bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Май 18, 2024
A
growing
body
of
data
suggests
that
skeletal
muscle
contractile
function
and
glucose
metabolism
vary
by
time-of-day,
with
chronobiological
effects
on
intrinsic
properties
being
proposed
as
the
underlying
mediator.
However,
no
studies
have
directly
investigated
or
in
over
a
24
h
circadian
cycle.
To
address
this,
we
assessed
endurance,
well
contraction-stimulated
uptake,
isolated
extensor
digitorum
longus
soleus
from
female
mice
at
four
times-of-day
(Zeitgeber
Times
1,
7,
13,
19).
Significantly,
while
both
muscles
demonstrated
circadian-related
changes
gene
expression,
function,
uptake
were
not
different
between
time
points.
Overall,
these
results
demonstrate
time-of-day
variation
exercise
performance
glycemia-reducing
benefits
are
due
to
uptake.
Sleep Medicine Reviews,
Год журнала:
2024,
Номер
75, С. 101926 - 101926
Опубликована: Март 21, 2024
The
number
of
individuals
experiencing
sleep
loss
has
exponentially
risen
over
the
past
decades.
Extrapolation
laboratory
findings
to
real
world
suggests
that
females
are
more
affected
by
extended
wakefulness
and
circadian
misalignment
than
males
are.
Therefore,
long-term
effects
such
as
metabolism
disorders
likely
be
prevalent
in
males.
Despite
emerging
evidence
for
sex
differences
key
aspects
sleep-wake
regulation,
much
remains
unknown,
often
underrepresented
research.
This
brief
communication
is
intended
highlight
1)
how
systematically
impinge
on
regulation
humans,
2)
factors
modulate
metabolism,
3)
meaning
these
precision
medicine.
Ultimately,
justify
factoring
when
optimizing
individually
targeted
interventions
humans.
Diabetes Care,
Год журнала:
2024,
Номер
47(5), С. 890 - 897
Опубликована: Апрель 9, 2024
To
assess
the
association
between
timing
of
aerobic
moderate
to
vigorous
physical
activity
(MVPA)
and
risk
cardiovascular
disease
(CVD),
microvascular
(MVD),
all-cause
mortality
in
adults
with
obesity
a
subset
type
2
diabetes
(T2D).
Medicine & Science in Sports & Exercise,
Год журнала:
2024,
Номер
56(10), С. 2076 - 2091
Опубликована: Сен. 15, 2024
ABSTRACT
Excessive
body
weight
and
adiposity
contribute
to
many
adverse
health
concerns.
The
American
College
of
Sports
Medicine
(ACSM)
recognizes
that
the
condition
excess
is
complex,
with
numerous
factors
warranting
consideration.
ACSM
published
a
position
stand
on
this
topic
in
2001
an
update
2009,
consensus
paper
role
physical
activity
prevention
gain
2019.
This
current
serves
as
additional
those
prior
papers.
supports
inclusion
medical
treatments
(pharmacotherapy,
metabolic
bariatric
surgery)
adiposity,
deemed
be
medically
appropriate,
provides
perspectives
within
these
therapies.
For
loss
gain,
effects
may
most
prevalent
when
progressed
appropriate
manner
at
least
150
min·wk
−1
moderate-intensity
activity,
benefits
occur
dose–response
manner.
High-intensity
interval
training
does
not
appear
superior
moderate-to-vigorous
for
regulation,
light-intensity
also
alternative
approach
provided
it
sufficient
energy
expenditure.
Evidence
support
any
one
single
mode
other
modes
or
loss,
elicit
holistic
beyond
multimodal
should
recommended.
interaction
between
expenditure
intake
exercise
control
appetite
are
variable
individuals.
Physical
interventions
inclusive
tailored
sex,
self-identified
gender,
race,
ethnicity,
socioeconomic
status,
age,
developmental
level.
Intervention
approaches
can
include
different
forms,
channels,
methods
activity.
Obesity,
Год журнала:
2024,
Номер
32(8), С. 1465 - 1473
Опубликована: Июнь 10, 2024
Moderate-to-vigorous
physical
activity
(MVPA)
improves
glucose
levels;
however,
whether
its
timing
affects
daily
glycemic
control
remains
unclear.
This
study
aims
to
investigate
the
impact
of
lifestyle
MVPA
on
in
sedentary
adults
with
overweight/obesity
and
metabolic
impairments.
Nutrients,
Год журнала:
2023,
Номер
15(19), С. 4202 - 4202
Опубликована: Сен. 28, 2023
Type
2
diabetes
mellitus
(T2DM)
is
one
of
the
most
widespread
diseases
worldwide.
Lifestyle
interventions,
including
diet
and
physical
activity
(PA),
are
fundamental
non-pharmacological
components
T2DM
therapy.
Exercise
interventions
strongly
recommended
for
people
with
or
at
risk
developing
already
overt
diabetes,
but
adherence
to
PA
guidelines
in
this
population
still
challenging.
Furthermore,
heterogeneity
patients,
driven
by
differing
residual
β-cell
functionality,
as
well
possibility
practicing
different
types
intensities
PA,
has
led
need
develop
tailored
exercise
training
plans.
Investigations
on
blood
glucose
variation
response
could
help
clarify
why
individuals
do
not
respond
same
way
guide
prescription
personalized
treatments.
The
aim
review
offer
an
updated
overview
current
evidence
effects
regimens
modalities
regarding
sensing
secretory
dynamics
prediabetes
T2DM,
a
special
focus
function.
Abstract
Background
Physical
activity
reduces
colorectal
cancer
risk,
yet
the
diurnal
timing
of
physical
in
etiology
remains
unclear.
Methods
This
study
used
24-h
accelerometry
time
series
from
UK
Biobank
participants
aged
42
to
79
years
derive
circadian
patterns
using
functional
principal
component
analysis.
Multivariable
Cox
proportional
hazard
models
were
examine
associations
with
risk.
Results
Among
86,252
(56%
women),
529
cases
occurred
during
a
median
5.3-year
follow-up.
We
identified
four
that
explained
almost
100%
data
variability
day.
A
pattern
continuous
day-long
was
inversely
associated
risk
(hazard
ratio
(HR)
=
0.94,
95%
confidence
interval
(CI)
0.89–0.99).
second
late-day
suggestively
related
(HR
0.93,
CI
0.85–1.02).
third
early-
plus
decreased
0.89,
0.80–0.99).
fourth
mid-day
night-time
showed
no
relation
1.02,
0.88–1.19).
Our
results
consistent
across
various
sensitivity
analyses,
including
restriction
never
smokers,
exclusion
first
2
follow-up,
and
adjustment
for
shift
work.
Conclusions
is
reduced
beyond
benefits
overall
activity.
Further
research
needed
confirm
role
prevention.
The Journal of Physiology,
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 5, 2023
Twenty-four
hour
rhythmicity
in
whole-body
substrate
metabolism,
skeletal
muscle
clock
gene
expression
and
mitochondrial
respiration
is
compromised
upon
insulin
resistance.
With
exercise
training
known
to
ameliorate
resistance,
our
objective
was
test
if
can
reinforce
diurnal
variation
metabolism
men
with
In
a
single-arm
longitudinal
design,
10
overweight
obese
resistance
performed
12
weeks
of
high-intensity
interval
recurrently
the
afternoon
(between
14.00
18.00
h)
were
tested
pre-
post-exercise
training,
while
staying
metabolic
research
unit
for
2
days
under
free-living
conditions
regular
meals.
On
second
days,
indirect
calorimetry
at
08.00,
13.00,
18.00,
23.00
04.00
h,
biopsies
taken
from
vastus
lateralis
08.30,
13.30
23.30
blood
drawn
least
bi-hourly
over
24
h.
Participants
did
not
lose
body
weight
weeks,
but
improved
composition
capacity.
Exercise
resulted
reduced
24-h
plasma
glucose
levels,
modify
free
fatty
acid
triacylglycerol
levels.
Diurnal
modified
by
period
genes
showing
an
interaction
(time
×
exercise)
effect
mRNA
levels
13.00
increased
without
inducing
variation.
Twenty-four-hour
energy
expenditure
remained
unchanged.
Future
studies
should
investigate
alternative
strategies
or
types
interventions
(e.g.
diet
drugs
aiming
improving
sensitivity)
their
capacity
respiration.
KEY
POINTS:
Insulin
associated
blunted
flexibility
respiration,
disruptions
molecular
circadian
clock.
We
hypothesized
that
modifies
found
inflexibility
h
persisted
after
whereas
independent
time
day.
Gene
Per1-3
Rorα
changed
particularly
close
day
which
performed.
These
results
provide
rationale
further
differential
impact
differently
timed
treat
defects
manifest
particular
The Journal of Physiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Март 24, 2024
Abstract
Exercise
is
recommended
in
the
treatment
of
type
2
diabetes
and
can
improve
insulin
sensitivity.
However,
previous
evidence
suggests
that
exercise
at
different
times
day
people
with
may
have
opposing
outcomes
on
glycaemia.
Metformin
most
commonly
prescribed
initial
pharmacological
intervention
diabetes,
alter
adaptions
to
exercise.
It
unknown
if
there
an
interaction
between
metformin
diurnal
outcomes.
We
aimed
investigate
glycaemic
moderate
intensity
morning
vs
.
evening
being
monotherapy.
In
this
study,
nine
males
females
undergoing
monotherapy
(age
61
±
8.2
years,
mean
SD)
completed
a
16‐week
crossover
trial
including
2‐week
baseline
recording,
6
weeks
randomly
assigned
(07.00–10.00
h)
or
(16.00–19.00
wash‐out
period.
arms
consisted
30
min
walking
70%
estimated
max
heart
rate
every
other
day.
Glucose
levels
were
measured
continuous
glucose
monitors
activity
by
wrist‐worn
monitors.
Food‐intake
was
recorded
4‐day
food
diaries
during
baseline,
first
last
each
arm.
There
no
difference
intensity,
total
caloric
intake
physical
arms.
As
primary
outcomes,
acute
(24
area
under
curve
(AUC),
lower
(
P
=
0.02)
after
(180.6
68.4
mmol/l)
compared
(210.3
76.7
mmol/l);
differences
identified
for
(mmol/l)
any
specific
time
point
when
data
analysed
two‐way
ANOVA.
secondary
AUC
significantly
0.01)
participants
taking
before
breakfast
(152.5
29.95
(227.2
61.51
only
arm;
5–6
protocol,
0.04)
(168.8
15.8
mmol/l),
rather
than
(224.5
52.0
Our
reveal
acutely
lowers
metformin.
This
appears
be
driven
individuals
consumed
prior
breakfast.
beneficial
effect
upon
combined
pre‐breakfast
persisted
through
final
trial.
findings
suggest
benefit
management
glycaemia
diabetes.
image
Key
points
Morning
persistently
reduced
post‐breakfast
week
(week
6)
intervention.
study
it
possible
make
simple
changes
take
perform
their
blood
glucose.