Vaccination and personalized cancer vaccines focusing on common cancers in women: a narrative review
Pathology - Research and Practice,
Год журнала:
2025,
Номер
270, С. 155983 - 155983
Опубликована: Апрель 18, 2025
Язык: Английский
Lipoplexes’ Structure, Preparation, and Role in Managing Different Diseases
AAPS PharmSciTech,
Год журнала:
2024,
Номер
25(5)
Опубликована: Июнь 7, 2024
Язык: Английский
Redefining Hepatocellular Carcinoma Treatment: Nanotechnology Meets Tumor Immune Microenvironment
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 47
Опубликована: Март 13, 2025
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
lethal
malignancies
worldwide,
characterized
by
its
complex
pathogenesis
and
poor
therapeutic
outcomes.
Despite
recent
advances
in
targeted
molecular
therapies,
immune
checkpoint
inhibitors
(ICIs),
radiotherapy,
conventional
chemotherapy,
five-year
survival
rate
for
this
neoplasm
remains
dismally
low.
The
progress
nanotechnology
has
revolutionized
cancer
treatment
years.
These
provide
unprecedented
opportunities
to
overcome
current
limitations
different
modalities.
This
review
provides
a
comprehensive
analysis
how
interfaces
with
tumor
microenvironment
(TIME)
HCC
can
present
new
frontier
interventions
HCC.
We
critically
overview
latest
developments
nanoparticle-based
delivery
systems
various
drugs
also
other
antitumor
agents
like
thermal
therapy
radiotherapy.
highlight
unique
ability
nanoparticles
modulate
immunosuppressive
(TME)
enhance
efficacy.
Furthermore,
we
analyze
emerging
strategies
that
exploit
nanoformulations
biological
barriers
drug
bioavailability
treatment.
Язык: Английский
Advancements and challenges in personalized neoantigen-based cancer vaccines
Oncology Reviews,
Год журнала:
2025,
Номер
19
Опубликована: Март 14, 2025
Advancements
in
personalized
neoantigen-based
cancer
vaccines
are
ushering
a
new
era
oncology,
targeting
unique
genetic
alterations
within
tumors
to
enhance
treatment
precision
and
efficacy.
Neoantigens,
specific
cells
absent
normal
tissues,
at
the
heart
of
these
vaccines,
promising
direct
immune
system
specifically
against
tumor,
thereby
maximizing
therapeutic
efficacy
while
minimizing
side
effects.
The
identification
neoantigens
through
genomic
proteomic
technologies
is
central
developing
allowing
for
precise
mapping
tumor's
mutational
landscape.
Despite
advancements,
accurately
predicting
which
will
elicit
strong
responses
remains
challenging
due
tumor
variability
complexity
interactions.
This
necessitates
further
refinement
bioinformatics
tools
predictive
models.
Moreover,
heavily
depends
on
innovative
delivery
methods
that
neoantigen
presentation
system.
Techniques
like
encapsulating
lipid
nanoparticles
using
viral
vectors
critical
improving
vaccine
stability
delivery.
Additionally,
contribute
towards
achieving
Sustainable
Development
Goal
3.8,
promoting
universal
health
coverage
by
advancing
access
safe
effective
treatments.
review
delves
into
potential
transform
treatment,
examining
both
revolutionary
advancements
ongoing
challenges
they
face.
Язык: Английский
Harnessing Histone Deacetylase Inhibitors for Enhanced Cancer Immunotherapy
European Journal of Pharmacology,
Год журнала:
2025,
Номер
997, С. 177620 - 177620
Опубликована: Апрель 14, 2025
Язык: Английский
Approaches and challenges in cancer immunotherapy pathways
World Journal of Clinical Oncology,
Год журнала:
2024,
Номер
15(3), С. 378 - 380
Опубликована: Март 22, 2024
Cancer
immunotherapy
is
an
effective
with
critical
approaches
in
the
treatment
of
oncological
patients.
Whilst
numerous
research
and
clinical
trials
are
underway
to
develop
endogenous
approaches,
it
necessary
focus
on
fundamental
issues
identify
barriers
basic
progress.
Addressing
these
challenges
new
pathways
will
require
researchers
clinicians
join
forces
accelerate
understanding
complex
interactions
between
cancer
immune
system
resources
developing
better
treatments
for
Язык: Английский
Intranasal LAG3 antibody infusion induces a rapid antidepressant effect via the hippocampal ERK1/2-BDNF signaling pathway in chronically stressed mice
Neuropharmacology,
Год журнала:
2024,
Номер
259, С. 110118 - 110118
Опубликована: Авг. 15, 2024
Язык: Английский
Immunoadjuvants in Cancer Immunotherapy
Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 311 - 350
Опубликована: Авг. 28, 2024
Immunoadjuvants
are
crucial
components
of
cancer
immunotherapy
that
enhance
immune
responses
against
tumors.
This
chapter
explores
the
underlying
mechanisms
and
clinical
uses
immunoadjuvants
in
immunotherapy.
Toll-like
receptor
agonists
STING
two
types
activate
cells
promote
anti-tumor
immunity.
Cytokine-based
have
potential
toxicity
off-target
effects,
but
nanotechnology
enables
precision
delivery
to
minimize
these
issues.
Personalized
approaches,
biomarker
discovery,
predictive
modeling
important
for
optimizing
treatment
responses.
Overall,
essential
tools
generating
strong
long-lasting
In
conclusion,
critical
immunotherapy,
playing
a
vital
role
boosting
durable
Язык: Английский