International Journal of Molecular Medicine,
Год журнала:
2024,
Номер
55(2)
Опубликована: Дек. 18, 2024
Mental
stress
may
lead
to
ovarian
dysfunction.
Psychological
disrupts
function,
leading
adverse
in
vitro
fertilization
outcomes,
premature
insufficiency
and
decreased
reserve.
Furthermore,
psychological
caused
by
function
infertility
can
exacerbate
the
mental
burden.
In
animals,
leads
insufficiency,
resulting
in
irregular
estrous
cycles
The
present
study
summarizes
effects
of
psychogenic
on
underlying
mechanisms,
highlighting
involvement
hypothalamic‑pituitary‑adrenal,
sympathetic‑adrenal‑medullary
hypothalamic‑pituitary‑ovarian
axes,
as
well
neuroendocrine‑metabolic
network.
Moreover,
review
outlines
intervention
metabolic
strategies
for
improving
offering
potential
new
approaches
treating
hypofunction.
aims
clarify
understanding
stress‑induced
dysfunction
propose
alternative
infertility.
JAMA Network Open,
Год журнала:
2022,
Номер
5(11), С. e2240788 - e2240788
Опубликована: Ноя. 8, 2022
Unhealthy
sleep
behaviors
and
disturbances
are
associated
with
higher
risk
of
multiple
diseases
mortality.
The
current
profiles
habits
disturbances,
particularly
the
differences
between
workdays
free
days,
unknown
in
contemporary
US.To
comprehensively
evaluate
on
days
prevalence
among
US
adults.This
study
is
a
cross-sectional
analysis
nationally
representative
data
from
National
Health
Nutrition
Examination
Survey
(2017-2020)
adults
aged
20
years
or
older.
Data
was
performed
February
to
May
2022.The
main
outcomes
were
means
and/or
distributions
habits,
including
duration
sleep-wake
timing
debt
(ie,
difference
mean
weekly
duration),
social
jet
lag
midpoint
wake
time
days).
Prevalence
trouble
sleeping
participants
told
doctor
other
health
professional
that
they
have
sleeping)
daytime
sleepiness
self-reported
feeling
being
overly
sleepy
during
day
≥5
times
per
month)
also
determined.A
total
9004
individuals
(mean
[SE]
age,
48.3
[0.53]
years;
4635
women
[51.9%];
3158
non-Hispanic
White
[62.8%])
included
study.
7.59
hours
(95%
CI,
7.54
7.64
hours)
8.24
8.17
8.31
(difference,
0.65
hour).
at
11:02
pm
10:57
11:17
pm)
6:41
am
6:36
6:45
am),
respectively,
11:25
11:21
11:35
7:41
7:37
7:46
(differences,
0.23
hour
for
1.00
time).
On
workdays,
23.1%
21.3%
24.9%)
slept
less
than
7
25.4%
24.1%
26.6%)
went
midnight
later;
corresponding
percentages
changed
12.9%
11.6%
14.1%)
40.9%
38.4%
43.5%),
days.
Furthermore,
0.73
0.68
0.77
hours),
1.10
1.05
1.15
hours);
30.5%
26.8%
33.3%)
experienced
1
more
debt,
46.5%
42.6%
50.3%)
lag.
29.8%
28.2%
31.5%),
27.2%
25.0%
29.5%).In
2017
2020,
showed
variability
longer
later
phases
high
long-term
deprivation,
chronic
lag,
frequent
disturbances.
These
findings
provide
evidence
further
investigate
potential
approaches
optimize
overall
health.
JAMA Network Open,
Год журнала:
2024,
Номер
7(3), С. e241147 - e241147
Опубликована: Март 5, 2024
Importance
Understanding
the
interplay
between
sleep
duration,
dietary
habits,
and
risk
of
developing
type
2
diabetes
(T2D)
is
crucial
for
public
health
prevention
strategies.
Objective
To
investigate
associations
diet
duration
with
development
T2D.
Design,
Setting,
Participants
Data
derived
from
UK
Biobank
baseline
investigation
(2006-2010)
were
analyzed
this
cohort
study
May
1
September
30,
2023.
The
association
healthy
patterns
T2D
was
investigated
during
a
median
(IQR)
follow-up
12.5
(11.8-13.2)
years
(end
follow-up,
2021).
Exposure
For
analysis,
247
867
participants
categorized
into
4
groups:
normal
(7-8
hours
per
day),
mild
short
(6
moderate
(5
extreme
(3-4
day).
Their
habits
evaluated
based
on
population-specific
consumption
red
meat,
processed
fruits,
vegetables,
fish,
resulting
in
score
ranging
0
(unhealthiest)
to
5
(healthiest).
Main
Outcomes
Measures
Cox
proportional
hazards
regression
analysis
used
calculate
hazard
ratios
(HRs)
95%
CIs
across
various
groups
scores.
Results
comprised
mean
[SD]
age
55.9
[8.1]
years,
whom
52.3%
female.
During
3.2%
diagnosed
hospital
registry
data.
adjusted
confounding
variables,
indicated
significant
increase
among
or
less
daily
sleep.
Individuals
sleeping
day
exhibited
1.16
HR
(95%
CI,
1.05-1.28),
individuals
3
1.41
1.19-1.68)
compared
duration.
Furthermore,
healthiest
had
reduced
(HR,
0.75
[95%
0.63-0.88]).
increased
persisted
even
following
diet,
but
there
no
multiplicative
interaction
score.
Conclusions
Relevance
In
involving
residents,
habitual
associated
This
who
maintained
diet.
validate
these
findings,
further
longitudinal
studies
are
needed,
incorporating
repeated
measures
(including
objective
assessments)
habits.
To
determine
trends
in
prevalence
of
short
sleep
duration
and
trouble
sleeping
among
US
adults
from
2005
to
2018,
assess
how
vary
by
sex
race/ethnicity.Seven
cycles
the
National
Health
Nutrition
Examination
Survey
data
between
2005-2006
2017-2018
were
analyzed.
Trouble
self
reported.
Short
was
defined
as
≤6
hr.
Age-standardized
reporting
a
health
care
provider
estimated
overall
adult
population,
race/ethnicity.From
2014,
age-adjusted
remained
similar
population
(p
for
trend
>0.05).
Non-Hispanic
Black
people
had
highest
all
race/ethnicity
groups
seven
cycles.
The
appears
lower
2015-2018
than
2005-2014
due
different
measurement
methods
applied.
However,
there
increasing
both
men
women,
<0.05).
Among
groups,
non-Hispanic
White
healthcare
provider.Findings
depict
persistence
sleep-related
issues
United
States
possible
risk
factors,
well
racial
disparities.
Insufficient
or
excessive
sleep
duration
are
associated
with
increased
risk
of
individual
adverse
outcomes.
However,
it
remains
largely
unknown
whether
trajectories
overall
health
among
older
adults.
This
study
aimed
to
examine
the
association
between
and
successful
aging.
Annals of the New York Academy of Sciences,
Год журнала:
2021,
Номер
1506(1), С. 18 - 34
Опубликована: Авг. 2, 2021
Abstract
The
human
circadian
system
consists
of
the
master
clock
in
suprachiasmatic
nuclei
hypothalamus
as
well
peripheral
molecular
clocks
located
organs
throughout
body.
This
plays
a
major
role
temporal
organization
biological
and
physiological
processes,
such
body
temperature,
blood
pressure,
hormone
secretion,
gene
expression,
immune
functions,
which
all
manifest
consistent
diurnal
patterns.
Many
facets
modern
life,
work
schedules,
travel,
social
activities,
can
lead
to
sleep/wake
eating
schedules
that
are
misaligned
relative
clock.
misalignment
disrupt
impair
psychological
parameters
may
ultimately
put
people
at
higher
risk
for
chronic
diseases
like
cancer,
cardiovascular
disease,
other
metabolic
disorders.
Understanding
mechanisms
regulate
sleep
rhythms
insights
on
behavioral
interventions
lower
these
diseases.
On
February
25,
2021,
experts
sleep,
rhythms,
chronobiology
met
virtually
Keystone
eSymposium
“Sleep
&
Circadian
Rhythms:
Pillars
Health”
discuss
latest
research
understanding
bidirectional
relationships
between
health
disease.
Abstract
Background
China
is
among
the
largest
and
fastest
aging
countries.
The
elderly
population
more
vulnerable,
with
higher
proportion
of
inappropriate
sleep
duration
risk
mortality,
compared
young
middle-aged
adults.
Single-measured
has
been
associated
but
health
effects
long-term
trajectories
remain
unknown.
This
study
aimed
to
explore
prospective
associations
between
all-cause
mortality
Chinese
elderly.
Methods
Participants
(
n
=
3,895;
median
age:
82
years;
females:
53.3%)
who
reported
in
all
three
surveys
(2005,
2008,
2011)
from
community-based
Longitudinal
Healthy
Longevity
Survey
(CLHLS)
were
followed
up
until
2019
(about
8
years).
We
identified
by
latent
class
mixed
model
explored
their
association
using
Cox
hazard
proportional
regression
Laplace
models.
Further,
stratified
analysis
demographic
characteristics
lifestyles
sensitivity
lag
effect,
health-related
factors,
inverse
probability
weighting
used
verify
robustness
association.
In
addition,
we
threshold
effect
baseline
on
mortality.
Results
documented
1,881
deaths
during
16,689
person-years
follow-up.
Five
identified:
moderately
increased
trajectory
(28.1%),
rapidly
(7.2%),
persistent
7
h
(33.7%),
decreased
(21.3%),
(9.7%).
Compared
h,
multivariable-adjusted
HRs
(95%
CI
)
for
trajectory,
1.21
(1.08,
1.36),
(1.01,
1.44),
0.95
(0.82,
1.10),
0.93
(0.78,
1.11),
respectively;
corresponding
difference
survival
time
-0.53
(-1.01,
-0.05),
-0.43
(0.16,
-1.02),
0.26
(-0.34,
0.86),
0.25
(-0.51,
1.02),
respectively.
Stratified
analyses
showed
consistent
results.
Threshold
indicated
a
sharply
participants
whose
exceeds
9
HR
1.20,
95%
:
1.11,
1.30).
Conclusion
subsequent
Those
report
exceeding
may
be
at
high
Journal of Affective Disorders,
Год журнала:
2024,
Номер
362, С. 126 - 133
Опубликована: Июнь 28, 2024
The
association
of
a
single
time-point
measure
sleep
duration
with
cardio-metabolic
disease
has
been
extensively
studied,
but
few
studies
have
focused
on
the
impact
trajectory.
This
study
aims
to
model
trajectory
as
predictors
for
subsequent
development
disease.