Post-translational histone modifications associated with the development of metabolic dysfunction-associated fatty liver disease. Part 1. General provisions
GASTROENTEROLOGY,
Год журнала:
2024,
Номер
58(3), С. 210 - 221
Опубликована: Сен. 13, 2024
Based
on
the
analysis
of
literary
sources
PubMed,
MedLine,
The
Cochrane
Library,
EMBASE
database,
authors
article
give
general
provisions
regarding
post-translational
modifications
histones
(small
proteins
with
a
molecular
weight
10–15
kDa,
which
make
up
largest
part
nuclear
proteins),
are
associated
development
metabolic
dysfunction-associated
fatty
liver
disease.
emphasize
that
histone
regulate
activity
gene
expression,
and
each
these
types
differently
changes
structure
chromatin
and,
as
result,
expression.
Currently,
more
than
20
protein
have
been
identified
(acetylation,
biotinylation,
butyrylation,
2-hydroxybutyrylation,
ADP-ribosylation,
N-formylation,
hydroxylation,
glycosylation,
glutarylation,
dopaminylation,
proline
isomerization
aspartic
acid
carbonylation,
crotonylation,
lactylation,
malonylation,
methylation,
propionylation,
succinylation,
SUMOylation,
ubiquitination,
phosphorylation,
citrullination).
Epigenetic
epitranscriptomic
induced
by
lifestyle,
especially
nature
diet
physical
activity,
influence
exogenous
endogenous
factors.
Prolonged
epigenetic
determine
expression
target
genes
can
be
accompanied
disorders
progression
Histone
modification
is
carried
out
site-specific
enzymes:
writers,
identify
marker,
erasers,
“erase”
marker.
Post-translational
change
local
physicochemical
environment
based
this,
directly
affect
nucleosome
chromatin.
Also,
N-
C-terminal
tails
act
“docking
sites”
recruit
specific
readers.
Readers
both
in
intranucleosomal
space,
modifying
adjacent
sites
or
recruiting
transcription
factors,
activators
repressors,
internucleosomal
space.
also
describe
pathophysiological
significance
disease,
diagnostic
value
biomarkers,
potential
pharmacological
management
to
achieve
inhibition
pathological
process.
Язык: Английский
Clinical epidemiology of metabolic-associated fatty liver disease in overweight and obese children
CHILD`S HEALTH,
Год журнала:
2024,
Номер
19(5), С. 253 - 258
Опубликована: Сен. 24, 2024
Background.
Metabolic-associated
fatty
liver
disease
(MAFLD)
is
one
of
the
leading
causes
chronic
diseases
in
overweight/obese
children.
The
aim
was
to
study
frequency
MAFLD
and
identify
risk
factors
that
are
potentially
associated
with
this
Materials
methods.
conducted
2020–2023.
Inclusion
criteria
were
body
mass
index
>
85th
percentile
for
age/gender,
child’s
age
from
6
18
years.
We
used
screening
diagnose
MAFLD:
an
increased
level
alanine
aminotransferase
(ALT)
80
U/L
at
first
visit,
or
a
persistently
elevated
(>
3
months)
ALT
twice
upper
limit
normal
(in
girls,
≥
44
U/L,
boys,
52
U/L).
At
second
stage
study,
we
analysed
MAFLD.
All
stages
work
carried
out
taking
into
account
bioethical
norms
Declaration
Helsinki.
Results.
common
metabolic
condition
children
its
studied
cohort
22
%.
development
following
factors:
male
gender
(odds
ratio
(OR)
=
2.06),
intrauterine
growth
restriction
(OR
4.09),
formula
feeding
2.54),
family
history
type
2
diabetes
2.55),
high
consumption
foods
rich
carbohydrates
3.31),
sedentary
lifestyle
10.16),
obesity
48.15),
prehypertension
4.41),
prediabetes/type
2.37),
vitamin
D
deficiency
2.40).
Conclusions.
inclusion
above-mentioned
algorithm
will
help
early
detection,
treatment
prevention
cohort.
Язык: Английский