Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 DOI Creative Commons
Atharv Athavale, A Gaur,

Nafees Ahmed

и другие.

Vaccines, Год журнала: 2024, Номер 12(12), С. 1396 - 1396

Опубликована: Дек. 12, 2024

Background: The COVID-19 pandemic prompted unprecedented vaccine development efforts against SARS-CoV-2. India, which was one of the countries most impacted by COVID-19, developed its indigenous in addition to utilizing ones other countries. While antibody levels and neutralizing titres are considered initial correlates immune protection, long-term protection from pathogen relies on memory B T cells their recall responses. In this regard, global research has primarily focused mRNA-based vaccines. studies response, particularly cell response induced vaccines given Indians, remain relatively obscure. Methods: We assessed Receptor Binding Domain-specific peripheral circulation ability secrete antigen-specific antibodies among Indians vaccinated with Covaxin (BBV152), Covishield (AZD1222), Corbevax (BECOV2D), Sputnik Light, as well unvaccinated individuals. Results: Light conferred better antibody-secreting (ASC) responses over time compared groups. Conclusions: These findings contribute our understanding vaccine-induced Indian population; providing insights that could inform future strategies.

Язык: Английский

To be remembered: B cell memory response against SARS‐CoV‐2 and its variants in vaccinated and unvaccinated individuals DOI Open Access

Nafees Ahmed,

Atharv Athavale, Ankita Tripathi

и другие.

Scandinavian Journal of Immunology, Год журнала: 2023, Номер 99(2)

Опубликована: Дек. 6, 2023

Abstract COVID‐19 disease has plagued the world economy and affected overall well‐being life of most people. Natural infection as well vaccination leads to development an immune response against pathogen. This involves production antibodies, which can neutralize virus during future challenges. In addition, cellular memory with B T cells provides long‐lasting protection. The longevity been a subject intensive research in this field. extent immunity conferred by different forms or natural infections remained debatable for long. Hence, understanding effectiveness these responses among groups people assist government organizations making informed policy decisions. article, based on publicly available data, we have reviewed generated some vaccines SARS‐CoV‐2 its variants, particularly cell individuals.

Язык: Английский

Процитировано

5
Targeting Spike Protein: Modified Antibody for Broad-Spectrum Binding to Coronaviruses: An In Silico Study DOI Open Access

Rai RC

Virology & Immunology Journal, Год журнала: 2023, Номер 7(3), С. 1 - 15

Опубликована: Июль 7, 2023

An antibody-mediated immune response against the Spike protein is one of potential ways to target SARS-CoV-2 virus. The discovery a highly effective vaccine or an antiviral drug that specifically targets viral entry its replication pathway, are commonly pursued as way combat COVID-19-like situation. virus has RNA genetic material, which known for high mutation rate. This makes efficiency and efficacy it suboptimal later due continuous mutations in epitope region was evident case spread Omicron (B.1.1.529) variant. Here we tested in-silico approach towards finding antibody recognise bind across most variants. We achieved this by altering sequences VDJ heavy light chains natural human (Wuhan, PDB ID: 7BWJ). first antibodies be studied published along with crystal structure during mid2020, have ability neutralize Wuhan isolate. Iterative substitutions were induced 7BWJ sequence different combinations. After 28 iterations, found variants comparatively higher docking score. also showed many members Coronaviruses.

Язык: Английский

Процитировано

4
RBD specific B-cell Memory Responses among Vaccinated Individuals against SARS-CoV-2 DOI Open Access
Atharv Athavale, A Gaur,

Nafees Ahmed

и другие.

Опубликована: Авг. 6, 2024

During the last few years, world witnessed one of worst calamities to humankind- COVID-19 pandemic. We also development vaccines at an unprecedented pace against SARS-CoV-2- causative agent. India was among hard-hit countries by COVID-19, developed its indigenous vaccine and implemented in other as well. Initially, antibody level neutralizing titer pathogen were considered correlates immune protection from disease. However, long-term provided memory cells viz. T B their ability efficiently make recall responses. In this regard, globally research studies focused mainly on mRNA-based vaccines. The response, particularly- cell response bestowed given Indians is relatively obscure. studied RBD specific peripheral circulation study participants secrete antigen-specific antibodies vaccinated with Covaxin (BBV152), Covishield (AZD1222), Corbevax (BECOV2D) Sputnik Light (Gam-COVID-Vac) well unvaccinated individuals. Our revealed that conferred better antibody-secreting (ASC)

Язык: Английский

Процитировано

1
Receptor Binding Domain-Specific B Cell Memory Responses Among Individuals Vaccinated Against SARS-CoV-2 DOI Creative Commons
Atharv Athavale, A Gaur,

Nafees Ahmed

и другие.

Vaccines, Год журнала: 2024, Номер 12(12), С. 1396 - 1396

Опубликована: Дек. 12, 2024

Background: The COVID-19 pandemic prompted unprecedented vaccine development efforts against SARS-CoV-2. India, which was one of the countries most impacted by COVID-19, developed its indigenous in addition to utilizing ones other countries. While antibody levels and neutralizing titres are considered initial correlates immune protection, long-term protection from pathogen relies on memory B T cells their recall responses. In this regard, global research has primarily focused mRNA-based vaccines. studies response, particularly cell response induced vaccines given Indians, remain relatively obscure. Methods: We assessed Receptor Binding Domain-specific peripheral circulation ability secrete antigen-specific antibodies among Indians vaccinated with Covaxin (BBV152), Covishield (AZD1222), Corbevax (BECOV2D), Sputnik Light, as well unvaccinated individuals. Results: Light conferred better antibody-secreting (ASC) responses over time compared groups. Conclusions: These findings contribute our understanding vaccine-induced Indian population; providing insights that could inform future strategies.

Язык: Английский

Процитировано

0