Response to Comment on Baranova et al. Causal Associations Between Basal Metabolic Rate and COVID-19. Diabetes 2023;72:149–154 DOI Open Access
Fuquan Zhang, Ancha Baranova

Diabetes, Год журнала: 2023, Номер 72(8), С. e8 - e8

Опубликована: Июль 20, 2023

Kloecker, Brage, and Wareham (1) have provided an important argument in the discussion of major metabolic correlates incidence severity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Indeed, as individuals with obesity a higher basal rate (BMR) than lean control (2), increase susceptibility to disease 2019 (COVID-19) at BMR is not surprising.As prediction equations rely on BMI body composition measurements, there risk that conclusions our study will be called trivial merely repeat previous findings describe contributor phenotypes COVID-19.To mitigate this risk, we taken Mendelian randomization (MR) analysis one step further by running secondary utilizing multivariable MR (MVMR) framework (3), which allows us estimate causal effect exposure outcome presence unobserved confounding factors, i.e., (4).In MVMR, accounting for type diabetes diminished significance observed association COVID-19, indicating overweight obesity, indeed, explain finding.Nevertheless, increased SARS-CoV-2 infection continued noticeable (odds ratio 1.09, CI 1.03-1.15,P = 4.82EÀ03) after similar adjustments were made, predictors selected UK Biobank can capture more or diabetes-related components.Most likely, genetic variation contributes but neither nor reflects preexisting dysfunction steady-state level energy homeostasis, including "classical" types inflammation, example, ones caused bacterial infections mechanical tissue injury, rather systemic inflammation underlining obesity.Altogether, point out it seems, its relationship COVID-19 outcomes might less expected.

Язык: Английский

Response to Comment on Baranova et al. Causal Associations Between Basal Metabolic Rate and COVID-19. Diabetes 2023;72:149–154 DOI Open Access
Fuquan Zhang, Ancha Baranova

Diabetes, Год журнала: 2023, Номер 72(8), С. e8 - e8

Опубликована: Июль 20, 2023

Kloecker, Brage, and Wareham (1) have provided an important argument in the discussion of major metabolic correlates incidence severity severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).Indeed, as individuals with obesity a higher basal rate (BMR) than lean control (2), increase susceptibility to disease 2019 (COVID-19) at BMR is not surprising.As prediction equations rely on BMI body composition measurements, there risk that conclusions our study will be called trivial merely repeat previous findings describe contributor phenotypes COVID-19.To mitigate this risk, we taken Mendelian randomization (MR) analysis one step further by running secondary utilizing multivariable MR (MVMR) framework (3), which allows us estimate causal effect exposure outcome presence unobserved confounding factors, i.e., (4).In MVMR, accounting for type diabetes diminished significance observed association COVID-19, indicating overweight obesity, indeed, explain finding.Nevertheless, increased SARS-CoV-2 infection continued noticeable (odds ratio 1.09, CI 1.03-1.15,P = 4.82EÀ03) after similar adjustments were made, predictors selected UK Biobank can capture more or diabetes-related components.Most likely, genetic variation contributes but neither nor reflects preexisting dysfunction steady-state level energy homeostasis, including "classical" types inflammation, example, ones caused bacterial infections mechanical tissue injury, rather systemic inflammation underlining obesity.Altogether, point out it seems, its relationship COVID-19 outcomes might less expected.

Язык: Английский

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