POTENTIAL FOR DIABETIC WOUND HEALING WITH HYDROGEL PATCH OF NEEM LEAF EXTRACT (AZADIRACHTA INDICA) DOI Open Access
Nurdiyah Lestari,

DISKI W. WIJIANTO,

Arifah Sri Wahyuni

и другие.

International Journal of Applied Pharmaceutics, Год журнала: 2025, Номер unknown, С. 250 - 258

Опубликована: Март 7, 2025

Objective: Disruptions in the wound healing process occur because of two main factors diabetes: high blood sugar levels and chronic inflammation. This study evaluated effectiveness hydrogel patches containing neem leaf extract diabetic wounds. Methods: The experimental method used a post-test control group design that included preparation, phytochemical screening, patch stability testing, testing hyperglycemic rats by observing size, histopathology, TNF-α TGF-β cytokine on days 7, 14, 21. Results: contains secondary metabolites support anti-inflammatory wound-healing activities. Stability tests showed met standards for organoleptic properties, weight uniformity, moisture absorption. given NLEHP (Neem Leaf Extract Hydrogel Patch) decrease area (0.5±0.1 cm2) not significantly different from non-diabetic with reduction (p>0.05) negative (1.1±0 (p<0.05). Histopathological analysis skin thickness (19.2±1.6 μm) was (18.2±0.8 higher than (10.7±2.4 significant increase (p<0.05) group, whereas groups non-significant (p>0.05). progressively increased groups, unlike decline observed control. Conclusion: These results indicate is an effective alternative therapy.

Язык: Английский

POTENTIAL FOR DIABETIC WOUND HEALING WITH HYDROGEL PATCH OF NEEM LEAF EXTRACT (AZADIRACHTA INDICA) DOI Open Access
Nurdiyah Lestari,

DISKI W. WIJIANTO,

Arifah Sri Wahyuni

и другие.

International Journal of Applied Pharmaceutics, Год журнала: 2025, Номер unknown, С. 250 - 258

Опубликована: Март 7, 2025

Objective: Disruptions in the wound healing process occur because of two main factors diabetes: high blood sugar levels and chronic inflammation. This study evaluated effectiveness hydrogel patches containing neem leaf extract diabetic wounds. Methods: The experimental method used a post-test control group design that included preparation, phytochemical screening, patch stability testing, testing hyperglycemic rats by observing size, histopathology, TNF-α TGF-β cytokine on days 7, 14, 21. Results: contains secondary metabolites support anti-inflammatory wound-healing activities. Stability tests showed met standards for organoleptic properties, weight uniformity, moisture absorption. given NLEHP (Neem Leaf Extract Hydrogel Patch) decrease area (0.5±0.1 cm2) not significantly different from non-diabetic with reduction (p>0.05) negative (1.1±0 (p<0.05). Histopathological analysis skin thickness (19.2±1.6 μm) was (18.2±0.8 higher than (10.7±2.4 significant increase (p<0.05) group, whereas groups non-significant (p>0.05). progressively increased groups, unlike decline observed control. Conclusion: These results indicate is an effective alternative therapy.

Язык: Английский

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