Did We Overreact? Insights on COVID-19 Disease and Vaccination in a Large Cohort of Immune-Mediated Inflammatory Disease Patients during Sequential Phases of the Pandemic (The BELCOMID Study)
Vaccines,
Год журнала:
2024,
Номер
12(10), С. 1157 - 1157
Опубликована: Окт. 11, 2024
Introduction:
As
the
COVID-19
pandemic
becomes
an
endemic
state,
still
many
questions
remain
regarding
risks
and
impact
of
SARS-CoV-2
infection
vaccination
in
patients
with
immune-mediated
inflammatory
diseases
(IMIDs)
who
were
excluded
from
phase
3
trials.
Methods:
The
BELCOMID
study
collected
patient
data
serological
samples
a
large,
multicentric
IMID
cohort
that
was
prospectively
followed
during
sequential
stages
pandemic.
Patients
stratified
according
to
status
into
five
groups
across
three
sampling
periods.
Interactions
between
infection,
status,
IMID-treatment
modalities
course
explored.
Results:
In
total,
2165
IBD,
dermatological
or
rheumatological
participated.
rates
increased
over
highest
had
refused
every
vaccine.
After
baseline
vaccination,
serologic
spike
(S)-antibody
responses
attenuated
by
particular
types
immune-modulating
treatment:
anti-TNF,
rituximab,
JAKi,
systemic
steroids,
combined
biologic/immunomodulator
treatment.
Nonetheless,
S-antibody
concentration
progressively
received
booster
reaching
100%
seroconversion
rate
two
vaccines.
Previous
found
as
predictor
higher
response.
vaccine
showed
lowest
S-seroconversion
(53.8%).
Multiple
logistic
regression
did
not
identify
previous
risk
factor
for
flare-up.
Furthermore,
no
flare-up
vaccination.
Conclusions:
Altogether,
provides
evidence
efficacy
safety
confirms
importance
repeated
patients.
Язык: Английский
Impact of Comorbidities and Skin Diseases on Post-Vaccination Reactions: A Study on COVID-19 Vaccinations in Poland
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(20), С. 6173 - 6173
Опубликована: Окт. 17, 2024
The
COVID-19
pandemic
necessitated
rapid
and
widespread
vaccination
efforts,
which
proved
critical
in
reducing
the
severity
mortality
of
virus.
However,
interplay
between
vaccinations,
pre-existing
skin
conditions,
other
comorbidities
still
needs
to
be
explored.
This
study
investigated
occurrence
adverse
events
following
immunization
(AEFIs)
with
vaccines
individuals
chronic
diseases
within
a
Central
European
cohort.
Язык: Английский