Acta veterinaria, Год журнала: 2025, Номер 75(1), С. 25 - 37
Опубликована: Март 1, 2025
Abstract Listeriosis is an infectious and fatal disease affecting domestic mammals, poultry, humans worldwide. The effectiveness of local tissue expression acute phase proteins in listeriosis mammals not yet clear. aim this study to evaluate the 26 brainstem samples according distribution severity inflammation due natural sheep. material consisted paraffin blocks, including 20 from listeriosis-infected cases 6 healthy controls. Sections obtained blocks were subjected histopathological immunohistochemical analyses. Histopathological examination revealed normal histological structures brainstems control group. In contrast, sections exhibited findings such as micro abscesses composed neutrophil granulocytes microglial cells, gliosis, meningitis, congestion, perivascular cuffs, neuronal degeneration, neuronophagia. Based on inflammation, categorized into three groups: 5 mild (Group I), 8 moderate II), 7 severe III). Immunohistochemical analysis demonstrated significantly increased levels C-reactive protein (CRP), Haptoglobin (Hp), Serum Amyloid A (SAA) groups compared group, with highest statistical scores observed Group II III (p<0.001). suggest that acute-phase may play crucial roles pathophysiological processes naturally infected could express locally. Particularly, these progression provide valuable insights infection process.
Язык: Английский