Advanced Research in the Pathophysiology of Venous Thromboembolism–Acute Pulmonary Embolism

Biomedicines, Год журнала: 2025, Номер 13(4), С. 906 - 906

Опубликована: Апрель 8, 2025

According to the literature, cardiovascular diseases (CVDs)—including myocardial infarction, stroke, and venous thromboembolism (VTE)—are among leading causes of mortality morbidity worldwide. Evidence suggests that CVDs share common risk factors pathophysiological mechanisms. Similar Mosaic Theory Hypertension proposed by Irvine Page in 1949, pathophysiology VTE is multifactorial, involving multiple interacting processes. The concept immunothrombosis, introduced Engelmann Massberg 2009, describes interplay between immune system thrombosis. Both thrombosis hemostasis core mechanisms, including platelet activation fibrin formation. Additionally, mediators—such as monocytes, neutrophil extracellular traps (NETs), lymphocytes, selectins, various molecular factors—play a critical role thrombus This review highlights inflammation key factor for pulmonary embolism (APE). Immunity central complex interactions coagulation cascade, platelets, endothelium, reactive oxygen species (ROS), genetic factors. Specifically, we examine roles cells, microRNAs (miRNAs) APE explore potential therapeutic targets. aims elucidate miRNAs future perspective.

Язык: Английский

Pulmonary embolism in children with mycoplasma pneumonia: can it be predicted?

European Journal of Clinical Microbiology & Infectious Diseases, Год журнала: 2024, Номер unknown

Опубликована: Дек. 17, 2024

Язык: Английский