Wearables in Chronomedicine and Interpretation of Circadian Health
Diagnostics,
Год журнала:
2025,
Номер
15(3), С. 327 - 327
Опубликована: Янв. 30, 2025
Wearable
devices
have
gained
increasing
attention
for
use
in
multifunctional
applications
related
to
health
monitoring,
particularly
research
of
the
circadian
rhythms
cognitive
functions
and
metabolic
processes.
In
this
comprehensive
review,
we
encompass
how
wearables
can
be
used
study
disease.
We
highlight
importance
these
as
markers
well-being
potential
predictors
outcomes.
focus
on
wearable
technologies
sleep
research,
medicine,
chronomedicine
beyond
domain
emphasize
actigraphy
a
validated
tool
monitoring
sleep,
activity,
light
exposure.
discuss
various
mathematical
methods
currently
analyze
actigraphic
data,
such
parametric
non-parametric
approaches,
linear,
non-linear,
neural
network-based
applied
quantify
non-circadian
variability.
also
introduce
novel
actigraphy-derived
markers,
which
personalized
proxies
status,
assisting
discriminating
between
disease,
offering
insights
into
neurobehavioral
status.
lifestyle
factors
physical
activity
exposure
modulate
brain
health.
establishing
reference
standards
measures
further
refine
data
interpretation
improve
clinical
The
review
calls
existing
tools
methods,
deepen
our
understanding
health,
develop
healthcare
strategies.
Язык: Английский
Molecular insights of exercise therapy in disease prevention and treatment
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Май 29, 2024
Despite
substantial
evidence
emphasizing
the
pleiotropic
benefits
of
exercise
for
prevention
and
treatment
various
diseases,
underlying
biological
mechanisms
have
not
been
fully
elucidated.
Several
attributed
to
signaling
molecules
that
are
released
in
response
by
different
tissues
such
as
skeletal
muscle,
cardiac
adipose,
liver
tissue.
These
molecules,
which
collectively
termed
exerkines,
form
a
heterogenous
group
bioactive
substances,
mediating
inter-organ
crosstalk
well
structural
functional
tissue
adaption.
Numerous
scientific
endeavors
focused
on
identifying
characterizing
new
mediators
with
properties.
Additionally,
some
investigations
molecular
targets
exerkines
cellular
cascades
trigger
adaption
processes.
A
detailed
understanding
tissue-specific
downstream
effects
is
crucial
harness
health-related
mediated
improve
targeted
programs
health
disease.
Herein,
we
review
current
vivo
exerkine-induced
signal
transduction
across
multiple
target
highlight
preventive
therapeutic
value
exerkine
diseases.
By
aspects
research,
provide
comprehensive
overview
(i)
underpinnings
secretion,
(ii)
receptor-dependent
receptor-independent
adaption,
(iii)
clinical
implications
these
disease
treatment.
Язык: Английский
Molecular aspects of the exercise response and training adaptation in skeletal muscle
Free Radical Biology and Medicine,
Год журнала:
2024,
Номер
223, С. 53 - 68
Опубликована: Июль 24, 2024
Skeletal
muscle
plasticity
enables
an
enormous
potential
to
adapt
various
internal
and
external
stimuli
perturbations.
Most
notably,
changes
in
contractile
activity
evoke
a
massive
remodeling
of
biochemical,
metabolic
force-generating
properties.
In
recent
years,
large
number
signals,
sensors,
regulators
effectors
have
been
implicated
these
adaptive
processes.
Nevertheless,
our
understanding
the
molecular
underpinnings
training
adaptation
remains
rudimentary.
Specifically,
mechanisms
that
underlie
signal
integration,
output
coordination,
functional
redundancy
other
complex
traits
are
unknown.
fact,
it
is
even
unclear
how
stimulus-dependent
specification
brought
about
endurance
or
resistance
exercise.
this
review,
we
will
provide
overview
on
events
describe
acute
perturbations
single
exercise
bouts.
Furthermore,
insights
into
principles
long-term
adaptation.
Finally,
current
gaps
knowledge
be
identified,
strategies
for
multi-omic
–cellular
analyses
skeletal
engaged
individual,
bouts
chronic
discussed.
Язык: Английский
The Impact of Physical Exercise on Male Fertility Through Its Association with Various Processes and Aspects of Human Biology
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(10), С. 3442 - 3442
Опубликована: Май 14, 2025
Background/Objective:
Infertility
affects
approximately
10–15%
couples
in
industrialized
countries.
It
has
numerous
causes,
including
genetic
and
environmental
factors,
lifestyle
choices,
physiological
disorders.
The
increasing
prevalence
of
infertility
underlines
the
importance
research
into
interventions
to
improve
reproductive
health,
with
a
strong
focus
on
physical
activity.
was
traditionally
mainly
directed
toward
female
health.
Although
male
factor
is
being
increasingly
accepted
as
equally
important,
this
area
remains
under-researched.
current
review
focuses
impact
activity
fertility
through
its
effects
immune
function,
cardiovascular
system,
hormonal
balance,
metabolism,
interaction
system.
Materials
Methods:
A
comprehensive
literature
studies
addressing
conducted
using
PubMed/Medline,
Scopus,
Web
Science.
Mostly
recent
were
included,
small
number
older
ones
included
cases
when
their
content
relevant.
focused
articles
studying
processes
involved
associations
between
effects,
endocrine
modulation,
influence
obesity
insulin
body.
Results:
findings
revealed
existence
fairly
consensus
that
moderate
enhances
semen
quality,
metabolic
positively
influencing
fertility.
Physical
reduces
inflammation
oxidative
stress,
functioning,
contributes
oxygen
nutrient
supply
organs.
On
contrary,
strenuous
training
can
adversely
affect
fertility,
mostly
disruption
stress.
also
have
various
indirect
sports-related
behavior
incidents,
such
wearing
tight-fitting
clothes
or
overheating.
Conclusions:
ways,
health
performed
at
intensity.
Understanding
balance
beneficial
excessive
exercise
well
incidental
factors
related
performing
sports
regularly
are,
thus,
extremely
important
optimizing
lifestyle-oriented
aimed
improvement.
Язык: Английский