Transcranial direct current stimulation for upper and lower limb motor dysfunction after stroke: a systematic review and meta-analysis of randomized controlled trials DOI
Sun Ying, Fabrizio Vecchio,

Mou‐Xiong Zheng

и другие.

Brain Network and Modulation, Год журнала: 2025, Номер 4(1), С. 1 - 12

Опубликована: Янв. 1, 2025

Transcranial direct current stimulation (tDCS) has emerged as a promising noninvasive intervention for motor recovery after stroke, yet its therapeutic efficacy remains unclear. This study was designed to systematically evaluate the effectiveness of tDCS upper and lower extremity function in stroke patients. A comprehensive search conducted randomized controlled trials published before February 6, 2025, across five databases: PubMed, Embase, Web Science, Cochrane Library, Scopus. The Fugl-Meyer Assessment Scales Upper Lower Extremities served primary evaluation metrics, complemented by secondary measures, including Action Research Arm Test, Timed Up Go Barthel Index. Two independent investigators screened literature, Risk Bias Tool employed assess quality extract relevant data. total 24 were included analysis. Meta-analysis outcomes revealed that had positive effect on improving limb (mean difference ( MD ) = 1.628, 95% confidence interval CI ): 1.145-2.111, P < 0.001) but not improvement 1.133, : –0.031–2.298, 0.056). Subgroup analyses optimal parameters: anodal M1 region 1.707, 1.159–2.256), intensity ≥ 0.05 mA/cm 2 1.652, 0.862–2.442), treatment duration exceeding weeks 1.848, 0.703–2.994). Notably, benefits particularly evident during acute subacute rehabilitation phases. Current evidence suggests demonstrates clinically meaningful enhancement patients, whereas functional inconclusive.

Язык: Английский

Vagus nerve stimulation: A targeted approach for reducing tissue-specific ischemic reperfusion injury DOI

Parmeshar Singh,

Manju Chaudhary,

Jacob S Kazmi

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 184, С. 117898 - 117898

Опубликована: Фев. 8, 2025

Язык: Английский

Процитировано

1
Transcranial direct current stimulation for upper and lower limb motor dysfunction after stroke: a systematic review and meta-analysis of randomized controlled trials DOI
Sun Ying, Fabrizio Vecchio,

Mou‐Xiong Zheng

и другие.

Brain Network and Modulation, Год журнала: 2025, Номер 4(1), С. 1 - 12

Опубликована: Янв. 1, 2025

Transcranial direct current stimulation (tDCS) has emerged as a promising noninvasive intervention for motor recovery after stroke, yet its therapeutic efficacy remains unclear. This study was designed to systematically evaluate the effectiveness of tDCS upper and lower extremity function in stroke patients. A comprehensive search conducted randomized controlled trials published before February 6, 2025, across five databases: PubMed, Embase, Web Science, Cochrane Library, Scopus. The Fugl-Meyer Assessment Scales Upper Lower Extremities served primary evaluation metrics, complemented by secondary measures, including Action Research Arm Test, Timed Up Go Barthel Index. Two independent investigators screened literature, Risk Bias Tool employed assess quality extract relevant data. total 24 were included analysis. Meta-analysis outcomes revealed that had positive effect on improving limb (mean difference ( MD ) = 1.628, 95% confidence interval CI ): 1.145-2.111, P < 0.001) but not improvement 1.133, : –0.031–2.298, 0.056). Subgroup analyses optimal parameters: anodal M1 region 1.707, 1.159–2.256), intensity ≥ 0.05 mA/cm 2 1.652, 0.862–2.442), treatment duration exceeding weeks 1.848, 0.703–2.994). Notably, benefits particularly evident during acute subacute rehabilitation phases. Current evidence suggests demonstrates clinically meaningful enhancement patients, whereas functional inconclusive.

Язык: Английский

Процитировано

0