A RETROSPECTIVE INVESTIGATION OF BLOOD COAGULATIVE PARAMETERS PT, KPTT, PROTEIN C, AND ANTITHROMBON III IN 95 PATIENTS WITH LIVER DISEASE DOI Open Access

George Zhu,

Broekmans Aw,

RM Bertina

и другие.

Universal Journal of Pharmaceutical Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Background: The liver is a crucial synthesis of blood coagulation factors and anticoagulative serine proteases such as protein C(PC) antithrombin III (ATIII), which exerts key role in the regulation hemostatic balance. Activated C(APC) S complex inactivate activated factor Va VIIIa, thus limiting Xa thrombin formation. excess can drive cancer cellular proliferation cell survival through oncogenic receptor Axl. In presence heparin binding, (ATIII) form an inactive 1:1 molar ratio. ATIII also IXa, Xa, XIa XIIa at slow rate. setting diseases, this reduced dysregulation be attributed to decreased by increased consumption coagulative C ATIII. Methods: current study, using routine detection for parameters 75 patients with diseases. Results: results showed that there exist one or three PT, KPTT, TT abnormal longer. Moreover, intensity was associated severity our 20 cirrhosis, significantly plasma antigen (PC:Ag 0.5501 vs 1.0578 µ/ml) level (ATIII: Ag 21.8 39.8 mg/dl, ATIII:C 40.25 105.04%), respectively. Conclusions: measurement multidispillary analyses system are helpful monitoring diseases might play predictable marker. Peer Review History: Received 13 September 2024; Reviewed November; Accepted 26 December; Available online 15 January 2025 Academic Editor: Dr. Marwa A. Fayed, University Sadat City, Egypt, [email protected] Average review marks initial stage: 6.0/10 publication 7.0/10

Язык: Английский

A RETROSPECTIVE INVESTIGATION OF BLOOD COAGULATIVE PARAMETERS PT, KPTT, PROTEIN C, AND ANTITHROMBON III IN 95 PATIENTS WITH LIVER DISEASE DOI Open Access

George Zhu,

Broekmans Aw,

RM Bertina

и другие.

Universal Journal of Pharmaceutical Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Background: The liver is a crucial synthesis of blood coagulation factors and anticoagulative serine proteases such as protein C(PC) antithrombin III (ATIII), which exerts key role in the regulation hemostatic balance. Activated C(APC) S complex inactivate activated factor Va VIIIa, thus limiting Xa thrombin formation. excess can drive cancer cellular proliferation cell survival through oncogenic receptor Axl. In presence heparin binding, (ATIII) form an inactive 1:1 molar ratio. ATIII also IXa, Xa, XIa XIIa at slow rate. setting diseases, this reduced dysregulation be attributed to decreased by increased consumption coagulative C ATIII. Methods: current study, using routine detection for parameters 75 patients with diseases. Results: results showed that there exist one or three PT, KPTT, TT abnormal longer. Moreover, intensity was associated severity our 20 cirrhosis, significantly plasma antigen (PC:Ag 0.5501 vs 1.0578 µ/ml) level (ATIII: Ag 21.8 39.8 mg/dl, ATIII:C 40.25 105.04%), respectively. Conclusions: measurement multidispillary analyses system are helpful monitoring diseases might play predictable marker. Peer Review History: Received 13 September 2024; Reviewed November; Accepted 26 December; Available online 15 January 2025 Academic Editor: Dr. Marwa A. Fayed, University Sadat City, Egypt, [email protected] Average review marks initial stage: 6.0/10 publication 7.0/10

Язык: Английский

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