPACT. provides example interpretation better understand imaging-based models.

Язык: Английский

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Quantification of intratumoral heterogeneity using habitat-based MRI radiomics to identify HER2-positive, -low and -zero breast cancers: a multicenter study

Breast Cancer Research, Год журнала: 2024, Номер 26(1)

Опубликована: Ноя. 22, 2024

Human epidermal growth factor receptor 2-targeted (HER2) therapy with antibody-drug conjugates has proven effective for patients HER2-low breast cancer. However, intratumoral heterogeneity (ITH) poses a great challenge in identifying tumors. ITH signatures were developed by quantifying to differentiate HER2-positive, -low and -zero cancers. This retrospective study included 614 from two institutions. The was structured into primary tasks: task 1 between HER2-positive -negative tumors, followed 2 Whole-tumor radiomics features habitat extracted MRI construct the signatures. Multivariable logistic regression analysis used determine significant independent predictors. A combined model integrating clinicopathologic variables, signature, signature (1) Subsequently, better-performing established using same approach (2) area under receiver operating characteristic curve (AUC) assess performance of each model. Task comprised (training, n = 348; validation, 149; test cohorts, 117). encompassed 501 283; 122; 96). For task1, showed outstanding performance, achieving AUCs 0.81, 0.81 training, validation respectively. achieved improved 0.83, 0.84 0.83 across three task2, maintained superior 0.94, 0.93 indicated that none characteristics retained as predictors associated odds Our quantified habitat-based radiomics, differentiating HER2-postive further

Язык: Английский

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Preoperative diagnosis of meningioma sinus invasion based on MRI radiomics and deep learning: a multicenter study

Cancer Imaging, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 28, 2025

Abstract Objective Exploring the construction of a fusion model that combines radiomics and deep learning (DL) features is great significance for precise preoperative diagnosis meningioma sinus invasion. Materials methods This study retrospectively collected data from 601 patients with confirmed by surgical pathology. For each patient, 3948 features, 12,288 VGG 6144 ResNet 3072 DenseNet were extracted MRI images. Thus, univariate logistic regression, correlation analysis, Boruta algorithm applied further feature dimension reduction, selecting DL highly associated Finally, models constructed using random forest (RF) algorithm. Additionally, diagnostic performance different was evaluated receiver operating characteristic (ROC) curves, AUC values compared DeLong test. Results Ultimately, 21 invasion selected, including 6 2 7 features. Based on these five constructed: model, DL-radiomics (DLR) model. demonstrated superior performance, 0.818, 0.814, 0.769 in training set, internal validation independent external respectively. Furthermore, results test indicated there significant differences between both ( p < 0.05). Conclusions The combining exhibits It expected to become powerful tool clinical plan selection patient prognosis assessment.

Язык: Английский

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Dual-Modality Virtual Biopsy System Integrating MRI and MG for Noninvasive Predicting HER2 Status in Breast Cancer

Academic Radiology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Multi-parametric MRI Radiomics Predicts Different HER2 Expression in Breast Cancer

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Purpose To develop and validate radiomic models using multi-parametric dynamic contrast-enhanced MRI (DCE-MRI) intravoxel incoherent movement (IVIM)-based features for the preoperative differentiation of HER2 expressions levels in breast cancer.Materials Methods This retrospectively study analyzed 227 female cancer patients who underwent 3.0TMRI examination at our institution from December 2019 to 2023. The least absolute shrinkage selection operator (LASSO) ten-fold cross-validation method was used identify positive negative cancer(task 1), further low zero 2). Then were selected combined with clinical characteristics construct predicting logistic regression analysis. area under receiver operating characteristic curve(AUC), sensitivity, specificity evaluate performance models.Results For task 1, AUCs model (histological grade peritumoral edema), DCE IVIM(D + D*+f) clinic 0.785 (95%CI:0.713,0.846), 0.866 (95%CI:0.803,0.915) 0.903 (95%CI:0.846,0.944) respectively. In validation cohort, 0.751 (95%CI:0.633,0.848), (95%CI:0.633,0.848) 0.830 (95%CI:0.720,0.910) 2, IVIM training cohort 0.951 (95%CI:0.888,0.984) 0.853 (95%CI:0.712,0.942) respectively, radiomics score independent predictors cancer.Conclusion signature derived MRI, together edema histological grade, demonstrated strong expression preoperatively cancer, which may support individualized treatment strategies.

Язык: Английский

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MRI-based habitat analysis for Intratumoral heterogeneity quantification combined with deep learning for HER2 status prediction in breast cancer

Magnetic Resonance Imaging, Год журнала: 2025, Номер unknown, С. 110429 - 110429

Опубликована: Май 1, 2025

Язык: Английский

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CT Radiomics for Predicting Outcomes in HER2-Positive Surgically Resectable Advanced Gastric Cancer: A Preliminary Study

Academic Radiology, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

Язык: Английский

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Preoperative prediction of HER2 expression and sentinel lymph node status in breast cancer using a mammography radiomics model

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Июнь 4, 2025

Background This study aimed to develop and validate radiomic features derived from mammography (MG) differentiate between various HER2 expression types (HER2-positive, HER2-low, HER2-zero) preoperatively assess sentinel lymph node (SLN) status in breast cancer. Methods A retrospective analysis was conducted using clinicopathological imaging data 838 female cancer patients diagnosed at the Affiliated Tumor Hospital of Xinjiang Medical University January 2016 September 2024. The were randomly divided into a training set (n=586) test (n=252) 7:3 ratio. Multivariate logistic regression identified independent clinical predictors. segmentation feature extraction performed on images. least absolute shrinkage selection operator (LASSO) method applied for selection, radiomics model developed. Model performance assessed area under receiver operating characteristic curve (AUC), calibration curve, decision analysis. Results There no significant differences factors mammographic sets (P&gt;0.05). ethnicity, lesion size, vascular tumor thrombus, stage, margin, as predictors SLN metastasis. Lesion PR expression, menopausal status, metastasis, Ki67, CK5/6 calcification expression. metastasis prediction achieved AUCs 0.84 0.83 set. showed 0.87 (positive), 0.82 (low), 0.85 (zero) set, 0.78 Conclusion Radiomic based can effectively predict cancer, offering valuable insights individualized treatment strategies.

Язык: Английский

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Development and Validation of a Deep Learning System to Differentiate HER2‐Zero, HER2‐Low, and HER2‐Positive Breast Cancer Based on Dynamic Contrast‐Enhanced MRI

Journal of Magnetic Resonance Imaging, Год журнала: 2024, Номер unknown

Опубликована: Дек. 6, 2024

Background Previous studies explored MRI‐based radiomic features for differentiating between human epidermal growth factor receptor 2 (HER2)‐zero, HER2‐low, and HER2‐positive breast cancer, but deep learning's effectiveness is uncertain. Purpose This study aims to develop validate a learning system using dynamic contrast‐enhanced MRI (DCE‐MRI) automated tumor segmentation classification of HER2‐zero, statuses. Study Type Retrospective. Population One thousand two hundred ninety‐four cancer patients from three centers who underwent DCE‐MRI before surgery were included in the (52 ± 11 years, 811/204/279 training/internal testing/external testing). Field Strength/Sequence 3 T scanners, T1‐weighted 3D fast spoiled gradient‐echo sequence, enhanced sequence turbo field echo sequence. Assessment An model segmented tumors utilizing data, followed by models (ResNetGN) trained classify HER2 Three developed distinguish their respective non‐HER2 categories. Statistical Tests Dice similarity coefficient (DSC) was used evaluate performance model. Evaluation performances statuses involved receiver operating characteristic (ROC) curve analysis area under (AUC), accuracy, sensitivity, specificity. The P ‐values <0.05 considered statistically significant. Results automatic network achieved DSC values 0.85 0.90 compared manual across different sets. ResNetGN AUCs 0.782, 0.776, 0.768 HER2‐zero others training, internal test, external test sets, respectively. Similarly, 0.820, 0.813, 0.787 HER2‐low vs. others, 0.792, 0.745, 0.781 Data Conclusion proposed DCE‐MRI‐based may have potential preoperatively distinct expressions cancers with therapeutic implications. Evidence Level 4 Technical Efficacy Stage

Язык: Английский

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A Comprehensive Model Outperformed the Single Radiomics Model in Noninvasively Predicting the HER2 Status in Patients with Breast Cancer

Academic Radiology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Язык: Английский

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