Prenatal, childhood and adolescent exposure to Volatile Organic Compounds and Health Outcomes: A Scoping Review protocol to Map the Level of Evidence (Preprint)
Опубликована: Янв. 29, 2025
BACKGROUND
VOCs
are
a
diverse
group
of
organic
chemicals
with
widespread
presence
in
daily
life.
may
have
detrimental
health
effects
on
humans,
particularly
during
critical
periods
such
as
pregnancy,
childhood,
and
adolescence.
OBJECTIVE
This
ongoing
scoping
review
aims
to
map
the
current
evidence
concerning
exposure
volatile
compounds
(VOCs)
associations
pregnancy
outcomes
METHODS
will
consider
studies
investigating
potential
related
exposures
either
total
or
any
following
six
specific
VOCs:
Benzene,
Toluene,
Ethylbenzene,
Xylene,
Trichloroethylene
(TCE),
Tetrachloroethylene/perchloroethylene
(PCE)
windows
from
through
Original
articles
published
English
January
1,
2000,
end
period,
be
included.
follow
JBI
methodology
for
reviews,
Preferred
Reporting
Items
Systematic
Reviews
Meta-Analyses
extension
Scoping
(PRISMA-ScR).
The
literature
search
use
Ovid
Medline,
Embase,
Web
Science
databases.
Two
reviewers
screen
extract
information
separately;
case
discrepancy,
both
discuss
reach
consensus,
third
reviewer
intervene
if
needed.
Reviewers
provide
commentaries
their
findings
included
suggest
areas
interest
future
studies.
RESULTS
yielded
7332
citations
screening
underway.
After
data
extraction
complementary
search,
results
submitted
publication
peer-reviewed
journal.
CONCLUSIONS
expected
summarize
state
knowledge
association
at
life
stages
(pregnancy,
adolescence).
We
anticipate
identifying
gaps
well
that
could
guide
research
priorities.
CLINICALTRIAL
Protocol
registration
(Open
Framework):
https://osf.io/ep73g
Язык: Английский