Development of a Multifaceted Program for Pharmacogenetics Adoption at an Academic Medical Center: Practical Considerations and Lessons Learned

Clinical Pharmacology & Therapeutics, Год журнала: 2024, Номер 116(4), С. 914 - 931

Опубликована: Авг. 21, 2024

In 2019, Indiana University launched the Precision Health Initiative to enhance institutional adoption of precision medicine, including pharmacogenetics (PGx) implementation, at university‐affiliated practice sites across Indiana. The overarching goal this PGx implementation program was facilitate sustainable genotype‐guided prescribing into routine clinical care. To accomplish goal, we pursued following specific objectives: (i) integrate testing existing healthcare system processes; (ii) implement drug–gene pairs with high‐level evidence and educate providers pharmacists on established management recommendations; (iii) engage key stakeholders, patients optimize return results for testing; (iv) reduce health disparities through targeted inclusion underrepresented populations; (v) track third‐party reimbursement. This tutorial details our multifaceted program, descriptions interventions, critical challenges faced, major successes. By describing experience, aim assist other teams in achieving their systems.

Язык: Английский

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Pharmacogenetic testing in primary care could bolster depression treatment: A value proposition

Clinical and Translational Science, Год журнала: 2024, Номер 17(6)

Опубликована: Июнь 1, 2024

Abstract Pharmacogenetic testing could reduce the time to identify a safe and effective medication for depression; however, it is underutilized in practice. Major depression constitutes most common mental disorder US, while antidepressant therapy can help, current trial –and error approach require patients endure multiple trials before finding one that effective. Tailoring fit of pharmacogenetic with prescribers' needs across variety settings help establish generalizable value proposition improve likelihood adoption. We conducted study explore health systems using medications through real‐world experiences implementation science concepts systematic interviews prescribers administrators from four care systems. To proposition, we organized themes according Triple Aim framework, leading framework policy which asserts high‐value should focus on three key metrics: (1) better quality (2) population‐level outcomes (3) reduced per capita costs. Primary providers whom interviewed said they because would provide more information about prescribe, expanding their ability best‐fit reducing reliance referrals specialists; this capacity meet patients' access primary care. At same time, expressed differing views how whether out‐of‐pocket cost prevent them offering it. Thus, integrating into strategies support interactions patients.

Язык: Английский

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A qualitative approach to assess the opinion of physicians about the challenges and prospects of pharmacogenomic testing implementation in clinical practice in Greece

Human Genomics, Год журнала: 2024, Номер 18(1)

Опубликована: Июль 19, 2024

Abstract Background Pharmacogenomics (PGx) constitutes an important part of personalized medicine and has several clinical applications. PGx role in practice is known, however, it not been widely adopted yet. In this study, we aim to investigate the perspectives Greek physicians regarding implementation testing key issues associated with it. Methods Fourteen interviews were conducted various specialties for which applications are available. A semi-structured interview guide was utilized based on Consolidated Framework Implementation Research (CFIR) context Diffusion Innovation model. Transcripts coded independently compared by two members research team. Descriptive statistics generated using Microsoft Excel. Results Six main themes emerged: awareness use testing; source information; stakeholders supply chain, their interactions change agents; benefit significance barriers lack reimbursement; recommendations boost adoption rate. Most respondents aware applications, but only three had already recommended testing. Peer-reviewed journals along guidelines regarded as most used information while chain discussed. considered that promote patient-centered care, enhance medication effectiveness, decrease risk side effects, reduce healthcare costs. Lack reimbursement, scarcity resources, high cost foremost affecting adoption. Conclusions It concluded if case reimbursed physicians’ training reinforced, will be boosted improved shortly.

Язык: Английский

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A qualitative approach to assess the opinion of physicians about the challenges and future prospects of pharmacogenomic testing implementation in clinical practice.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 17, 2024

Background: Pharmacogenomics (PGx) constitutes an important part of personalized medicine and has several clinical applications. PGx role in practice is known, however, it hasn’t been widely adopted yet. In this study, we aim to investigate the perspectives Greek physicians regarding implementation testing key issues associated with via one-to-one interviews. Fourteen semi-structured interviews, mostly online, were conducted. Transcripts coded independently compared by two members research team. Descriptive statistics generated using Excel. Results: Six main themes emerged: awareness use testing; source information; stakeholders supply chain, their interactions change agents; benefit significance barriers lack reimbursement; recommendations boost adoption rate. Most respondents aware applications but only three them had already recommended a testing. Peer-reviewed journals along guidelines regarded as most used information while chain discussed. was considered that will promote patient-centered care, can enhance medication effectiveness, decrease risk side effects reduce healthcare costs. Lack reimbursement, scarcity resources, high cost foremost affecting adoption. Conclusions: It concluded if case reimbursed physicians’ training reinforced, be boosted improved shortly.

Язык: Английский

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